Abstract: This invention provides novel indole, indazole, benzimidazole, benzotriazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating hyperproliferations of the prostate including pre-malignancies and benign prostatic hyperplasia, prostate cancer, advanced prostate cancer, castration resistant prostate cancer, other AR-expressing cancers, androgenic alopecia or other hyper androgenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels (through degradation) and/or activity (through inhibition) of any androgen receptor including androgen receptor-full length (AR-FL) including pathogenic and/or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

Abstract: A system and method to provide simulation augmented effects based event planning and management.

Abstract: An apparatus includes a body, a shaft, a stapling head assembly, and an anvil. The body includes a motor, a first user input feature, and a second user input feature. The first user input feature is operable to activate the motor. The shaft extends distally from the body. The stapling head assembly is positioned at a distal end of the shaft. The stapling head assembly includes an anvil coupling feature, at least one annular array of staples, and a staple driver. The second user input feature is operable to drive the anvil coupling feature longitudinally. The staple driver is operable to drive the at least one annular array of staples. The motor is operable to drive the staple driver. The anvil is configured to couple with the anvil coupling feature. The anvil is further configured to deform the staples driven by the staple driver.

Abstract: An expression system, including a host cell, a synthetic spider silk polypeptide-encoding nucleotide sequence, at least one synthetic tRNA molecule-encoding nucleotide sequence or a synthetic serine hydroxymethyl transferase (SHMT)-encoding nucleotide sequence.

Abstract: An expression system, including a host cell, a synthetic spider silk polypeptide-encoding nucleotide sequence, at least one synthetic tRNA molecule-encoding nucleotide sequence or a synthetic serine hydroxymethyl transferase (SHMT)-encoding nucleotide sequence.

Abstract: The present invention is a system and method that proactively identifies a student in need at an educational institution. The system allows for the educational institution to connect with the student, gather information, and provide assistance. Student needs that may be addressed are various and include academic, social, emotional, and spiritual. Because student needs are addressed in a timely and effective manner, the present invention may be used as a tool to increase retention rates at the educational institution.

Abstract: A pneumatically powered or combustion-powered fastener-driving tool for driving a fastener having a head into a gap between two brick faces affixed to a backing board in a siding panel. A workpiece-contacting element is adapted to contact the raised surfaces and is biased toward an extended position. A probe extending into the gap when the workpiece-contacting element contacts the brick faces and is moved into a retracted position is joined to such element so as to be conjointly movable therewith. A nosepiece, which guides the fastener as it is driven, is configured to extend into the gap, beyond the workpiece-contacting element when such element is moved into the retracted position.

Abstract: A switch lock is provided including a lock plug rotatable by a key between two or more positions within a lock barrel, and a switch is associated therewith such that one switch pole is selectively placed in one or more positions by the plug. A visual switch position indicator includes a second switch pole in the switch with a power source connected thereto, and an LED visible from the lock forward end has its leads connected to a terminal for selective connection to a power source in response to the position of the lock plug. The LED leads are flexible, disposed in a groove in the rear face of the lock bezel, and pass through a space between the lock barrel and the opening in the mounting plate. The switch wires are fixed to a connector and are protected by a shrink tube over the switch.

Abstract: A closure for opening and reclosing a package includes a base attachable to the top of the package over a scored area thereof, and a lever pivotally connected to the base at a rearward portion of the base so that by pivoting the lever, a portion of the lever penetrates the scored area of the package, and eventually, another portion of the lever seats over the open area of the package to provide a pouring spout. A removable cover is provided over the seating portion of the lever so that re-opening and resealing of the package occurs by removing the cover.

Abstract: A closure for opening and reclosing a package includes a base attachable to the top of the package over a scored area thereof, and a lever pivotally connected to the base at a rearward portion of the base so that by pivoting the lever, a portion of the lever penetrates the scored area of the package, and eventually, another portion of the lever seats over the open area of the package to provide a pouring spout. A removable cover is provided over the seating portion of the lever so that re-opening and resealing of the package occurs by removing the cover.

Abstract: An exhaust gas driven turbocharger is provided with a single pneumatic actuator which controls both a pivoting vane which varies the flow area or aspect ratio of the exhaust gas inlet passage to the turbine, and also controls the wastegate valve. A linkage mechanism including a preloaded spring and a bellcrank lever actuates levers controlling the wastegate valve and the pivoting vane.

Abstract: An ejection apparatus (19) for spinning and propelling objects (17) for ejection from a spacecraft (11) at a desired velocity and rotational speed. The apparatus includes a launch cradle (23) on which the space object (17) to be ejected rests. The cradle (23) is rotatably supported by a central hub (37) secured to upper end of pneumatic cylinder piston shaft (25). Release mechanisms (29) consisting of a retractable pin (75) and locking lug (72) is utilized to hold the cradle and object to be ejected. The release mechanism (29) has a fixed barrier member (76) which holds the retractable pin (75) in engagement with the locking lug (72) until release by upward movement of the launch cradle (23) beyond the barrier height.