Abstract: A system and method of multi-frame sampling for statistical analysis employs an estimator that may be generalize to two or more overlapping sampling frames. The estimator is accurate and requires less information and may be implemented more efficiently than previously known systems and methods. A generic computer system may be programmed to implement and employ the multi-frame sampling algorithms of the invention. Such algorithms may be employed to perform a statistical analysis on sample population data from multiple sample frames as stored in one or more databases accessible by the computer system.