Patents by Inventor Charles D. Stiles

Charles D. Stiles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA encoding human JE cytokine
    Patent number: 6787645
    Abstract: A novel human cytokine, JE factor, and processes for producing it are disclosed. JE may be used in pharmaceutical preparations for stimulating and/or enhancing immune responsiveness and in wound healing and related tissue repair. containing the factor.
    Type: Grant
    Filed: May 9, 1995
    Date of Patent: September 7, 2004
    Assignees: Dana-Farber Cancer Institute, Inc., Genetics Institute
    Inventors: Barrett J. Rollins, Charles D. Stiles, Gordon G. Wong
  • Trans-dominant suppressor genes for oligomeric proteins
    Patent number: 6475781
    Abstract: The invention features two methods for making eucaryotic trans-dominant suppressor genes encoding polypeptide translation products capable of suppressing the activity of a growth factor that requires an oligomeric state for function, suppressor genes made by the methods, protein products of the suppressor genes, and methods for using these genes and protein products.
    Type: Grant
    Filed: December 21, 1993
    Date of Patent: November 5, 2002
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Mark K. Mercola, Prescott L. Deininger, Charles D. Stiles
  • Activation-state-specific phosphoprotein immunodetection
    Patent number: 5599681
    Abstract: Activation-state-specific and protein-specific antiphosphoprotein antibodies and methods for their production are disclosed. Also disclosed are methods for evaluating the prognosis and therapeutic outcome for patients using the antiphosphoprotein antibodies and methods for characterizing the activation state of a reversibly phosphorylated protein, kits including the antibodies for use in characterizing the activation state of a protein, and methods for evaluating the agonist or antagonist activity of pharmaceutically useful compounds towards the conversion of a specific protein from its inactive to its active state.
    Type: Grant
    Filed: October 13, 1994
    Date of Patent: February 4, 1997
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Richard J. Epstein, Charles D. Stiles