Patents by Inventor Charles D. Surh

Charles D. Surh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-human interleukin-2 antibodies and uses thereof
    Patent number: 11117958
    Abstract: Provided is an antibody that binds to human interleukin-2 (hIL-2), and more particularly to an anti-hIL-2 antibody that binds specifically to a particular epitope of hIL-2, thereby inhibiting the binding of the hIL-2 to CD25. The anti-hIL-2 antibody of the subject matter binds specifically to a particular epitope of hIL-2, thereby inhibiting the binding of the hIL-2 to CD25, thereby minimizing expansion of Treg cells. In addition, it stimulates the CD8+ T cells and NK cells that exhibit anti-tumor activity. Thus, the anti-hIL-2 antibody of the present invention is useful as a new anticancer therapeutic agent.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: September 14, 2021
    Assignees: INSTITUTE FOR BASIC SCIENCE, POSTECH ACADEMY-INDUSTRY FOUNDATION
    Inventors: Charles D. Surh, Jun-Young Lee
  • ANTI-HUMAN INTERLEUKIN-2 ANTIBODIES AND USES THEREOF
    Publication number: 20200140538
    Abstract: Provided is an antibody that binds to human interleukin-2 (hIL-2), and more particularly to an anti-hIL-2 antibody that binds specifically to a particular epitope of hIL-2, thereby inhibiting the binding of the hIL-2 to CD25. The anti-hIL-2 antibody of the subject matter binds specifically to a particular epitope of hIL-2, thereby inhibiting the binding of the hIL-2 to CD25, thereby minimizing expansion of Treg cells. In addition, it stimulates the CD8+ T cells and NK cells that exhibit anti-tumor activity. Thus, the anti-hIL-2 antibody of the present invention is useful as a new anticancer therapeutic agent.
    Type: Application
    Filed: May 25, 2018
    Publication date: May 7, 2020
    Inventors: Charles D. SURH, Jun-Young LEE
  • Methods for Improving Immune Function and Methods for Prevention or Treatment of Disease in a Mammalian Subject
    Publication number: 20130142755
    Abstract: A method for increasing a biological activity of a cytokine or lymphokine and a method of treating a neoplastic disease, autoimmune disease, or infectious disease, and a method for expanding a hematopoietic cell population, is provided by administering an antibody capable of binding a cytokine or by administering a cytokine complexed with an antibody or by administering a cytokine complexed with a cytokine receptor to a mammalian subject in need thereof.
    Type: Application
    Filed: June 26, 2012
    Publication date: June 6, 2013
    Inventors: Onur Boyman, Charles D. Surh, Jonathan Sprent, Mark Rubinstein, Marek Kovar
  • Methods for Improving Immune Function and Methods for Prevention or Treatment of Disease in a Mammalian Subject
    Publication number: 20100310501
    Abstract: A method for increasing a biological activity of a cytokine or lymphokine and a method of treating a neoplastic disease, autoimmune disease, or infectious disease, and a method for expanding a hematopoietic cell population, is provided by administering an antibody capable of binding a cytokine or by administering a cytokine complexed with an antibody or by administering a cytokine complexed with a cytokine receptor to a mammalian subject in need thereof.
    Type: Application
    Filed: February 16, 2007
    Publication date: December 9, 2010
    Inventors: Onur Boyman, Charles D. Surh, Jonathan Sprent, Mark Rubinstein, Marek Kovar