Patents by Inventor Charles Danzin
Charles Danzin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5538978Abstract: This invention relates to novel purine nucleoside phosphorylase inhibitors, to the methods and intermediates for their preparation and to their use as immuno-suppressants, antilymphoma, antileukemic, antiviral and antiprotozoal agents.Type: GrantFiled: November 8, 1994Date of Patent: July 23, 1996Assignee: Merrell Pharmaceuticals Inc.Inventors: Serge Halazy, Charles Danzin
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Patent number: 5536732Abstract: This invention relates to novel N-derivatives of 1-deoxy nojirimycin, to the method for their preparation and to their use in the treatment of diabetes and the use against retro-viruses, particularly in the treatment of acquired immuno-deficiency syndrome (AIDS).Type: GrantFiled: July 14, 1993Date of Patent: July 16, 1996Assignee: Merrell Pharmaceuticals Inc.Inventors: Brigitte Lesur, Jean-Bernard Ducep, Charles Danzin
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Patent number: 5532397Abstract: This invention relates to substituted silyl alkylene amines, to the intermediates and processes useful for their preparation, to their pharmacological use as MAO-B inhibitors and to their end-use application in the treatment of Parkinson's Disease and senile dementia of Alzheimer's type.Type: GrantFiled: September 21, 1994Date of Patent: July 2, 1996Assignee: Merrell Pharmaceuticals Inc.Inventors: Daniel G. Schirlin, Jean-Noel Collard, Charles Danzin
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Patent number: 5529988Abstract: This invention relates to substituted silyl alkylene amines, to the intermediates and processes useful for their preparation, to their pharmacological use as MAO-B inhibitors and to their end-use application in the treatment of Parkinson's Disease and senile dementia of Alzheimer's type.Type: GrantFiled: January 27, 1995Date of Patent: June 25, 1996Assignee: Merrell Pharmaceuticals Inc.Inventors: Daniel G. Schirlin, Jean-Noel Collard, Charles Danzin
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Patent number: 5527803Abstract: This invention relates to novel purine nucleoside phosphorylase inhibitors, to the methods and intermediates for their preparation and to their use as immuno-suppressants, antilymphoma, antileukemic, antiviral and antiprotozoal agents.Type: GrantFiled: June 6, 1995Date of Patent: June 18, 1996Assignee: Merrell Pharmaceuticals Inc.Inventors: Serge Halazy, Charles Danzin
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Patent number: 5504078Abstract: This invention relates to novel polyglycosidyl derivatives of 1-deoxy-nojirimycin, to the processes for their preparation and to their end-use applications, particularly as to their use in the treatment of diabetes.Type: GrantFiled: December 7, 1992Date of Patent: April 2, 1996Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Jean-Bernard Ducep, Charles Danzin
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Patent number: 5494912Abstract: This invention relates to novel purine nucleoside phosphorylase inhibitors, to the methods and intermediates for their preparation and to their use as immunosuppressants, antilymphoma, antileukemic, antiviral and antiprotozoal agents.Type: GrantFiled: June 6, 1995Date of Patent: February 27, 1996Assignee: Merrell Pharmaceuticals Inc.Inventors: Serge Halazy, Charles Danzin
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Patent number: 5416076Abstract: The adenosine derivatives represented by the following formula: ##STR1## and the pharmaceutically acceptable salts thereof wherein R is H or C.sub.1 -C.sub.7 alkyl,Q is the moiety of the formula ##STR2## wherein V is H or --COOHX is H, F, Cl, Br, andZ is H, F, Cl, or Br.These compounds are inhibitors of S-adenosylmethione decarboxylase and are useful for treating parasitic infections.Type: GrantFiled: June 9, 1992Date of Patent: May 16, 1995Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Patrick Casara, Charles Danzin
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Patent number: 5384312Abstract: This invention relates to substituted silyl alkylene amines, to the intermediates and processes useful for their preparation, to their pharmacological use as MAO-B inhibitors and to their end-use application in the treatment of Parkinson's Disease and senile dementia of Alzheimer's type.Type: GrantFiled: April 30, 1992Date of Patent: January 24, 1995Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Daniel G. Schirlin, Jean-Noel Collard, Charles Danzin
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Patent number: 5252587Abstract: This invention relates to novel N-derivatives of 1-deoxy nojirimycin, to the method for their preparation and to their use in the treatment of diabetes and the use against retro-viruses, particularly in the treatment of acquired immuno-deficiency syndrome (AIDS).Type: GrantFiled: June 15, 1992Date of Patent: October 12, 1993Assignee: Merrell Dow Pharmaceuticals, Inc.Inventors: Brigitte Lesur, Jean-Bernard Ducep, Charles Danzin
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Patent number: 5157116Abstract: This invention relates to novel N-derivatives of 1-deoxy-nojirimycin, to the processes for their preparation and to their end-use applications, particularly as to their use in the treatment of diabetes.Type: GrantFiled: February 18, 1992Date of Patent: October 20, 1992Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Jean-Bernard Ducep, Charles Danzin
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Patent number: 5097023Abstract: This invention relates to novel N-glycosyl derivatives of 1,4-dideoxy-1,4-imino-D-arabinitol, to the chemical processes for their preparation, to their .alpha.-glucosidase inhibiting properties, and to their end-use application in the treatment of diabetes, obesity and those diseases associated with retroviruses, particularly the HIV virus reported to be the causative of the acquired immune deficiency syndrome (AIDS).Type: GrantFiled: September 17, 1990Date of Patent: March 17, 1992Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Jean-Bernard Ducep, Charles Danzin
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Patent number: 4988680Abstract: Halogenated 9-phosphonoalkyl derivatives of guanine and hypoxanthine are inhibitors of purine nucleoside phosphorylase and are useful as immuno suppressant and antiparasitic agents as well as against T cell leukemia and antiureicopoietic agents.Type: GrantFiled: April 14, 1989Date of Patent: January 29, 1991Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Serge J. Halazy, Charles Danzin
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Patent number: 4421768Abstract: Novel fluorinated diamino-heptene and-heptyne derivatives are inhibitors of ornithine decarboxylase enzyme involved in polyamine formation and have the following general Formula I: ##STR1## wherein: Y represents CH.sub.2 .dbd.CH-- or CH.tbd.C--; andp represents 1 or 2.Type: GrantFiled: August 11, 1982Date of Patent: December 20, 1983Assignee: Merrell Toraude et CompagnieInventors: Patrick Casara, Charles Danzin
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Patent number: 4374128Abstract: Novel compounds of the following general Formula I are useful pharmacological agents: ##STR1## wherein: Ado represents 5'-deoxyadenosin-5'-yl;R.sub.1 represents methyl, ethyl or, preferably hydrogen;R.sub.2 represents C.sub.1 -C.sub.8 alkylene;R.sub.4 represents C.sub.1 -C.sub.8 alkylene;R.sub.5 represents hydrogen, C.sub.1 -C.sub.6 alkyl or --R.sub.6 NHR.sub.7 ;R.sub.6 represents C.sub.1 -C.sub.4 alkylene; andR.sub.7 represents hydrogen or C.sub.1 -C.sub.6 alkyl;and pharmaceutically acceptable acid addition salts thereof.Type: GrantFiled: March 13, 1981Date of Patent: February 15, 1983Assignee: Merrell Toraude et CompagnieInventors: Philippe Bey, Michel Jung, Michael Kolb, Charles Danzin
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Patent number: 4323704Abstract: Novel compounds of the formula ##STR1## wherein A is methylene, ethylene or ethylidene; R.sub.1 is --C.tbd.CH or --CH.dbd.CH.sub.2 ; R.sub.2 is hydrogen or COR wherein R is hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, --NR.sub.4 R.sub.5 wherein each of R.sub.4 and R.sub.5 is hydrogen or a straight or branched lower alkyl group of from 1 to 4 carbon atoms or ##STR2## wherein R.sub.6 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; R.sub.a is hydrogen, ##STR3## alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched or ##STR4## wherein R.sub.7 is selected from hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl and p-hydroxybenzyl; and R.sub.b has the same meaning as defined for R.sub.a except R.sub.b is not ##STR5## and R.sub.a and R.sub.Type: GrantFiled: January 16, 1981Date of Patent: April 6, 1982Assignee: Merrell Toraude et CompagnieInventors: Brian W. Metcalf, Michel Jung, Charles Danzin
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Patent number: 4267374Abstract: Novel compounds of the formula ##STR1## wherein A is methylene, ethylene or ethylidene; R.sub.1 is --C.tbd.CH or --CH.dbd.CH.sub.2 ; R.sub.2 is hydrogen or COR wherein R is hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, --NR.sub.4 R.sub.5 wherein each of R.sub.4 and R.sub.5 is hydrogen or a straight or branched lower alkyl group of from 1 to 4 carbon atoms or ##STR2## wherein R.sub.6 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; R.sub.a is hydrogen, ##STR3## alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched or ##STR4## wherein R.sub.7 is selected from hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl and p-hydroxybenzyl; and R.sub.b has the same meaning as defined for R.sub.a except R.sub.b is not ##STR5## and R.sub.a and R.sub.Type: GrantFiled: June 25, 1979Date of Patent: May 12, 1981Assignee: Merrell Toraude et CompagnieInventors: Brian W. Metcalf, Michel Jung, Charles Danzin