Abstract: A lentiviral vector system for expressing a lentiviral particle is disclosed. The lentiviral vector system includes a therapeutic vector. The therapeutic vector comprises a phenylalanine hydroxylase (PAH) sequence for expressing at least one of PAH or a variant thereof, wherein the PAH sequence is truncated.

Abstract: The present disclosure relates generally to immunization and immunotherapy for the treatment or inhibition of HIV. In embodiments, a viral vectors are disclosed that comprise therapeutic cargo portions comprising a nucleotide sequence that encodes at least one soluble exogenous factor capable of inhibiting HIV infection, and a T cell-responsive promoter that regulates expression of the nucleotide sequence.

Abstract: An eye tracking system includes a pair of glasses including two frames, a projector coupled to the pair of glasses and operable to project a beam of light, and an eyepiece mounted in one of the two frames and optically coupled to the projector. The eyepiece is operable to direct at least a portion of the beam of light towards an eye of a user. The eye tracking system also includes one or more optical sensors coupled to at least one of the two frames of the pair of glasses and operable to detect a set of reflected signals off the eye of the user, and a processor coupled to the projector and the one or more optical sensors, wherein the processor is operable to determine an eye orientation based on the set of reflected signals.

Abstract: The present technology pertains to supporting contact interactions between avatars. For example, the present technology supports collisions between a collider and a receiver on avatars and effectuating a resulting effect. In another example, the present technology supports contact interactions that result in secondary motion behaviors from portions of an avatar. Portions of an avatar can be manipulated by forces from colliders that are exerted on the portions of the avatar configured with secondary motion. In addition to supporting interactions between avatars and portions of avatars, the present technology also solves other problems that are collateral to the supporting of contact interactions between avatars. One such problem is one of consent to engage in contact between avatars.

Abstract: A crop prediction system performs various machine learning operations to predict crop production and to identify a set of farming operations that, if performed, optimize crop production. The crop prediction system uses crop prediction models trained using various machine learning operations based on geographic and agronomic information. Responsive to receiving a request from a grower, the crop prediction system can access information representation of a portion of land corresponding to the request, such as the location of the land and corresponding weather conditions and soil composition. The crop prediction system applies one or more crop prediction models to the access information to predict a crop production and identify an optimized set of farming operations for the grower to perform.

Abstract: A method of assembling a bolt handle to a bolt assembly of a firearm includes inserting the bolt handle through a handle opening defined by a bolt body. A distal end of the bolt handle is inserted through the handle opening until the distal end extends past an outer perimeter of the bolt body. At least a portion of a bolt shroud is inserted through a first portion of an aperture defined by the bolt handle. A force is applied to the bolt shroud while the bolt handle is retracted within the handle opening of the bolt body so that the bolt shroud is positioned within a second portion of the aperture. The bolt shroud is held in connection with the bolt handle when the bolt shroud is positioned within the second portion of the aperture to secure the bolt handle to the bolt body.

Abstract: The present disclosure relates generally to immunization and immunotherapy for the treatment or prevention of HIV. In particular, the methods include purifying peripheral blood mononuclear cells (PBMC) from a source, stimulating the PBMC with at least one HIV-specific peptide, depleting at least one subset of cells from the PBMC, wherein the at least one subset of cells comprises any one or more of CD8+ T cells, CD4+ T cells, ?? cells, NK cells, B cells, T regulatory cells, and NKT cells, transducing the depleted PBMC with a viral delivery system encoding at least one genetic element, culturing the transduced PBMC for at least one day, and harvesting the cultured PBMC.

Abstract: A tubing retrievable safety valve assembly and related methods are disclosed herein. The assembly includes a primary flapper, a secondary flapper, a flow tube, and a protective sleeve. The flow tube is shiftable between a downhole position that holds the primary flapper in an open position and an uphole position that allows the primary flapper to move to a closed position. The protective sleeve, when positioned in an uphole position, holds the secondary flapper valve in an open position. The protective sleeve is shiftable to a downhole position to allow the secondary flapper to move to a closed position, for example, upon failure of the primary flapper.

Abstract: The present invention relates generally to immunization and immunotherapy for the treatment or prevention of HIV. In particular, the methods include in vivo and/or ex vivo enrichment of HIV-specific CD4+ T cells.

Abstract: In various embodiments, methods, systems, and computer program products are provided for estimating greenhouse gas emissions. In particular, methods, systems, and computer program products are presented for the task of quantifying emissions reduction from changes in stocks of soil organic carbon (SOC). The methods apply more generally to tasks that involve quantification of a total or average across a population of land (and/or possibly any space and any time) using measurements at a sample from that population. The sample may not be representative or unbiased. In some examples, estimating greenhouse gas emissions may apply to quantifying the total stock of SOC in land, the total nitrous oxide emissions in land and a time interval.

Abstract: Electronic devices that include a routing substrate with lower inductance path for a capacitor, and related fabrication methods. In exemplary aspects, to provide lower interconnect inductance for a capacitor coupled to a power distribution network in the routing substrate, an additional metal layer that provides an additional, second power plane is disposed in a dielectric layer between adjacent metal layers in adjacent metallization layers. The additional, second power plane is adjacent to a first power plane disposed in a first metal layer of one of the adjacent metallization layers. The disposing of the additional metal layer in the dielectric layer of the metallization layer reduces the thickness of the dielectric material between the first and second power planes coupled to the capacitor as part of the power distribution network. This reduced dielectric thickness between first and second power planes coupled to the capacitor reduces the interconnect inductance for the capacitor.

Abstract: The present invention relates generally to immunization and immunotherapy for the treatment or prevention of HIV. In particular, the methods include in vivo and/or ex vivo enrichment of HIV-specific CD4+ T cells.

Abstract: The present invention relates generally to immunization and immunotherapy for the treatment or prevention of HIV. In particular, the methods relate to in vivo and ex vivo enrichment of HIV-specific CD4 T cells. In certain embodiments, the disclosed compositions and methods can incorporate therapy in order to further enhance the HIV-specific CD4 T cells.

Abstract: A steering wheel control interface module that can automatically detect the type of vehicle it is installed in and automatically detect the type of aftermarket radio it is sending messages to. In addition, the interface module can retain certain user pre-selects and use those to properly set the state of an aftermarket radio.

Abstract: A ceiling fan includes a motor housing and a motor enclosed by the motor housing. A set of blades can extend from the motor housing and be operably coupled to the motor. The motor can include a rotor assembly and a stator assembly. The motor housing can include an upper housing and a lower housing.

Abstract: The present disclosure relates generally to modified NK cell compositions and methods of using the modified cell compositions in immunotherapy applications. In embodiments, the modified cell express a ? chain and a ? chain. In embodiments, the modified NK cell compositions can be used to treat various cancers.

Abstract: A semiconductor substrate includes a first semiconductor layer, a first dielectric layer coupled to the first semiconductor layer, and a second semiconductor layer coupled to the first dielectric layer. The second semiconductor layer includes a base portion substantially aligned with the first dielectric layer and a cantilever portion protruding from an end of the first dielectric layer. The cantilever portion includes a tapered surface tapering from a bottom surface of the second semiconductor layer toward a top surface of the second semiconductor layer.

Abstract: The present invention relates generally to immunization and immunotherapy for the treatment or prevention of HIV. In particular, the methods include in vivo and/or ex vivo enrichment of HIV-specific CD4+ T cells.

Abstract: An optical scanner is described and includes an optical beam assembly and a transducer. The optical beam assembly includes a pivoting portion having a cantilevered beam; a stationary portion; a first torsional flexure coupling a first side of the pivoting portion to the stationary portion; and a second torsional flexure coupling a second side of the pivoting portion to the stationary portion. The transducer includes a first magnetic element disposed on the pivoting portion and a second magnetic element disposed on the stationary portion. The first and second magnetic elements are configured to generate magnetic fields that interact to rotate the pivoting portion relative to the stationary portion about an axis defined by the first and second torsional flexures.