Abstract: A system comprises an imaging device for imaging within a body of a patient. The imaging device comprises a flexible elongate member and an imaging assembly disposed at a distal portion of the flexible elongate member. The imaging assembly comprises an array of imaging elements and a plurality of electronic components configured to perform an electrical function associated with imaging within the body of the patient using the array of imaging elements. Each of the plurality of electronic components is radiopaque such that the plurality of electronic components comprises a radiopaque pattern at the distal portion of the flexible elongate member. A method of imaging within a patient body comprises receiving a radiographic image representative of an ultrasound imaging device positioned within the patient body and determining an orientation of the ultrasound imaging device using a radiopaque pattern of a plurality of electronic components in the radiographic image.

Abstract: A method is provided by which payments for assets are recorded using blockchain transactions, and verified based on immutable logs associated with the transactions.

Abstract: A rotational intravascular ultrasound probe for insertion into a vasculature and a method of manufacturing the same. The rotational intravascular ultrasound probe comprises an elongate catheter having a flexible body and an elongate transducer shaft disposed within the flexible body. The transducer shaft comprises a proximal end portion, a distal end portion, a drive shaft extending from the proximal end portion to the distal end portion, an ultrasonic transducer disposed near the distal end portion for obtaining a circumferential image through rotation, and a transducer housing molded to the drive shaft and the ultrasonic transducer.

Abstract: A device for imaging within a body of a patient is provided. In one embodiment, the device includes a flexible elongate member that can be inserted into the body of the patient. The device also has an imaging assembly that is disposed at and extending a length of a distal portion of the flexible elongate member. The imaging assembly may include an array of imaging elements that may have an outward surface and an inward surface. The imaging assembly may further include an integrated circuit adjacent to the inward surface of the array of imaging elements. The device may further include a conductive plate adjacent to and extending at least a portion of a length of the imaging assembly. The conductive plate may receive heat generated by at least one of the array of imaging elements or the integrated circuit.

Abstract: The present invention relates to binding molecules (e.g. antibodies) for the treatment of cancer, and related antibody-drug conjugates.

Abstract: A rotational intravascular ultrasound probe for insertion into a vasculature and a method of manufacturing the same. The rotational intravascular ultrasound probe comprises an elongate catheter having a flexible body and an elongate transducer shaft disposed within the flexible body. The transducer shaft comprises a proximal end portion, a distal end portion, a drive shaft extending from the proximal end portion to the distal end portion, an ultrasonic transducer disposed near the distal end portion for obtaining a circumferential image through rotation, and a transducer housing molded to the drive shaft and the ultrasonic transducer.

Abstract: A device for imaging within a body of a patient is provided. In one embodiment, the device includes a flexible elongate member that can be inserted into the body of the patient. The device also has an imaging assembly that is disposed at and extending a length of a distal portion of the flexible elongate member. The imaging assembly may include an array (302) of imaging elements that may have an outward surface and an inward surface. The imaging assembly may further include an integrated circuit (304) adjacent to the inward surface of the array of imaging elements. The device may further include a conductive plate (375) adjacent to and extending at least a portion of a length of the imaging assembly. The conductive plate may receive heat generated by at least one of the array of imaging elements or the integrated circuit.

Abstract: An intraluminal sensing system is provided that includes an intraluminal device. The intraluminal device has a flexible elongate member configured to be positioned within a body lumen of a patient, and an ultrasound sensor at a distal portion of the flexible elongate member. The ultrasound sensor is configured to emit an ultrasound pulse in a longitudinal within the body lumen, and to receive Doppler-shifted echoes from the ultrasound pulse. A processor circuit in communication with the ultrasound sensor is configured to: compute a velocity spectrum of particles moving within the body lumen based on the Doppler-shifted echoes; identify features in the velocity spectrum indicative of a lateral position or angular alignment of the ultrasound sensor within the body lumen; and output, to a display in communication with the processor circuit, positioning guidance for the intraluminal device based on the identified features in the velocity spectrum.

Abstract: A rotational intravascular ultrasound probe for insertion into a vasculature and a method of manufacturing the same. The rotational intravascular ultrasound probe comprises an elongate catheter having a flexible body and an elongate transducer shaft disposed within the flexible body. The transducer shaft comprises a proximal end portion, a distal end portion, a drive shaft extending from the proximal end portion to the distal end portion, an ultrasonic transducer disposed near the distal end portion for obtaining a circumferential image through rotation, and a transducer housing molded to the drive shaft and the ultrasonic transducer.

Abstract: The present invention relates to binding molecules (e.g. antibodies) for the treatment of cancer, and related antibody-drug conjugates.

Abstract: An intraluminal medical imaging interface device includes an arm assembly comprising one or more longitudinal members and one or more joints coupled to the one or more longitudinal members, and a head assembly coupled to a distal portion of the arm assembly and comprising a proximal portion coupled to the distal portion of the arm assembly and a distal portion. The distal portion of the head assembly includes a mechanical coupling and an electrical coupling configured to separably connect to an intraluminal imaging catheter and to transmit electrical signals between a console and the intraluminal imaging catheter. The arm assembly is configured to couple to a surface to maintain the head assembly at a first position and an orientation with respect to a patient without continued support by an operator. Associated devices, systems, and methods are also provided.

Abstract: Routers and host machines can host desktops for two or more enterprises. A virtual local area network is established for each enterprise. Each virtual local area network is connected to a plurality of host machines for the enterprise, with each host machine supporting desktops for use by the enterprise. The desktops access computer resources on the enterprise network of the enterprise to which it is connected. Resources within a host machine are shared by having a virtual switch for each enterprise the host machine supports. The virtual switch for an enterprise is connected to the virtual local area network of the enterprise. Desktops in the host machine that are allocated to the enterprise are given network addresses that include the tag for that enterprise. Virtual desktops for different enterprises can be hosted on different partitions of the same host machine.

Abstract: A rotational intravascular ultrasound probe for insertion into a vasculature and a method of manufacturing the same. The rotational intravascular ultrasound probe comprises an elongate catheter having a flexible body and an elongate transducer shaft disposed within the flexible body. The transducer shaft comprises a proximal end portion, a distal end portion, a drive shaft extending from the proximal end portion to the distal end portion, an ultrasonic transducer disposed near the distal end portion for obtaining a circumferential image through rotation, and a transducer housing molded to the drive shaft and the ultrasonic transducer.

Abstract: According to a first aspect of the present invention, there is provided a method of slowing down a moving projectile, the projectile moving within an electromagnetic railgun, the method comprising: using an electromagnetic field generated by the railgun to slow down the projectile, wherein the projectile is a munitions projectile, and/or a carrier for catching the munitions projectile.

Abstract: According to a first aspect of the present invention, there is provided a method of slowing down a moving projectile, the projectile moving within an electromagnetic railgun, the method comprising: using an electromagnetic field generated by the railgun to slow down the projectile, wherein the projectile is a munitions projectile, and/or a carrier for catching the munitions projectile.

Abstract: A rotational intravascular ultrasound probe for insertion into a vasculature and a method of manufacturing the same. The rotational intravascular ultrasound probe comprises an elongate catheter having a flexible body and an elongate transducer shaft disposed within the flexible body. The transducer shaft comprises a proximal end portion, a distal end portion, a drive shaft extending from the proximal end portion to the distal end portion, an ultrasonic transducer disposed near the distal end portion for obtaining a circumferential image through rotation, and a transducer housing molded to the drive shaft and the ultrasonic transducer.

Abstract: A device for imaging within a body of a patient is provided. In one embodiment, the device includes a flexible elongate member that can be inserted into the body of the patient. The device also has an imaging assembly that is disposed at and extending a length of a distal portion of the flexible elongate member. The imaging assembly may include an array (302) of imaging elements that may have an outward surface and an inward surface. The imaging assembly may further include an integrated circuit (304) adjacent to the inward surface of the array of imaging elements. The device may further include a conductive plate (375) adjacent to and extending at least a portion of a length of the imaging assembly. The conductive plate may receive heat generated by at least one of the array of imaging elements or the integrated circuit.

Abstract: An intraluminal imaging device is provided. In one embodiment, the imaging device includes a flexible elongate member that may be inserted into a body lumen within a patient. The flexible elongate member may define a longitudinal axis. The imaging device also has an imaging assembly that is disposed at a distal portion of the flexible elongate member. The imaging assembly may have a plurality of ultrasound transducer elements disposed around the longitudinal axis. The imaging assembly further includes a first integrated circuit controller in communication with the plurality of ultrasound transducer elements. The first integrated circuit controller may be annularly shaped. In some embodiments, the imaging assembly may include a second integrated circuit controller in communication with the ultrasound transducer elements and the first integrated circuit controller. The second integrated circuit controller may be annularly shaped.

Abstract: A system comprises an imaging device for imaging within a body of a patient. The imaging device comprises a flexible elongate member and an imaging assembly disposed at a distal portion of the flexible elongate member. The imaging assembly comprises in an array of imaging elements and a plurality of electronic components configured to perform an electrical function associated with imaging within the body of the patient using the array of imaging elements. Each of the plurality of electronic components is radiopaque such that the plurality of electronic components comprises a radiopaque pattern at the distal portion of the flexible elongate member. A method of imaging within a patient body comprises receiving a radiographic image representative of an ultrasound imaging device positioned within the patient body and determining an orientation of the ultrasound imaging device using a radiopaque pattern of a plurality of electronic components in the radiographic image.

Abstract: Improved wiring arrangements for sensor catheters are provided to reduce wire-to-wire cross-talk wherein wires connecting the sensor of the sensor catheter to a processing unit are divided into a plurality of wire bundles contained within respective sheaths, with the wires in wire bundle twisted together reduce electromagnetic signal interference among the individual wires, or between wire bundles.