Patents by Inventor Charles E. Berkoff

Charles E. Berkoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2,3-Dichloro-4-hydroxy-benzoic acid and process for preparation thereof
    Patent number: 4092352
    Abstract: A Reimer-Tiemann reaction of 2,3-dichlorophenol with carbon tetrachloride gives 2,3-dichloro-4-hydroxy-benzoic acid, a novel intermediate, which is then reacted with thiophene in the presence of phosphorus pentoxide or polyphosphoric acid to give 2,3-dichloro-4-(2-thienoyl)-phenol. This compound is then converted to the diuretic, ticrynafen, by known prior art reactions.
    Type: Grant
    Filed: October 4, 1976
    Date of Patent: May 30, 1978
    Assignee: SmithKline Corporation
    Inventors: Charles E. Berkoff, Robert Lee Webb
  • Process using alkali fusion for decyanation of tert.-nitriles
    Patent number: 4079061
    Abstract: An improvement in the decyanation of tertiary nitriles comprises the alkali fusion of the nitriles. Exemplary are the preparation of chlorpheniramine and brompheniramine by heating the respective nitriles in liquid sodium or potassium hydroxide at from 100.degree.-200.degree..
    Type: Grant
    Filed: June 21, 1976
    Date of Patent: March 14, 1978
    Assignee: SmithKline Corporation
    Inventors: Charles E. Berkoff, Donald E. Rivard
  • Heterocyclic homoprostanoidal derivatives
    Patent number: 3978225
    Abstract: Heterocyclic homoprostanoidal derivatives are prepared. These compounds have valuable antiprostaglandin activity specifically inhibiting prostaglandin synthesis and antagonizing diarrhea induced by prostaglandin E.sub.2 (PGE.sub.2).
    Type: Grant
    Filed: May 13, 1975
    Date of Patent: August 31, 1976
    Assignee: SmithKline Corporation
    Inventors: Allan D. Bender, Charles E. Berkoff, William G. Groves
  • Substituted cyano,trifluoromethylphenyl linear triazenes
    Patent number: 3976633
    Abstract: The compounds of this invention are substituted cyano,trifluoromethylphenyl linear triazenes having pharmacological activity. In particular, these compounds have anorectic and anti-obesity activity. A preferred compound is 1,3-bis(2-cyano-5-trifluoromethylphenyl)triazene.
    Type: Grant
    Filed: June 3, 1974
    Date of Patent: August 24, 1976
    Assignee: SmithKline Corporation
    Inventors: Charles E. Berkoff, David T. Hill, Bernard Loev
  • Anti-arthritic 1H-pyrimido-(5,4,3-kl)phenothiazine-1,3(2H)-diones and 1-thiones
    Patent number: 3962438
    Abstract: 1H-Pyrimido[5,4,3-kl]phenothiazine-1,3(2H)-diones are prepared from the corresponding 1-thione-3-one compounds by methylation followed by acid hydrolysis. The 1,3-dione products and 1-thione-3-one intermediates are useful as anti-arthritic agents.
    Type: Grant
    Filed: January 7, 1975
    Date of Patent: June 8, 1976
    Assignee: SmithKline Corporation
    Inventors: Charles E. Berkoff, Blaine M. Sutton, Joseph Weinstock