Abstract: The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A dispensing device includes a hollow body coupled to a pump mechanism having a dip tube, and to a follower piston. A well provided in the piston is generally larger in diameter than the dip tube to allow fluid in the chamber to flow down into the well as the dip tube enters the well to facilitate fluid removal after a significant portion of the fluid has been removed.

Abstract: A dispensing device includes a hollow body coupled to a pump mechanism having a dip tube, and to a follower piston. A well provided in the piston is generally larger in diameter than the dip tube to allow fluid in the chamber to flow down into the well as the dip tube enters the well to facilitate fluid removal after a significant portion of the fluid has been removed.

Abstract: The present invention provides methods for reducing pain associated with chronic anal fissures with reduced side effects, comprising: contacting an anal area with a composition comprising an effective amount of nitroglycerin, thereby relieving pain associated with anal fissures. It also provides a extremely stable pharmaceutical composition comprising nitroglycerin, propylene glycol, and a non-ionic surfactant, as well as kits.

Abstract: An entrapped gas measuring apparatus includes a reservoir housing with a reservoir which is adapted to receive a material sample and to expand according to an expansion of the material sample when a negative pressure is applied externally to the reservoir. A parameter indicating the change in volume of the reservoir during the expansion, such as the actual change of volume of the reservoir or a change in position of a moveable wall which at least in part defines the reservoir, is detected by a detector. A processor coupled to the detector is used to determine the amount of entrapped gas based upon the detected parameter. The amount of entrapped gas determined by the processor may be the percent volume of the entrapped gas in relation to the overall volume of the sample, or may be the actual volume of the entrapped gas in the sample.

Abstract: This invention relates to coating formulations for coating sustained-release drug implants. The coating formulations are capable of formulations are capable of forming a porous film coat over a biologically active agent to provide a release of the active agent at a constant rate over a prolonged period of time. The pore forming agent is used in the formulation of the invention in the amount effective to regulate the release of a biologically active compound at a desired rate. Preferably, the effective amount of the pore forming agent provides long term delivery of the active agent. The invention also provides an improved implant for the sustained administration of a biologically active compound suitable for subcutaneous implantation. The invention also relates to methods for making and using the formulation and the implant of the invention.

Abstract: A product display including a base unit having a header portion and a strip portion, the strip portion having a plurality of sets of apertures along its length and at least one product hanger having a pair of ends which are removably positionable in the apertures to secure the product hanger to the strip portion, the product hanger including a support member adapted to support products to be displayed.

Abstract: A measuring instrument for measuring the distance from a hole, drilled at the intersection of a rib and a stringer, to the adjacent flange of the rib includes two arms projecting laterally out from the side of the instrument and forward to engage the flange. The arms are geared together at their inner ends within the body of the instrument to insure that the angles of both arms relative to the longitudinal axis of the body are equal to each other so that the longitudinal axis of the instrument in use remains perpendicular to the face of the flange. A spring loaded conical hole-centering probe protruding from the bottom face of the instrument fits into and centers itself in the hole and establishes a reference from which the flange is measured. A stylus, slidably mounted in the instrument and protruding from the front end thereof, contacts the face of the flange.

Abstract: The presence of persons in a space is sensed with the aid of ultrasonic pulses which are sent out into the space when echoes of such ultrasonic pulses are received. Echoes attributable to the floor or to parts of a door in the space are timed out, and a remainder of such echoes is employed for sensing persons in the space. For example, sliding or revolving doors may be controlled and operated with the aid of such ultrasonic echoes, and limited access to secured areas may be provided thereby.

Abstract: Disclosed audio signal recording methods and apparatus operate with a telephone set having a housing and a handset connected to a first modular jack in the housing via a handset cord having at an end thereof a first modular plug fitting into the first modular jack. For audio signal tapping purposes, there is provided a second modular plug fitting into the first modular jack, a second modular jack for receiving the first modular plug, and an electrical interconnection of the second modular jack with the second modular plug. The second modular plug is inserted into the first modular jack and the first modular plug into the second modular jack. Audio signals are tapped from the electrical interconnection of the second modular jack with the second modular plug and are recorded.

Abstract: An improved method for testing the integrity of containers and closures for same is disclosed which is simple, easy to perform, and possesses a high degree of sensitivity. The method comprises immersing a container (whose walls are substantially transparent and in which a substantially transparent liquid is stored) into a solution of a dye under conditions which will favor the passage of the dye through any leaks present in the container or closure and into the liquid. The container is then placed in the path of a laser beam emitting a wavelength which approximates the fluorescent excitation frequency of the dye. If the color of the beam transmitted through the liquid is that which is characteristic for the fluorescing dye, a leak in the system is indicated.