Patents by Inventor Charles E. McQueen

Charles E. McQueen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • “Burst-free” sustained release poly-(lactide/glycolide) microspheres
    Patent number: 7033608
    Abstract: Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1–100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer as a blend of uncapped (free carboxyl end group) and end-capped forms ranging in ratios from 100/0 to 1/99.
    Type: Grant
    Filed: June 22, 1999
    Date of Patent: April 25, 2006
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Ramasubbu Jevanthi, John E. Van Hamont, Phil Friden, Robert H. Reid, F. Donald Roberts, Charles E. McQueen, Jean A. Setterstrom
  • Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix
    Patent number: 6902743
    Abstract: Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer having a molar composition of lactide/glycolide from 90/10 to 40/60, which may contain a pharmaceutically-acceptable adjuvant, as a blend of uncapped free carboxyl end group and end-capped forms ranging to ratios from 100/0 to 1/99.
    Type: Grant
    Filed: April 6, 1998
    Date of Patent: June 7, 2005
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Jean A. Setterstrom, Thomas R. Tice, Elliot Jacob, Robert H. Reid, John van Hamont, Edgar C. Boedecker, Ramassubbu Jeyanthi, Phil Friden, F. Donald Roberts, Charles E. McQueen, Apurba Bhattacharjee, Alan Cross, Jerald Sadoff, Wendell Zollinger
  • Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
    Patent number: 6844010
    Abstract: Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer, which may contain a pharmaceutically-acceptable adjuvant, as a blend of upcapped free carboxyl end group, and end-capped forms ranging in ratios from 100/0 to 1/99.
    Type: Grant
    Filed: July 18, 2000
    Date of Patent: January 18, 2005
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Jean A. Setterstrom, John E. Van Hamont, Robert H. Reid, Elliot Jacob, Ramasubbu Jeyanthi, Edgar C. Boedeker, Charles E. McQueen, Daniel L. Jarboe, Frederick Cassels, William Brown, Curt Thies, Thomas R. Tice, F. Donald Roberts, Phil Friden
  • Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
    Patent number: 6309669
    Abstract: Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer, which may contain a pharmaceutically-acceptable adjuvant, as a blend of upcapped free carboxyl end group and end-capped forms ranging in ratios from 100/0 to 1/99.
    Type: Grant
    Filed: January 27, 1997
    Date of Patent: October 30, 2001
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Jean A. Setterstrom, John E. Van Hamont, Robert H. Reid, Elliot Jacob, Ramasubbu Jeyanthi, Edgar C. Boedeker, Charles E. McQueen, Daniel L. Jarboe, Frederick Cassels, William Brown, Curt Thies, Thomas R. Tice, F. Donald Roberts, Phil Friden
  • Extraction process for producing PLGA microspheres
    Patent number: 5705197
    Abstract: A hybrid evaporation-extraction process for preparing microspheres of a p(DL-lactide-to-glycolide) biodegradable polymer, comprising:a. preparing a lyophilized biologically active material-sucrose matrix; adding acetonitrile solvent to biologically active material-sucrose matrix to form a solution;b. preparing a solution of a biodegradable poly (DL-lactide-co-glycolide) polymer by adding acetonitrile solvent to the polymer;c. adding the biodegradable poly (DL-lactide-co-glycolide) polymer acetonitrile solution to the biologically active material-sucrose acetonitrile solution;d. adding with stirring an oil containing lecithin to the poly (DL-lactide-co-glycolide) polymer-sucrose-biologically active material solution to evaporate acetonitrile and form an emulsion containing microspheres of poly (DL-lactide-co-glycolide) biodegradable polymers;e. adding the emulsion from step d. into a solvent selected from heptane, hexane, pentane or isopropanol; andf.
    Type: Grant
    Filed: August 16, 1996
    Date of Patent: January 6, 1998
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: John Van Hamont, Curt Thies, Robert H. Reid, Charles E. McQueen, Jean A. Setterstrom