Patents by Inventor Charles E. Murry

Charles E. Murry has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12208133
    Abstract: Provided herein are isolated nucleic acids that encode a stable form of Rrm2 for the use of increasing the intracellular Rrm2 protein levels and cytosolic 2-deoxy-ATP (dATP) levels. Further provided herein are methods for treating a cardiac disease or disorder, e.g., myocardial infarction or myocardial ischemia, by administering the isolated nucleic acids, a polypeptide encoded by the isolated nucleic acids, or composition comprising the isolated nucleic acids to a subject in need thereof.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: January 28, 2025
    Assignee: UNIVERSITY OF WASHINGTON
    Inventors: Michael Regnier, Charles E. Murry, Xuan Guan
  • Patent number: 12060579
    Abstract: Provided herein are methods that enable the polarization of hPSC mesoderm such that closely related yet distinct cardiovascular populations can be generated efficiently without the need of post-facto enrichment.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: August 13, 2024
    Assignee: UNIVERSITY OF WASHINGTON
    Inventors: Charles E. Murry, Lil Pabon, Nathan Palpant
  • Publication number: 20230293581
    Abstract: Disclosed herein are hypoimmunogenic cells for administering to a sensitized patient. In some instances, the patient is sensitized from a previous pregnancy or a previous transplant. In some embodiments, the cells exogenously express CD47 proteins and exhibit reduced expression of MHC class I proteins, MHC class II proteins, or both.
    Type: Application
    Filed: August 12, 2021
    Publication date: September 21, 2023
    Inventors: Sonja Schrepfer, Steve Harr, Charles E. Murry
  • Patent number: 11752176
    Abstract: Provided herein are methods and compositions comprising cardiomyocytes and epicardial cells for the treatment of cardiac disease.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: September 12, 2023
    Assignees: University of Washington, Cambridge Enterprise Limited
    Inventors: Charles E. Murry, Sanjay Sinha, Johannes Bargehr
  • Patent number: 11331027
    Abstract: Devices and techniques for magnetic detection of myocardial forces are generally described. In some examples, cardiac tissue may be cultured such that the cardiac tissue adheres to a first post and a second post. In further examples, a magnetometer may detect a change in a magnetic field resulting from a deflection of the first post in a first direction from a first position to a second position. In some other examples a signal corresponding to the change in the magnetic field may be generated. In still other examples, frequencies of the signal outside of a first frequency range may be excluded to produce a filtered signal. In various examples, the first frequency range may include frequencies associated with beating of cardiac tissue. In still further examples, a force exerted by the cardiac tissue may be determined based at least in part on the filtered signal.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: May 17, 2022
    Assignee: University of Washington
    Inventors: Nathan J. Sniadecki, Shiv Bhandari, Kevin S. Bielawski, Andrea B. Leonard, Charles E. Murry
  • Publication number: 20220049226
    Abstract: Disclosed herein are hypoimmunogenic cells for administering to a sensitized patient. In some instances, the patient is sensitized from a previous pregnancy or a previous transplant. In some embodiments, the cells exogenously express CD47 proteins and exhibit reduced expression of MHC class I proteins, MHC class II proteins, or both.
    Type: Application
    Filed: August 12, 2021
    Publication date: February 17, 2022
    Inventors: Sonja Schrepfer, Steve Harr, Charles E. Murry
  • Publication number: 20200231933
    Abstract: Provided herein are methods that enable the polarization of hPSC mesoderm such that closely related yet distinct cardiovascular populations can be generated efficiently without the need of post-facto enrichment.
    Type: Application
    Filed: February 26, 2020
    Publication date: July 23, 2020
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Charles E. Murry, Lil Pabon, Nathan Palpant
  • Patent number: 10612002
    Abstract: Provided herein are methods that enable the polarization of hPSC mesoderm such that closely related yet distinct cardiovascular populations can be generated efficiently without the need of post-facto enrichment.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: April 7, 2020
    Assignee: UNIVERSITY OF WASHINGTON
    Inventors: Charles E. Murry, Lil Pabon, Nathan Palpant
  • Publication number: 20190029549
    Abstract: Devices and techniques for magnetic detection of myocardial forces are generally described. In some examples, cardiac tissue may be cultured such that the cardiac tissue adheres to a first post and a second post. In further examples, a magnetometer may detect a change in a magnetic field resulting from a deflection of the first post in a first direction from a first position to a second position. In some other examples a signal corresponding to the change in the magnetic field may be generated. In still other examples, frequencies of the signal outside of a first frequency range may be excluded to produce a filtered signal. In various examples, the first frequency range may include frequencies associated with beating of cardiac tissue. In still further examples, a force exerted by the cardiac tissue may be determined based at least in part on the filtered signal.
    Type: Application
    Filed: March 10, 2017
    Publication date: January 31, 2019
    Inventors: Nathan J. Sniadecki, Shiv Bhandari, Kevin S. Bielawski, Andrea B. Leonard, Charles E. Murry
  • Publication number: 20170240861
    Abstract: Provided herein are methods that enable the polarization of hPSC mesoderm such that closely related yet distinct cardiovascular populations can be generated efficiently without the need of post-facto enrichment.
    Type: Application
    Filed: February 21, 2017
    Publication date: August 24, 2017
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Charles E. Murry, Lil Pabon, Nathan Palpant
  • Patent number: 7875451
    Abstract: The survival of cells during transplantation is enhanced. Cells to be transplanted are administered in a formulation that provides two ore more survival enhancing factors. Optionally, prior to administration, the cells are cultured in the presence of factors that enhance survival, and may be heat shocked prior to transplantation.
    Type: Grant
    Filed: January 19, 2006
    Date of Patent: January 25, 2011
    Assignee: The University of Washington
    Inventors: Charles E. Murry, Michael Alan Laflamme