Abstract: A method and system for point-of-dispensing, point-of-sale, or retail pharmacy management of an anticoagulation agent therapy for a subject, includes reviewing an anticoagulation regimen and obtaining data for a subject relating to anticoagulation therapy, determining an International Normalized Ratio (INR) level for the subject, determining any potential interaction of the anticoagulation agent with one or more non-anticoagulation agents that the subject intends to take or is taking, evaluating in real time any need to adjust the anticoagulation regimen, and adjusting in real time, if needed, the anticoagulation regimen based on one or both INR level and any interaction determinations, to maintain the subject's INR level within a desired range.