Patents by Inventor Charles E. Ribak

Charles E. Ribak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • In vitro assay method for the study of brain aging
    Patent number: 6447988
    Abstract: Cultured brain slices are treated with a free radical generator, in the presence of a lysosomal enzyme inhibitor (specifically an inhibitor of two cathepsins). The treated brain slices rapidly develop autofluorescent lipofuscin granules—a universal feature of brain aging. Other correlates of the aged brain are also induced by this treatment, thereby providing an in vitro model for (1) the study of brain aging; (2) assessment of anti-brain aging drugs; and (3) therapeutics directed at the clinical condition referred to as neuronal ceroidlipofuscinosis.
    Type: Grant
    Filed: January 22, 1997
    Date of Patent: September 10, 2002
    Assignee: The Regents of the University of California
    Inventors: Gary S. Lynch, Eric Bednarski, Charles E. Ribak, Christine M. Gall
  • AN IN VITRO ASSAY METHOD FOR THE STUDY OF BRAIN AGING
    Publication number: 20010007854
    Abstract: Cultured brain slices are treated with a free radical generator, in the presence of a lysosomal enzyme inhibitor (specifically an inhibitor of two cathepsins). The treated brain slices rapidly develop autofluorescent lipofuscin granules-a universal feature of brain aging. Other correlates of the aged brain are also induced by this treatment, thereby providing an in vitro model for (1) the study of brain aging; (2) assessment of anti-brain aging drugs; and (3) therapeutics directed at the clinical condition referred to as neuronal ceroid-lipofuscinosis.
    Type: Application
    Filed: January 22, 1997
    Publication date: July 12, 2001
    Inventors: GARY S. LYNCH, ERIC BEDNARSKI, CHARLES E. RIBAK, CHRISTINE M. GALL