Abstract: Efficient distributed indexing of clumpy data is disclosed. For example, a plurality of data stores store a plurality of data objects, where a plurality of data references to each of the plurality of data objects is recorded on a distributed index and an index manager executes a processor to temporarily partition a namespace of the plurality of data references into a plurality of temporary partitions. A respective count of data references in each temporary partition is computed. A trend line approximating a distribution of data references is calculated based on the respective counts. A cumulative representation of the distribution of the respective counts is calculated based on the trend line. The namespace is repartitioned based on the cumulative representation resulting in a repartitioned namespace, where the distributed index is divided into index segments based on the repartitioned namespace.

Abstract: Efficient distributed indexing of clumpy data is disclosed. For example, a plurality of data stores store a plurality of data objects, where a plurality of data references to each of the plurality of data objects is recorded on a distributed index and an index manager executes a processor to temporarily partition a namespace of the plurality of data references into a plurality of temporary partitions. A respective count of data references in each temporary partition is computed. A trend line approximating a distribution of data references is calculated based on the respective counts. A cumulative representation of the distribution of the respective counts is calculated based on the trend line. The namespace is repartitioned based on the cumulative representation resulting in a repartitioned namespace, where the distributed index is divided into index segments based on the repartitioned namespace.

Abstract: The present invention relates to methods of screening for modulators of Hedgehog peptide autoprocessing with methods that are useful in both in vivo and high-throughput in vitro systems. The present invention also relates to reagents identified by the methods of the present invention for use in the modulation of Hh autoprocessing, especially as they relate to the treatment of illnesses and diseases that are caused, at least in part, by the misregulation of Hh autoprocessing.

Abstract: Methods and compositions for inhibiting FGF signaling are described. Methods of the invention include contacting an FGF-responsive cell with exogenous heparan sulfate 6-O endosulfatase (Sulf1) in an amount effective to modify endogenous heparan sulfate, thereby inhibiting FGF signaling. Methods of the invention also include contacting an FGF-responsive cell with an exogenous Sulf1-modified compound, the exogenous Sulf1-modified compound being characterized by the ability to reduce binding of FGF2 or FGF4 to FGFR1. Compositions comprising exogenous Sulf1-modified compounds are also provided for use in conjunction with methods of the present invention.