Patents by Inventor Charles Emery
Charles Emery has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10066011Abstract: Antibodies directed to the antigen Ang-2 and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen Ang-2. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.Type: GrantFiled: September 15, 2014Date of Patent: September 4, 2018Assignee: MedImmune LimitedInventors: Larry L. Green, Qing Zhou, Bruce A. Keyt, Xiao-Dong Yang, Stephen Charles Emery, David Charles Blakey
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Publication number: 20160251421Abstract: The invention relates to agents which possess anti-antigenic activity and are accordingly useful in methods of treatment of disease states associated with angiogenesis in the animal or human body. More specifically the invention concerns a combination of an antagonist of the biological activity of Angiopoietin-2 and an antagonist of the biological activity of VEGF-A, and/or KDR, and/or Flt1, and uses of such antagonists.Type: ApplicationFiled: February 29, 2016Publication date: September 1, 2016Inventors: Jeffrey Lester Brown, Stephen Charles Emery, David Charles Blakey
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Patent number: 9220488Abstract: A targeting catheter is used to locate an arteriotomy, such as is formed during a femoral artery catheterization procedure. The targeting catheter includes one or more targeting aids, such as an inflatable balloon or sensor (e.g., Doppler or temperature sensor), to locate the arteriotomy. The targeting aid may be positioned at the arteriotomy. An ultrasonic beacon on the catheter may then be located relative to a therapeutic ultrasonic applicator (e.g., by using acoustic time-of-flight) so that the focus of ultrasonic energy from the applicator can be aligned with the arteriotomy.Type: GrantFiled: September 14, 2012Date of Patent: December 29, 2015Assignee: Kona Medical, Inc.Inventors: Charles Emery, Larry Augustine, Robyn Lahman, David M. Perozek, Jimin Zhang
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Publication number: 20150196783Abstract: Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device that employs high intensity focused ultrasound. The high intensity focused ultrasound may be used for application of energy to modulate neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. The ultrasound transducer for delivering the energy may be located remotely from the desired treatment area. In particular embodiments, an ultrasound transducer may apply energy at one or more focal zones or focal points that target renal nerves.Type: ApplicationFiled: December 17, 2014Publication date: July 16, 2015Inventors: Charles Emery, Mark Gelfand, Howard Levin, Denise Zarins
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Publication number: 20150125455Abstract: Antibodies directed to the antigen Ang-2 and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen Ang-2. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.Type: ApplicationFiled: September 15, 2014Publication date: May 7, 2015Inventors: Larry L. GREEN, Qing ZHOU, Bruce A. KEYT, Xiao-Dong YANG, Stephen Charles EMERY, David Charles BLAKEY
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Publication number: 20150080926Abstract: Medical devices, systems, and methods for achieving renal neuromodulation by extracorporeal application of energy are disclosed herein. One aspect of the present disclosure is directed to apparatuses, systems, and methods that incorporate a device that employs high-intensity focused ultrasound. The high-intensity focused ultrasound may be used for application of energy to modulate neural fibers that contribute to renal function, or to vascular structures that feed or perfuse the neural fibers. The ultrasound transducer for delivering the energy may be located remotely from the desired treatment area and/or may be located outside the patient's body. In particular embodiments, an ultrasound transducer may be coupled to a targeting system that may be extracorporeal or intravascular.Type: ApplicationFiled: February 25, 2013Publication date: March 19, 2015Applicant: Medtronic Ardian Luxembourg S.a.r.l.Inventor: Charles Emery
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Patent number: 8834880Abstract: Antibodies directed to the antigen Ang-2 and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen Ang-2. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.Type: GrantFiled: November 30, 2012Date of Patent: September 16, 2014Assignee: MedImmune LimitedInventors: Larry L. Green, Qing Zhou, Bruce A. Keyt, Xiao-Dong Yang, Stephen Charles Emery, David Charles Blakey
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Publication number: 20140023654Abstract: The invention relates to agents which possess anti-angiogenic activity and are accordingly useful in methods of treatment of disease states associated with angiogenesis in the animal or human body. More specifically the invention concerns a combination of an antagonist of the biological activity of Angiopoietin-2 and an antagonist of the biological activity of VEGF-A, and/or KDR, and/or Flt1, and uses of such antagonists.Type: ApplicationFiled: July 29, 2013Publication date: January 23, 2014Applicant: Medimmune LimitedInventors: Jeffrey Lester BROWN, Stephen Charles Emery, David Charles Blakey
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Patent number: 8372009Abstract: A targeting catheter is used to locate an arteriotomy, such as is formed during a femoral artery catheterization procedure. The targeting catheter includes one or more targeting aids, such as an inflatable balloon or sensor (e.g., Doppler or temperature sensor), to locate the arteriotomy. The targeting aid may be positioned at the arteriotomy. An ultrasonic beacon on the catheter may then be located relative to a therapeutic ultrasonic applicator (e.g., by using acoustic time-of-flight) so that the focus of ultrasonic energy from the applicator can be aligned with the arteriotomy.Type: GrantFiled: September 26, 2011Date of Patent: February 12, 2013Assignee: Kona Medical, Inc.Inventors: Charles Emery, Larry Augustine, Robyn Lahman, David M Perozek, Jimin Zhang
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Publication number: 20130012839Abstract: A targeting catheter is used to locate an arteriotomy, such as is formed during a femoral artery catheterization procedure. The targeting catheter includes one or more targeting aids, such as an inflatable balloon or sensor (e.g., Doppler or temperature sensor), to locate the arteriotomy. The targeting aid may be positioned at the arteriotomy. An ultrasonic beacon on the catheter may then be located relative to a therapeutic ultrasonic applicator (e.g., by using acoustic time-of-flight) so that the focus of ultrasonic energy from the applicator can be aligned with the arteriotomy.Type: ApplicationFiled: September 14, 2012Publication date: January 10, 2013Applicant: Kona Medical, Inc.Inventors: Charles Emery, Larry Augustine, Robyn Lahman, David M. Perozek, Jimin Zhang
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Publication number: 20120288497Abstract: The invention relates to agents which possess anti-angiogenic activity and are accordingly useful in methods of treatment of disease states associated with angiogenesis in the animal or human body. More specifically the invention concerns a combination of an antagonist of the biological activity of Angiopoietin-2 and an antagonist of the biological activity of VEGF-A, and/or KDR, and/or Flt1, and uses of such antagonists.Type: ApplicationFiled: May 16, 2012Publication date: November 15, 2012Applicant: MedImmune LimitedInventors: DAVID CHARLES BLAKEY, JEFFREY LESTER BROWN, STEPHEN CHARLES EMERY
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Publication number: 20120109023Abstract: Systems and methods for maintaining the alignment of a therapeutic ultrasound applicator to a target site are described. Overlapping ultrasound signals are sent to a target tissue site and the echo detected. An algorithm is described for detecting tissue movement relative to the applicator based on comparison of the echo with a previously stored echo.Type: ApplicationFiled: January 5, 2012Publication date: May 3, 2012Applicant: Kona Medical, Inc.Inventors: Charles Emery, Larry Augustine, Robyn Lahman, David M. Perozek, Jimin Zhang
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Publication number: 20120108797Abstract: Targeted binding agents directed to the antigen uPAR and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen uPAR. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementary determine regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.Type: ApplicationFiled: July 28, 2011Publication date: May 3, 2012Applicant: MedImmune LimitedInventors: Paul Elvin, Stephen Charles Emery, Qing Zhou
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Patent number: 8167805Abstract: Systems and methods for maintaining the alignment of a therapeutic ultrasound applicator to a target site are described. Overlapping ultrasound signals are sent to a target tissue site and the echo detected. An algorithm is described for detecting tissue movement relative to the applicator based on comparison of the echo with a previously stored echo.Type: GrantFiled: October 19, 2006Date of Patent: May 1, 2012Assignee: Kona Medical, Inc.Inventors: Charles Emery, Larry Augustine, Robyn Lahman, David M. Perozek, Jimin Zhang
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Publication number: 20120059259Abstract: A targeting catheter is used to locate an arteriotomy, such as is formed during a femoral artery catheterization procedure. The targeting catheter includes one or more targeting aids, such as an inflatable balloon or sensor (e.g., Doppler or temperature sensor), to locate the arteriotomy. The targeting aid may be positioned at the arteriotomy. An ultrasonic beacon on the catheter may then be located relative to a therapeutic ultrasonic applicator (e.g., by using acoustic time-of-flight) so that the focus of ultrasonic energy from the applicator can be aligned with the arteriotomy.Type: ApplicationFiled: September 26, 2011Publication date: March 8, 2012Applicant: Kona Medical, Inc.Inventors: Charles Emery, Larry Augustine, Robyn Lahman, David M. Perozek, Jimin Zhang
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Publication number: 20120052073Abstract: Antibodies directed to the antigen Ang-2 and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen Ang-2. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.Type: ApplicationFiled: June 27, 2011Publication date: March 1, 2012Applicant: Medlmmune LimitedInventors: Larry L. Green, Qing Zhou, Bruce A. Keyt, Xiao-Dong Yang, Stephen Charles Emery, David Charles Blakey
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Patent number: 8026344Abstract: Targeted binding agents directed to the antigen uPAR and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen uPAR. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.Type: GrantFiled: April 9, 2007Date of Patent: September 27, 2011Assignee: MedImmune LimitedInventors: Qing Zhou, Stephen Charles Emery, Paul Elvin
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Publication number: 20110230763Abstract: A targeting catheter is used to locate an arteriotomy, such as is formed during a femoral artery catheterization procedure. The targeting catheter includes one or more targeting aids, such as an inflatable balloon or sensor (e.g., Doppler or temperature sensor), to locate the arteriotomy. The targeting aid may be positioned at the arteriotomy. An ultrasonic beacon on the catheter may then be located relative to a therapeutic ultrasonic applicator (e.g., by using acoustic time-of-flight) so that the focus of ultrasonic energy from the applicator can be aligned with the arteriotomy.Type: ApplicationFiled: May 27, 2011Publication date: September 22, 2011Applicant: Kona Medical, Inc.Inventors: Charles Emery, Larry Augustine, Robyn Lahman, David M. Perozek, Jimin Zhang
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Publication number: 20110230796Abstract: A targeting catheter is used to locate an arteriotomy, such as is formed during a femoral artery catheterization procedure. The targeting catheter includes one or more targeting aids, such as an inflatable balloon or sensor (e.g., Doppler or temperature sensor), to locate the arteriotomy. The targeting aid may be positioned at the arteriotomy. An ultrasonic beacon on the catheter may then be located relative to a therapeutic ultrasonic applicator (e.g., by using acoustic time-of-flight) so that the focus of ultrasonic energy from the applicator can be aligned with the arteriotomy.Type: ApplicationFiled: May 27, 2011Publication date: September 22, 2011Applicant: Kona Medical, Inc.Inventors: Charles Emery, Larry Augustine, Robyn Lahman, David M. Perozek, Jimin Zhang
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Patent number: 7973140Abstract: Antibodies directed to the antigen Ang-2 and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen Ang-2. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.Type: GrantFiled: December 19, 2005Date of Patent: July 5, 2011Assignee: MedImmune LimitedInventors: Larry L. Green, Qing Zhou, Bruce A. Keyt, Xiao-Dong Yang, Stephen Charles Emery, David Charles Blakey