Abstract: An ejector mechanism of a droplet delivery device includes a piezoelectric actuator coupled to an acoustic horn and an aperture plate including a plurality of openings. At least the fluid entrance side of one or more of the plurality of openings is configured to provide a surface contact angle of less than 90 degrees and the piezoelectric actuator is operable to oscillate the aperture plate at a frequency to thereby generate an ejected stream of droplets such that at least about 50% of the droplets have an average ejected droplet diameter of less than about 6 microns during use. A sealing mechanism is provided at an interface of the aperture plate and a detachable fluid cartridge.

Abstract: An electronic droplet delivery device includes a housing including a mouthpiece located at an airflow exit side of the housing, a fluid reservoir, an aperture plate having a plurality of openings that receives fluid from the reservoir, an electronic actuator that oscillates the aperture plate to generate an ejected stream of droplets, and an ejector closure that opens and closes to help seal and prevent evaporation from the aperture plate when the droplet delivery device is not being used.

Abstract: An electronically actuated droplet delivery device includes a housing with a removable mouthpiece that provides a level of air resistance and is interchangeable with alternative mouthpieces that provide alternative levels of air resistance. The level of air resistance can be customized to a particular user of the droplet delivery device by using air resistance elements having different sizes and/or numbers of openings that correspond to different internal air resistance for a droplet deliver device.

Abstract: A method for controlling dosing of droplet delivery device includes providing a droplet delivery device, such as an inhaler, to a user, verifying a location of the user with the droplet delivery device, such as by GPS, and enabling dosing of the drug in droplets ejected from the device based on the verifying of the location of the user.

Abstract: A droplet delivery device, such as for providing aerosol to the respiratory system of an individual via inhalation, including includes an ejector mechanism in fluid communication with a reservoir that provides a constant fluid supply so that the droplet delivery device can be used to administer droplets in the device airflow in multiple orientations.

Abstract: An electronically actuated droplet delivery device includes a housing with an airflow exit at a mouthpiece and an airflow entrance in fluid communication with the airflow exit via an airflow channel. An aperture plate coupled to an electronic actuator energized by a power source produces a droplet plume from a fluid reservoir in fluid communication with the aperture plate. A change of airflow trajectory in the airflow channel and/or a fan provides inertial filtering and removal of droplets in the plume that have a mass mean aerodynamic diameter greater than 5 ?m.

Abstract: An aerosol delivery device includes a piezoelectric transducer that is indirectly coupled to an ejector plate, such as by a membrane between the transducer and ejector plate. A spring force is applied between the ejector plate and transducer in different configurations by a suspension gasket, a compression spring, or flat spring. The spring force optimizes the production and ejection of droplets from fluid supplied to the ejector plate when the transducer vibrates to produce aerosol from the device.

Abstract: A droplet delivery device includes a housing with a mouthpiece port or outlet from a nasal device for releasing fluid droplets, a fluid reservoir, and an ejector bracket having a membrane positioned between a mesh with a plurality of openings and a vibrating member that is coupled to an electronic transducer, such as an ultrasonic transducer. The transducer vibrates the vibrating member which causes the membrane to push fluid supplied by the reservoir through the mesh to generate droplets in an ejected stream released through the outlet.

Abstract: A nasal droplet delivery device for delivering a stream of fluid droplets to nasal passageways and sinus cavities includes an ejector mechanism with an oscillation actuator that vibrates an aperture plate with a plurality of openings to generate an ejected stream of droplets from fluid with one or more active agents. The ejector mechanism does not elevate in-situ temperatures or forces that decompose or denature the one or more active agents in the fluid.

Abstract: A fluid reservoir of a droplet delivery device includes a shell, such as a hard shell, containing a flexible ampoule with liquid in the ampoule. The flexible ampoule releases liquid for ejection from the droplet delivery device when the fluid reservoir is coupled to the droplet delivery device.

Abstract: An electronically actuated droplet delivery device with a mouthpiece for inhaling fluid droplets, an ejector mechanism with a fluid reservoir combined in a removable module with an aperture having a plurality of openings formed through its thickness configured to generate an ejected stream of droplets, and an electronic actuator operably coupled to oscillate the aperture plate at a frequency that generates an ejected stream of droplets.

Abstract: A droplet delivery device and related methods for delivering a low surface tension composition as a stream of droplets to a subject for pulmonary use is disclosed. The droplet delivery device includes an in-line housing, a reservoir, and an ejector mechanism. The ejector mechanism includes an electronic actuator and an aperture plate, the aperture plate having a plurality of openings, and the electronic actuator is operable to oscillate the aperture plate at a frequency to thereby generate the ejected stream of droplets wherein at least about 50% of the droplets have an average ejected droplet diameter of less than about 6 microns.

Abstract: An electronically actuated droplet delivery device includes a housing with an airflow exit at a mouthpiece and an airflow entrance in fluid communication with the airflow exit via an airflow channel. An aperture plate coupled to an electronic actuator energized by a power source produces a droplet plume from a fluid reservoir in fluid communication with the aperture plate. A change of airflow trajectory in the airflow channel and/or a fan provides inertial filtering and removal of droplets in the plume that have a mass mean aerodynamic diameter greater than 5 ?m.

Abstract: An electronically actuated droplet delivery device with a mouthpiece for inhaling fluid droplets includes an ejector mechanism having an electronic actuator operably coupled to an aperture plate. A fluid reservoir provided fluid to the ejector mechanism through a surface tension plate that increases contact between the fluid from the fluid reservoir and the aperture plate.

Abstract: An electronically actuated droplet delivery device includes a housing with a removable mouthpiece that provides a level of air resistance and is interchangeable with alternative mouthpieces that provide alternative levels of air resistance. The level of air resistance can be customized to a particular user of the droplet delivery device by using air resistance elements having different sizes and/or numbers of openings that correspond to different internal air resistance for a droplet deliver device.

Abstract: A method for controlling dosing of droplet delivery device includes providing a droplet delivery device, such as an inhaler, to a user, verifying a location of the user with the droplet delivery device, such as by GPS, and enabling dosing of the drug in droplets ejected from the device based on the verifying of the location of the user.

Abstract: An electronic droplet delivery device includes a housing including a mouthpiece located at an airflow exit side of the housing, a removable fluid reservoir, an aperture plate having a plurality of openings that receives fluid from the reservoir, an electronic actuator that oscillates the aperture plate to generate an ejected stream of droplets, and an electronic chip coupled to the fluid reservoir that communicates information applicable to use of the droplet delivery device with the fluid reservoir.

Abstract: A droplet delivery device includes an ejection channel and droplets outlet, a mesh positioned in the ejection channel and configured to produce an ejected stream of droplets through openings in the mesh, an airflow path in communication with the ejection channel and the mesh, and a heating element positioned in the airflow path.

Abstract: A droplet delivery device includes an ejector bracket including a mesh with a membrane operably coupled to a vibrating member tip that is coupled to an electronic transducer with the membrane between and contacting both the vibrating member tip and the mesh to produce droplets, such as for inhalation by a user of the droplet delivery device.

Abstract: A droplet delivery device includes an ejector mesh communicating with a fluid reservoir via a first pathway that includes wicking material and a second pathway that is free of wicking material with droplets produced by the mesh ejected out of a droplets outlet of the device.