Patents by Inventor Charles Everett Merryman

Charles Everett Merryman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing diverse libraries of encoded polypeptides
    Publication number: 20030022213
    Abstract: tRNA analogues which comprise a tRNA, such as tRNAphe; an amino acid moiety which acts as an acceptor substrate, but not as a donor substrate, for ribosome-directed peptidyl transfer and, thus, is stably linked to the acceptor stem of the tRNA; and a reactive or activatible moiety near or within the anticodon stem loop of the tRNA that can medidate the covalent coupling of the tRNA analogue to mRNA. Also described are polypeptide-tRNA analogue-mRNA fusions; libraries of encoded polypeptides; methods of producing and screening the libraries; and target members and their uses.
    Type: Application
    Filed: June 19, 2002
    Publication date: January 30, 2003
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: Charles Everett Merryman, David P. Bartel
  • Method for producing diverse libraries of encoded polypeptides
    Patent number: 6440695
    Abstract: tRNA analogues which comprise a tRNA, such as tRNAphe; an amino acid moiety which acts as an acceptor substrate, but not as a donor substrate, for ribosome-directed peptidyl transfer and, thus, is stably linked to the acceptor stem of the tRNA; and a reactive or activatible moiety near or within the anticodon stem loop of the tRNA that can medidate the covalent coupling of the tRNA analogue to mRNA. Also described are polypeptide-tRNA analogue-mRNA fusions; libraries of encoded polypeptides; methods of producing and screening the libraries; and target members and their uses.
    Type: Grant
    Filed: April 14, 1999
    Date of Patent: August 27, 2002
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Charles Everett Merryman, David P. Bartel
  • METHOD FOR PRODUCING DIVERSE LIBRARIES OF ENCODED POLYPEPTIDES
    Publication number: 20020031762
    Abstract: tRNA analogues which comprise a tRNA, such as tRNAphe; an amino acid moiety which acts as an acceptor substrate, but not as a donor substrate, for ribosome-directed peptidyl transfer and, thus, is stably linked to the acceptor stem of the tRNA; and a reactive or activatible moiety near or within the anticodon stem loop of the tRNA that can medidate the covalent coupling of the tRNA analogue to mRNA. Also described are polypeptide-tRNA analogue-mRNA fusions; libraries of encoded polypeptides; methods of producing and screening the libraries; and target members and their uses.
    Type: Application
    Filed: April 14, 1999
    Publication date: March 14, 2002
    Inventors: CHARLES EVERETT MERRYMAN, DAVID P. BARTEL