Patents by Inventor Charles F. Barfknecht

Charles F. Barfknecht has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ocular protein stimulants
    Patent number: 5961987
    Abstract: Tear production stimulants of reduced basicity prepared from cyclopropyl adducts of tertiary amines are disclosed.
    Type: Grant
    Filed: October 31, 1996
    Date of Patent: October 5, 1999
    Assignee: University of Iowa Research Foundation
    Inventors: Ronald D. Schoenwald, Charles F. Barfknecht
  • Tetrahydroquinoline analogues for use in glaucoma treatment
    Patent number: 5776482
    Abstract: Tetrahydroquinoline analogues and compositions containing them for topically treating glaucoma to effectively reduce intraocular eye pressure.
    Type: Grant
    Filed: March 29, 1996
    Date of Patent: July 7, 1998
    Assignee: University of Iowa Research Foundation
    Inventors: Ronald D. Schoenwald, Charles F. Barfknecht
  • Topical use of ethyl ethacrynate for glaucoma treatment
    Patent number: 5654335
    Abstract: A method of reducing intraocular eye pressure by topically applying to an affected eye a small but therapeutically effective intraocular eye pressure reducing amount of the compound ethyl ethacrynate.
    Type: Grant
    Filed: February 23, 1996
    Date of Patent: August 5, 1997
    Assignee: University of Iowa Research Foundation
    Inventors: Ronald D. Schoenwald, Charles F. Barfknecht
  • Hexose and pentose prodrugs of ethacrynic acid
    Patent number: 5565434
    Abstract: A method of reducing intraocular eye pressure by topically applying to an affected eye a small but therapeutically effective intraocular eye pressure reducing amount of a compound which is a 2-deoxyglucose or hexose or pentose derivative of ethacrynic acid.
    Type: Grant
    Filed: February 23, 1996
    Date of Patent: October 15, 1996
    Assignee: University of Iowa Research Foundation
    Inventors: Charles F. Barfknecht, Ronald D. Schoenwald
  • Use of sigma receptor ligands as salivary gland stimulants
    Patent number: 5387614
    Abstract: A method of stimulation salivary secretion comprising oral administration of certain sigma ligands which may be generally described as N,N-disubstituted phenylalkylamines.
    Type: Grant
    Filed: July 27, 1993
    Date of Patent: February 7, 1995
    Assignee: University of Iowa Research Foundation
    Inventors: Ronald D. Schoenwald, Charles F. Barfknecht
  • 1-aza-1-arylcycloalkanes as topical glaucoma treatment agents
    Patent number: 5382576
    Abstract: Topical treatments for glaucoma using 1-Aza-1-arylcyloalkanes as the treatment agents.
    Type: Grant
    Filed: July 26, 1993
    Date of Patent: January 17, 1995
    Assignee: University of Iowa Research Foundation
    Inventors: Ronald D. Schoenwald, Charles F. Barfknecht
  • Antiglaucoma drug composition and method
    Patent number: 5322859
    Abstract: Use of sigma agonists as ophthlamic drugs for lowering intraocular pressure.
    Type: Grant
    Filed: February 8, 1993
    Date of Patent: June 21, 1994
    Assignee: University of Iowa Research Foundation
    Inventors: Ronald D. Schoenwald, Charles F. Barfknecht
  • Treatment of psychosis using cyclohexyl-phenyl-lower alkyl amine derivatives
    Patent number: 5256698
    Abstract: The method and composition for treating psychotic disorders with psychoactive drugs which bind at the sigma binding site and act as antagonists to inhibiting psychotic action. The preferred compounds are N-cyclohexyl-N-ethyl benzylamine, N-cyclohexyl-N-ethyl 2-phenylethylamine, and bromhexine.
    Type: Grant
    Filed: July 24, 1990
    Date of Patent: October 26, 1993
    Assignee: University of Iowa Research Foundation
    Inventors: Ronald D. Schoenwald, Charles F. Barfknecht, Roger E. Newton
  • Methazolamide-derived carbonic anhydrase inhibitors
    Patent number: 5225424
    Abstract: N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)ylidene] -2-acetyloxyacetamide, commonly referred to as acetylhydroxymethazolamide and is a water soluble pharmacologically active carbonic anhydrase inhibitor.
    Type: Grant
    Filed: October 21, 1992
    Date of Patent: July 6, 1993
    Assignee: University of Iowa Research Foundation
    Inventors: Ronald D. Schoenwald, Charles F. Barfknecht
  • Anti-inflammatory for use in external and internal eye inflammations
    Patent number: 5179124
    Abstract: An anti-inflammatory drug which is phenylacetic acid derivative and methods of using the same in topically controlling eye inflammations. The preferred drug is 2-[4(2-hydroxypropoxy)phenyl]propionic acid.
    Type: Grant
    Filed: October 1, 1990
    Date of Patent: January 12, 1993
    Assignee: University of Iowa Research Foundation
    Inventors: Ronald D. Schoenwald, Charles F. Barfknecht
  • Analogs of carbonic anhydrase inhibitors and their use as topical IOP inhibitors
    Patent number: 5157044
    Abstract: Analogs are prepared of the carbonic anhydrase inhibitors methazolamide, and dichlorphenamide. The analogs link a cleavable functional group to the pharmacologically active carbonic anhydrase inhibitor resulting in compounds of improved corneal permeability, which are non-irritable to the eye and which are effective topically to inhibit intraocular pressure.
    Type: Grant
    Filed: June 11, 1990
    Date of Patent: October 20, 1992
    Assignee: University of Iowa Research Foundation
    Inventors: Ronald D. Schoenwald, Charles F. Barfknecht
  • Topical ophthalmic imino substituted 2-imino-3-methyl-delta4-1,3,4-thiadiazoline-5-sulfonamides carbonic anhydrase inhibitors
    Patent number: 5104887
    Abstract: High potency carbonic anhydrase inhibitors derived from methazolamide.
    Type: Grant
    Filed: August 28, 1991
    Date of Patent: April 14, 1992
    Assignee: University of Iowa Research Foundation
    Inventors: Ronald D. Schoenwald, Charles F. Barfknecht
  • Prodrugs of carbonic anhydrase inhibitors
    Patent number: 5095026
    Abstract: Prodrugs are prepared of the carbonic anhydrase inhibitors 2-benzothiazolesulfonamide, hydroxymethazolamide, and dichlorphenamide. The prodrugs link a water soluble compound to the pharmacologically active carbonic anhydrase inhibitor through an enzymatically or hydrolytically degradable bond.
    Type: Grant
    Filed: September 22, 1989
    Date of Patent: March 10, 1992
    Assignee: University of Iowa Research Foundation
    Inventors: Ronald D. Schoenwald, Charles F. Barfknecht
  • Topical treatment of glaucoma with 2-benzothiazolesulfonamide derivative
    Patent number: 4975449
    Abstract: A topical composition for eye treatment of glaucoma, comprising a small but pharmaceutically effective amount of an analog of benzothiazole-2-sulfonamide. The most preferred compound is 6-chloro-benzothiazole-2-sulfonamide. The invention also relates to a method of topically treating glaucoma with eye drops to reduce intraocular pressure. Finally, disclosed is a method of synthesis of the preferred and highly effective benzothiazole-2-sulfonamide analogs, particularly the 6-chloro-benzothiazole-2-sulfonamide compound.
    Type: Grant
    Filed: February 4, 1983
    Date of Patent: December 4, 1990
    Assignee: University of Iowa Research Foundation
    Inventors: Ronald D. Schoenwald, Charles F. Barfknecht
  • 6-hydroxyethoxy-2-benzothiazolesulfonamide and topical treatment compositions and method for glaucoma
    Patent number: 4975447
    Abstract: A topical composition for eye treatment of glaucoma, comprising a small but pharmaceutically effective amount of an analog of benzothiazole-2-sulfonamide. The most preferred compound is 6-hydroxyethoxy-2-benzothiazolesulfonamide. The invention also relates to a method of topically treating glaucoma with eye drops to reduce intraocular pressure. Finally, disclosed is a method of synthesis of the preferred and highly effective benzothiazole-2-sulfonamide analogs, particularly the 6-hydroxyethoxy-2-benzothiazolesulfonamide compound.
    Type: Grant
    Filed: April 4, 1985
    Date of Patent: December 4, 1990
    Assignee: University of Iowa Research Foundation
    Inventors: Ronald D. Schoenwald, Charles F. Barfknecht
  • 6-amino-2-benzothiazolesulfonamide and topical treatment compositions and method for glaucoma
    Patent number: 4975448
    Abstract: A topical composition for eye treatment of glaucoma, comprising a small but pharmaceutically effective amount of an analog of benzothiazole-2-sulfonamide. The most preferred compound is 6-amino-2-benzothiazolesulfonamide. The invention also relates to a method of topically treating glaucoma with eye drops to reduce intraocular pressure. Finally, disclosed is a method of synthesis of the preferred and highly effective benzothiazole-2-sulfonamide analogs, particularly the 6-amino-2-benzothiazolesulfonamide compound.
    Type: Grant
    Filed: April 4, 1985
    Date of Patent: December 4, 1990
    Assignee: University of Iowa Research Foundation
    Inventors: Ronald D. Schoenwald, Charles F. Barfknecht
  • Topically effective, nonsteroidal drug for use in external and internal eye inflammations
    Patent number: 4968718
    Abstract: A nonsteroidal anti-inflammatory drug which is phenylacetic acid derivative and methods of using the same in topically controlling eye inflammations.
    Type: Grant
    Filed: January 25, 1988
    Date of Patent: November 6, 1990
    Assignee: University of Iowa Research Foundation
    Inventors: Ronald D. Schoenwald, Charles F. Barfknecht
  • Lacrimal secretion stimulant (lss)
    Patent number: 4820737
    Abstract: Ophthalmic compositions useful as tear stimulants when topically applied to the eye for effective treatment of dry eye syndrome.
    Type: Grant
    Filed: March 16, 1988
    Date of Patent: April 11, 1989
    Assignee: University of Iowa Research Foundation
    Inventors: Ronald D. Schoenwald, Charles F. Barfknecht
  • Magnetic resonance (MR) image enhancement compounds for specific areas of the brain
    Patent number: 4656026
    Abstract: An improved imaging technique involving nuclear magnetic resonance. Known drug or neurotransmitter receptor ligands are covalently bound to magnetic resonance image enhancing spin label compounds, such as sterically hindered free radical nitroxide compounds, with the resulting adduct being administered to a patient, and thereafter when the ligand is bound to specific receptor sites in the soft tissue such as the brain, regional tissue area is assessed with nuclear magnetic resonance, allowing diagnostic discrimination.
    Type: Grant
    Filed: December 10, 1984
    Date of Patent: April 7, 1987
    Assignee: University of Iowa Research Foundation
    Inventors: Jeffrey A. Coffman, Charles F. Barfknecht
  • Non-classical topical treatment for glaucoma
    Patent number: 4636515
    Abstract: A topical composition for eye treatment of glaucoma, comprising a small but pharmaceutically effective amount of a non-classical carbonic anhydrase inhibitor. The most preferred compound is methyl acetazolamide. The invention also relates to a method of topically treating glaucoma with eye drops of a non-classical carbonic anhydrase inhibitor to reduce intraocular pressure.
    Type: Grant
    Filed: June 25, 1984
    Date of Patent: January 13, 1987
    Assignee: University of Iowa Research Foundation
    Inventors: Charles F. Barfknecht, Ronald D. Schoenwald