Patents by Inventor Charles F. Bernard

Charles F. Bernard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of intermediates useful in preparing tricyclic compounds
    Patent number: 6495689
    Abstract: Disclosed is a process for preparing a compound having the formula: wherein R, R1, R2, R3, and R4 are independently selected from the group consisting of H, Br, Cl, F, alkyl, or alkoxy.
    Type: Grant
    Filed: June 21, 2001
    Date of Patent: December 17, 2002
    Assignee: Schering Corporation
    Inventors: Charles F. Bernard, Michael Casey, Frank Xing Chen, Denise C. Grogan, Marc Poirier, Robert P. Williams, Yee-Shing Wong, George G. Wu
  • Synthesis of intermediates useful in preparing tricyclic compounds
    Publication number: 20020077331
    Abstract: Disclosed is a process for preparing a compound having the formula: 1
    Type: Application
    Filed: June 21, 2001
    Publication date: June 20, 2002
    Inventors: Charles F. Bernard, Michael Casey, Frank Xing Chen, Denise C. Grogan, Marc Poirier, Robert P. Williams, Yee-Shing Wong, George G. Wu
  • Synthesis of intermediates useful in preparing tricyclic compounds
    Patent number: 6372909
    Abstract: Disclosed is a process for preparing a compound having the formula: wherein R, R1, R2, R3, and R4 are independently selected from the group consisting of H, Br, Cl, F, alkyl, or alkoxy, by (A) reacting a compound having the formula  wherein RA, RC, RD, and RE are independently selected from the group consisting of H, halo, alkyl, or alkoxy, and R5 is aryl or heteroaryl, with a dehydrating agent to produce an imine having the formula: (B) hydrolyzing the imine produced in step (A) to produce the compound having formula (I). Also disclosed are novel intermediates having the formula:  wherein RA, RB, RC, RD, and RE are independently selected from the group consisting of H, halo, alkyl, or alkoxy, and R5 is aryl or heteroaryl.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: April 16, 2002
    Assignee: Schering Corporation
    Inventors: Charles F. Bernard, Michael Casey, Frank Xing Chen, Denise C. Grogan, Marc Poirier, Robert P. Williams, Yee-Shing Wong, George G. Wu
  • Enantioselective alkylation of tricyclic compounds
    Patent number: 6307048
    Abstract: Disclosed is a process for preparing a compound of the formula: wherein X1, X2, X3, X4, and X5 are independently selected from the group consisting of H, halo, alkyl, alkoxy, aryl, and aryloxy, and R is a protecting group, in which a compound having the formula wherein X1, X2, X3, X4, and X5 are as defined above, is treated with the following, in any sequence: (a) a non-nucleophilic strong base; (b) a chiral amino alcohol; and (c) a compound having the formula wherein L is a leaving group and R is as defined above. The compounds made by this process are useful intermediates for preparing compounds that are inhibitors of farnesyl protein transferase.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: October 23, 2001
    Assignee: Schering Corporation
    Inventors: Shen-Chun Kuo, Charles F. Bernard, Frank Xing Chen, Donald Hou, Agnes S. Kim-Meade, George G. Wu