Abstract: A sterile method of simultaneously breaking a number of ampules (22) containing medication and transferring the liquid drug into syringes (58), which include cutting the ampule shipping container (20) in half and enclosing the ampules in a holder (26). Further, cleaning the ampules and breaking the ampule necks (30) with a shear plate (40) struck by a mallet (44). Finally, transferring the medication with a filtered needle (50) to a sterile container (56) and filling the syringes from the container. The method utilizes apparatus which has a holder (26) of the same configuration as the shipping container (20) and a shear plate (40) that fits over the ampule necks (30). The mallet (44) is used to strike the shear plate breaking all of the necks simultaneously. A tray (34) collects the necks and debris and a sweep (46) clears the debris away into a bio-hazard container (62), or the like.