Abstract: Apparatus and method are described for generating single droplets of fluid aterial in the 40 to 1100 micrometer range. A generator needle assembly is provided having a wire selected for insertion in the needle with critical push-fit clearance and a tapered ground pointed end having an acute included angle of less than 15 degrees. The plunger of the syringe is mechanically advanced while telescopically observing the droplet size. A pneumatic collet is used which air strips the droplet without turbulence to produce uniform sized single droplets without the inclusion of satellite droplets.