Patents by Inventor Charles F. Milo
Charles F. Milo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8409605Abstract: A kit for forming a biocompatible material provides a protein solution and a polymer solution including a derivative of a hydrophilic polymer with a functionality of at least three. Upon mixing. the protein solution and the polymer solution cross-link to form a non-liquid, three-dimensional network that degrades over time back to a liquid form. The polymer includes a degradation control region selected to achieve a desired degradation period and a cross-linking group selected to achieve a desired cross-linking period. The kit provides instructions for forming a mixture of the protein solution and polymer solution and for applying the mixture. The mixture serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.Type: GrantFiled: June 3, 2009Date of Patent: April 2, 2013Assignee: Neomend, Inc.Inventors: Olexander Hnojewyj, Charles F. Milo, Gregory M Cruise
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Publication number: 20100099779Abstract: A kit for forming a biocompatible material provides a protein solution and a polymer solution including a derivative of a hydrophilic polymer with a functionality of at least three. Upon mixing. the protein solution and the polymer solution cross-link to form a non-liquid, three-dimensional network that degrades over time back to a liquid form. The polymer includes a degradation control region selected to achieve a desired degradation period and a cross-linking group selected to achieve a desired cross-linking period. The kit provides instructions for forming a mixture of the protein solution and polymer solution and for applying the mixture. The mixture serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.Type: ApplicationFiled: June 3, 2009Publication date: April 22, 2010Inventors: Olexander Hnojewyj, Charles F. Milo, Gregory M. Cruise
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Publication number: 20080175817Abstract: A biocompatible material genus serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.Type: ApplicationFiled: July 23, 2007Publication date: July 24, 2008Inventors: Olexander Hnojewyj, Charles F. Milo, Gregory M. Cruise
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Patent number: 7247314Abstract: A biocompatible material genus serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.Type: GrantFiled: December 2, 2004Date of Patent: July 24, 2007Assignee: Neomend, IncInventors: Olexander Hnojewyj, Charles F. Milo, Gregory M Cruise
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Patent number: 6949114Abstract: Systems and methods convey a closure material into a catheter to seal a puncture site in a blood vessel. The closure material comprises a mixture of first and second components which, upon mixing, undergo a reaction to form a solid closure material composition. The systems and methods assure ease of delivery and effective mixing of the components to create an in situ barrier at the puncture site.Type: GrantFiled: February 9, 2001Date of Patent: September 27, 2005Assignee: NeoMend, Inc.Inventors: Charles F. Milo, Olexander Hnojewyj, Timothy J McCoy, Bruce S Addis
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Patent number: 6899889Abstract: A biocompatible material genus serves as the foundation for multiple material composition species, each adapted to a specific therapeutic indication.Type: GrantFiled: March 7, 2000Date of Patent: May 31, 2005Assignee: NeoMend, Inc.Inventors: Olexander Hnojewyj, Charles F. Milo, Gregory M Cruise
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Publication number: 20040249365Abstract: A pump, includes a pump engine; a compartment adapted to store a fluid, the compartment being disposed at least partially around the pump engine, and a piston disposed within the compartment, the compartment and the engine being configured to cause the piston to travel within the compartment along an arcuate path and to force a volume of the fluid out of the pump.Type: ApplicationFiled: October 14, 2003Publication date: December 9, 2004Applicant: MicroSolutions, Inc.Inventors: Derek J. Harper, Charles F. Milo
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Patent number: 6800085Abstract: An intravascular catheter system for the treatment of occluded blood vessels that includes tissue displacement or hinged expansion members that are movable from a closed to an open position. An actuating assembly may be provided for moving the tissue expansion members between an open and closed position to exert a substantially lateral distal end force upon the region surrounding an occluded blood vessel. The tissue expansion members may stretch apart, tear or otherwise disrupt a vascular occlusion sufficiently to create a pathway that may support the passage or placement of a guidewire or an interventional vascular device across the occlusion or obstruction. Methods of crossing or displacing a vascular occlusion are further provided that include the positioning of a vascular catheter having at least one hinged spreading member positioned at the distal region of the catheter that is responsive to directed force along the longitudinal axis of the catheter.Type: GrantFiled: April 13, 2001Date of Patent: October 5, 2004Assignee: LuMend, Inc.Inventors: Matthew R. Selmon, Charles F. Milo, Robert L. Wynne, Suresh S. Pai, Kent D. Dell, Charles Gresl, Gerald Hansen, E. Richard Hill, III
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Publication number: 20040111080Abstract: Implantable devices and osmotic pump and catheter systems for delivering a pharmaceutical agent to a patient at selectable rates include an impermeable pump housing and a moveable partition disposed within the housing, the partition dividing the housing into an osmotic driving compartment having an open end and a pharmaceutical agent compartment having a delivery orifice. A plurality of semi permeable membranes may be disposed in the open end of the osmotic driving compartment and a number of impermeable barriers may seal selected ones of the plurality of semi permeable membranes from the patient until breached. Breaching one or more of the impermeable barriers increases the surface area of semi permeable membrane exposed to the patient and controllably increases the delivery rate of the pharmaceutical agent through the delivery orifice and catheter.Type: ApplicationFiled: May 29, 2002Publication date: June 10, 2004Applicant: MicroSolutions, Inc.Inventors: Derek J. Harper, Charles F. Milo
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Patent number: 6746462Abstract: An intravascular catheter system for the treatment of occluded blood vessels that includes tissue displacement or hinged expansion members that are movable from a closed to an open position. An actuating assembly may be provided for moving the tissue expansion members between an open and closed position to exert a substantially lateral distal end force upon the region surrounding an occluded blood vessel. The tissue expansion members may stretch apart, tear or otherwise disrupt a vascular occlusion sufficiently to create a pathway that may support the passage or placement of a guidewire or an interventional vascular device across the occlusion or obstruction. Methods of crossing or displacing a vascular occlusion are further provided that include the positioning of a vascular catheter having at least one hinged spreading member positioned at the distal region of the catheter that is responsive to directed force along the longitudinal axis of the catheter.Type: GrantFiled: March 28, 2000Date of Patent: June 8, 2004Assignee: LuMend, Inc.Inventors: Matthew R. Selmon, Charles F. Milo, Robert L. Wynne, Suresh S. Pai, Kent D. Dell, Charles Gresl
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Publication number: 20040077999Abstract: An intravascular catheter system for the treatment of occluded blood vessels that includes tissue displacement or hinged expansion members that are movable from a closed to an open position. An actuating assembly may be provided for moving the tissue expansion members between an open and closed position to exert a substantially lateral distal end force upon the region surrounding an occluded blood vessel. The tissue expansion members may stretch apart, tear or otherwise disrupt a vascular occlusion sufficiently to create a pathway that may support the passage or placement of a guidewire or an interventional vascular device across the occlusion or obstruction. Methods of crossing or displacing a vascular occlusion are further provided that include the positioning of a vascular catheter having at least one hinged spreading member positioned at the distal region of the catheter that is responsive to directed force along the longitudinal axis of the catheter.Type: ApplicationFiled: August 25, 2003Publication date: April 22, 2004Inventors: Matthew R. Selmon, Charles F. Milo, Robert L. Wynne, Suresh S. Pai, Kent D. Dell, Charles Gresl, Gerald Hansen, E. Richard Hill
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Patent number: 6719725Abstract: Total occlusions are crossed by passing a guidewire or other penetrating wire from a point proximal to the occlusion into a subintimal space between the intimal layer and adventitial layer of the blood vessel wall. The wire is advanced to a point distal to the occlusion and thereafter deflected back into the blood vessel lumen, typically using a deflecting catheter which is advanced over the guidewire after it has been positioned within the subintimal space. After the guidewire is returned to the blood vessel lumen, the deflecting catheter may be withdrawn and the guidewire is available for introduction of other interventional and diagnostic catheters.Type: GrantFiled: December 3, 2002Date of Patent: April 13, 2004Assignee: LuMend, Inc.Inventors: Charles F. Milo, Matthew R. Selmon, Richard E. Hill, Fred H. Co, Ronald G. French
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Publication number: 20040015154Abstract: An implantable pump for delivering a pharmaceutical agent includes a pump engine, a piston, a pharmaceutical agent compartment and a rate adjustment assembly. The pharmaceutical agent compartment is configured to enclose a volume of pharmaceutical agent and the piston. When the piston is acted upon by the pump engine, the piston moves within the pharmaceutical agent compartment along a substantially circular path and delivers the pharmaceutical agent. The rate adjustment assembly is configured to enable a selective and reversible increase or decrease of the delivery rate of the pharmaceutical agent.Type: ApplicationFiled: March 11, 2003Publication date: January 22, 2004Applicant: MicroSolutions, Inc.Inventors: Derek J. Harper, Charles F. Milo
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Patent number: 6638247Abstract: An intravascular catheter system for the treatment of occluded blood vessels that includes tissue displacement or hinged expansion members that are movable from a closed to an open position. An actuating assembly may be provided for moving the tissue expansion members between an open and closed position to exert a substantially lateral distal end force upon the region surrounding an occluded blood vessel. The tissue expansion members may stretch apart, tear or otherwise disrupt a vascular occlusion sufficiently to create a pathway that may support the passage or placement of a guidewire or an interventional vascular device across the occlusion or obstruction. Methods of crossing or displacing a vascular occlusion are further provided that include the positioning of a vascular catheter having at least one hinged spreading member positioned at the distal region of the catheter that is responsive to directed force along the longitudinal axis of the catheter.Type: GrantFiled: March 29, 2000Date of Patent: October 28, 2003Assignee: LuMend, Inc.Inventors: Matthew R. Selmon, Charles F. Milo, Robert L. Wynne, Suresh S. Pai, Kent D. Dell, Charles Gresl, Gerald Hansen, E. Richard Hill, III
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Patent number: 6632217Abstract: An implantable osmotic pump for delivering a pharmaceutical agent to a patient includes an osmotic engine, a substantially toroidal compartment disposed at least partially around the osmotic engine and a piston disposed within the compartment. The osmotic engine is configured to cause the piston to travel within the compartment and deliver a dose pharmaceutical agent contained within the compartment when the pump is implanted in an aqueous environment. A dose escalation assembly may be fitted to the pump, the dose escalation assembly being adapted to selectively increase the rate at which the pharmaceutical agent is delivered from the pump.Type: GrantFiled: April 19, 2001Date of Patent: October 14, 2003Assignee: MicroSolutions, Inc.Inventors: Derek J. Harper, Charles F. Milo
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Patent number: 6616652Abstract: An implantable osmotic pump system includes a pre-hydrated semipermeable membrane to reduce the time interval between implantation of the system into the patient and full operation of the pump system. The semipermeable membrane is maintained in a hydrated state prior to implantation by fluid contact with a saline solution maintained in a saturated state by a salt tablet. As the differential osmotic pressure across the hydrated semipermeable membrane is negligible as the saline concentration on both sides of the membrane is the same, the pump system does not operate and does not infuse the pharmaceutical agent as long as this osmotic equipotential state is maintained. When the saturated saline solution is removed from fluid contact with the semipermeable membrane and the system is implanted in a patient, the osmotic pressure differential across the semipermeable membrane increases, thereby causing the pump to immediately begin operation at or near its intended and designed steady state infusion rate.Type: GrantFiled: February 15, 2000Date of Patent: September 9, 2003Assignee: Microsolutions, Inc.Inventors: Derek J. Harper, Charles F. Milo
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Patent number: 6599304Abstract: An intravascular catheter system for the treatment of occluded blood vessels that includes tissue displacement or hinged expansion members that are movable from a closed to an open position. An actuating assembly may be provided for moving the tissue expansion members between an open and closed position to exert a substantially lateral distal end force upon the region surrounding an occluded blood vessel. The tissue expansion members may stretch apart, tear or otherwise disrupt a vascular occlusion sufficiently to create a pathway that may support the passage or placement of a guidewire or an interventional vascular device across the occlusion or obstruction. Methods of crossing or displacing a vascular occlusion are further provided that include the positioning of a vascular catheter having at least one hinged spreading member positioned at the distal region of the catheter that is responsive to directed force along the longitudinal axis of the catheter.Type: GrantFiled: November 19, 1999Date of Patent: July 29, 2003Assignee: LuMend, Inc.Inventors: Matthew R. Selmon, Charles F. Milo, Robert L. Wynne, Suresh S. Pai, Kent D. Dell, Charles Gresl
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Publication number: 20030135202Abstract: An implantable osmotic pump for delivering a pharmaceutical agent to a patient includes an osmotic engine, a substantially toroidal compartment disposed at least partially around the osmotic engine and a piston disposed within the compartment. The osmotic engine is configured to cause the piston to travel within the compartment and deliver a dose pharmaceutical agent contained within the compartment when the pump is implanted in an aqueous environment. A dose escalation assembly may be fitted to the pump, the dose escalation assembly being adapted to selectively increase the rate at which the pharmaceutical agent is delivered from the pump.Type: ApplicationFiled: January 17, 2003Publication date: July 17, 2003Applicant: MicroSolutions, Inc.Inventors: Derek J. Harper, Charles F. Milo
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Publication number: 20030120195Abstract: Total occlusions are crossed by passing a guidewire or other penetrating wire from a point proximal to the occlusion into a subintimal space between the intimal layer and adventitial layer of the blood vessel wall. The wire is advanced to a point distal to the occlusion and thereafter deflected back into the blood vessel lumen, typically using a deflecting catheter which is advanced over the guidewire after it has been positioned within the subintimal space. After the guidewire is returned to the blood vessel lumen, the deflecting catheter may be withdrawn and the guidewire is available for introduction of other interventional and diagnostic catheters.Type: ApplicationFiled: December 3, 2002Publication date: June 26, 2003Applicant: LUMEND, INC.Inventors: Charles F. Milo, Matthew R. Selmon, Richard E. Hill, Fred H. Co, Ronald G. French
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Publication number: 20030100921Abstract: Systems and methods convey a closure material into a catheter, e.g., to seal a puncture site in a blood vessel. The closure material comprises a mixture of first and second components, which, upon mixing, undergo a reaction to form solid closure material composition. The first component may be a lyophilized polyethylene glycol (PEG) material contained within a vial. The second component may be a buffered albumin solution plus water contained within a syringe. An applicator provides easy and effective mixing of the components and delivery of the mixture to the puncture site.Type: ApplicationFiled: May 8, 2002Publication date: May 29, 2003Applicant: NeoMend, Inc.Inventors: Bruce Addis, Charles F. Milo, Olexander Hnojewyj