Abstract: Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.

Abstract: Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.

Abstract: The present invention provides novel cycloalkyl-substituted pyrimidine dione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.

Abstract: This method comprises steps of: a) partitioning (10, 16) the spectrum of the noisy signal into a HF part and a LF part; b) operating denoising processes in a differentiated manner for each of the two parts of the spectrum with, for the HF part, a denoising by prediction of the useful signal from one sensor to the other between sensors of a first sub-array (R1), by means of a first adaptive algorithm estimator (14), and, for the LF part, a denoising by prediction of the noise from one sensor to the other between sensors of a second sub-array (R2), by means of a second adaptive algorithm estimator (18); c) reconstructing the spectrum by combining together (22) the signals delivered after denoising of the two parts of the spectrum, respectively; and d) selectively reducing the noise (24) by an Optimized Modified Log-Spectral Amplitude gain, OM-LSA, process.

Abstract: This method comprises the following steps in the frequency domain: a) estimating a probability that speech is present; b) estimating a spectral covariance matrix of the noise picked up by the sensors, this estimation being modulated by the probability that speech is present; c) estimating the transfer functions of the acoustic channels between the source of speech and at least some of the sensors relative to a reference constituted by the signal picked up by one of the sensors, this estimation being modulated by the probability that speech is present; d) calculating an optimal linear projector giving a single combined signal from the signals picked up by at least some of the sensors, from the spectral covariance matrix, and from the estimated transfer functions; and e) on the basis of the probability that speech is present and of the combined signal output from the projector, selectively reducing the noise by applying variable gain.

Abstract: Method and system for tagging and tracking donation transactions through accounting means between financial and non-financial entities, method comprising steps of accepting registration of one or more users to the System, accepting a donation transaction via Collection Point, capturing data related to the circumstances, type and quantum of a donation transaction, generating a Tracking Reference upon completion of the donation transaction, delivering a receipt for the donation transaction, in which is embedded the tracking reference for the associated donation, tracking the progress of the donation transaction between financial and non-financial entities by means of the interlinked transmission and receipt of reports, accepting inquiries as to the status or history of the donation transactions by reference to a cited tracking reference, accepting inquiries as to the status or history or delivery of the associated donation value by reference to a cited tracking reference and delivering reports in response to su

Abstract: This method comprises the following steps in the frequency domain: a) estimating a probability that speech is present; b) estimating a spectral covariance matrix of the noise picked up by the sensors, this estimation being modulated by the probability that speech is present; c) estimating the transfer functions of the acoustic channels between the source of speech and at least some of the sensors relative to a reference constituted by the signal picked up by one of the sensors, this estimation being modulated by the probability that speech is present; d) calculating an optimal linear projector giving a single combined signal from the signals picked up by at least some of the sensors, from the spectral covariance matrix, and from the estimated transfer functions; and e) on the basis of the probability that speech is present and of the combined signal output from the projector, selectively reducing the noise by applying variable gain.

Abstract: A basic facial and body treatment cosmetic formulation is a combination of a cationic emulsifying agent, an oil soluble liquid polymer and a naturally occurring lactate buffer system. The basic formulation is a starter system that can be specialized to skin moisturizers, skin lighteners, skin pigmenting agents, sunscreens, antioxidants, line reducing products, wrinkle reducing products, anti-cellulite products, pharmaceuticals and the like.

Abstract: This gearbox assembly (50) for a lawnmower (10) includes a gearbox housing (56) having a horizontal input shaft (62) and a vertical output shaft (64). A lawnmower deck (12) is disposed below the gearbox housing (56) and a spindle housing (55) is mounted to the lawnmower deck (12) and the spindle housing includes a passage (57) communicating with the gearbox housing (56). The output shaft (64) extends below the gearbox housing (56) and into the spindle housing (55). The input shaft (62) has a bevel gear (76) which meshes with a bevel gear (78) on the output shaft for driving (74). The output shaft (64) includes spaced bearings (70 and 72) within the gearbox housing (56) and a bearing (74) within the spindle housing (55). Brackets (28 and 30) are attached between the gearbox housing (56) and the lawnmower deck (12) and the spindle housing (55) is attached to the lawnmower deck (12) separately from the gearbox housing (56).

Abstract: This boat lift drive is used for raising and lowering a wide range of boat size. The boat drive is a two stage worm system and uses a drive motor having a motor shaft driving a first worm and a first worm wheel as a first stage, and driving a second worm and a second worm wheel, as second stage. At least one of said worm shafts has a copper alloy intermediate worm portion. A third stage is provided having a spool driven by the second worm wheels, the spool having a cable disposed thereabout for lifting the boat.

Abstract: Method and system for tagging and tracking donation transactions through accounting means between financial and non-financial entities, method comprising steps of accepting registration of one or more users to the System, accepting a donation transaction via Collection Point, capturing data related to the circumstances, type and quantum of a donation transaction, generating a Tracking Reference upon completion of the donation transaction, delivering a receipt for the donation transaction, in which is embedded the tracking reference for the associated donation, tracking the progress of the donation transaction between financial and non-financial entities by means of the interlinked transmission and receipt of reports, accepting inquiries as to the status or history of the donation transactions by reference to a cited tracking reference, accepting inquiries as to the status or history or delivery of the associated donation value by reference to a cited tracking reference and delivering reports in response to su

Abstract: Apparatus and a method of detecting combustor rumble in a gas turbine engine having combustion equipment that is susceptible to combustor rumble. The method has steps of: locating a dynamic pressure transducer remotely from the combustion equipment; connecting a conduit between the transducer and a location in the engine remote from the combustion equipment and subject to pressure fluctuations due to the combustor rumble; and measuring the pressure fluctuations using the transducer to detect combustor rumble.

Abstract: A basic facial and body treatment cosmetic formulation is a combination of a cationic emulsifying agent, an oil soluble liquid polymer and a naturally occurring lactate buffer system. The basic formulation is a starter system that can be specialized to skin moisturizers, skin lighteners, skin pigmenting agents, sunscreens, antioxidants, line reducing products, wrinkle reducing products, anti-cellulite products, pharmaceuticals and the like.

Abstract: Disclosed are methods and compositions for increasing tissue oxygen levels by administration of superoxygenated compositions of tissue surfaces. The methods are applicable to treatment of a wide variety of conditions including burns, bedsores, ulcers, necrosis and anaerobic infections.

Abstract: A basic facial and body treatment cosmetic formulation is a combination of a cationic emulsifying agent, an oil soluble liquid polymer and a naturally occurring lactate buffer system. The basic formulation is a starter system that can be specialized to skin moisturizers, skin lighteners, skin pigmenting agents, sunscreens, antioxidants, line reducing products, wrinkle reducing products, anti-cellulite products, pharmaceuticals and the like.

Abstract: This gearbox assembly (50) for a lawnmower (10) includes a gearbox housing (56) having a horizontal input shaft (62) and a vertical output shaft (64). A lawnmower deck (12) is disposed below the gearbox housing (56) and a spindle housing (55) is mounted to the lawnmower deck (12) and the spindle housing includes a passage (57) communicating with the gearbox housing (56). The output shaft (64) extends below the gearbox housing (56) and into the spindle housing (55). The input shaft (62) has a bevel gear (76) which meshes with a bevel gear (78) on the output shaft for driving (74). The output shaft (64) includes spaced bearings (70 and 72) within the gearbox housing (56) and a bearing (74) within the spindle housing (55). Brackets (28 and 30) are attached between the gearbox housing (56) and the lawnmower deck (12) and the spindle housing (55) is attached to the lawnmower deck (12) separately from the gearbox housing (56).

Abstract: The present invention is a hollow body stringed musical instrument that utilizes a low mass, soundboard having a 12 to 25 foot radius dome configuration. The soundboard is made of a three ply torsion box design utilizing a honeycomb stiffening layer as the central core. Linear adjustable tuning braces are incorporated in the hollow body. The side and back of the instrument are also of a three ply construction having a polymer ir inorganic foam as the central layer. (Preferably this will be a closed cell foam.) The back also has a domed configuration with a 12 to 15 foot radius. All structural braces are eliminated from the interior of the instrument's body.

Abstract: A method and system in a computerized health care environment for determining whether a consumable may be safely administered to a body site of a patient is provided. A patient identifier to identify a patient and a consumable identifier identifying a consumable are received. A body site identifier identifying a location on the body of the patient to which the attachment is to be placed is received. The patient identifier, consumable identifier and body site identifier are utilized to determined whether the consumable may be safely administered to the body site of the patient.

Abstract: A method and system in a computerized health care environment for determining whether an attachment may be safely attached to a body site of a patient is provided. A patient identifier is received and the patient's electronic medical record is accessed. An attachment identifier is received and data for the attachment is accessed. A body site identifier identifying the area of the body of the patient to which the attachment is to be placed is received and data for the body site is accessed. Some or all of the data are used to determine whether the attachment may be safely attached to the body site of the patient.

Abstract: A system method for determining whether a location on a patient's body is available for an attachment is provided. A patient identifier is received and the patient's electronic medical record is accessed. An interactive graphical representation of at least a portion of a human body is displayed. A selection of a location of the patient's body from the interactive graphical human body representation is received and it is determined whether the location is available for an attachment.