Patents by Inventor Charles Francavilla
Charles Francavilla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10988705Abstract: A method of remediating pesticides from an agricultural oil includes mixing a reaction solvent, a reducing agent, and an agricultural oil into a reaction mixture in a reaction vessel, controlling the temperature of the reaction mixture, producing a pre-neutralization mixture including a separation solvent, transferring the pre-neutralization mixture into a neutralization reactor that contains a neutralization agent, mixing the pre-neutralization mixture with the neutralization agent and allowing separation into an aqueous layer and a separation solvent layer, draining the aqueous layer, and distilling the separation solvent in the separation solvent layer from the remediated agricultural oils.Type: GrantFiled: March 5, 2020Date of Patent: April 27, 2021Assignee: APTIA ENGINEERING LLCInventors: Shale Martin Flora, Daniel Norman Shelton, Charles Francavilla
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Publication number: 20200291324Abstract: A method of remediating pesticides from an agricultural oil includes mixing a reaction solvent, a reducing agent, and an agricultural oil into a reaction mixture in a reaction vessel, controlling the temperature of the reaction mixture, producing a pre-neutralization mixture including a separation solvent, transferring the pre-neutralization mixture into a neutralization reactor that contains a neutralization agent, mixing the pre-neutralization mixture with the neutralization agent and allowing separation into an aqueous layer and a separation solvent layer, draining the aqueous layer, and distilling the separation solvent in the separation solvent layer from the remediated agricultural oils.Type: ApplicationFiled: March 5, 2020Publication date: September 17, 2020Inventors: SHALE MARTIN FLORA, DANIEL NORMAN SHELTON, CHARLES FRANCAVILLA
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Patent number: 9625744Abstract: The present invention relates generally to systems and methods for cleaning and disinfecting contact lenses. In various respects, the invention is directed to an insulated system that reduces heat loss from catalyzed neutralization of a disinfecting solution resulting in an increased temperature of the disinfection solution during the disinfection process and neutralization of the disinfection solution. The increased temperature increases the kill rate (i.e., better reduction) of microorganisms present on the lenses, and increases the neutralization rate of the disinfection solution. Increase of the kill rate allows better reduction of microorganisms resistant to elimination using previous systems and methods, (e.g., Acanthamoeba cysts), and decreases the amount of time as compared to previous systems and methods necessary to reduce microorganisms to acceptable levels.Type: GrantFiled: October 31, 2014Date of Patent: April 18, 2017Assignee: NovaBay Pharmaceuticals, Inc.Inventors: Charles Francavilla, David Stroman
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Publication number: 20170051842Abstract: The present invention relates generally to a magnetic valve system. Embodiments of the present invention provide a system to minimize the potential for mistakenly dispensing one fluid in place of another or desired fluid. More particularly, embodiments of the present invention provide a magnetic valve, where a bias mechanism is provided to bias the magnetic valve into a closed position, whereby a receptacle having a magnet with a magnetic polarity arranged opposite to that of the magnetic valve exerts a force on the magnetic valve sufficient to over come the bias mechanism, and the magnetic valve slides into an open position or state permitting fluid to flow into the receptacle. When the receptacle is removed, the bias mechanism forces the magnetic valve back into the closed position, where no or minimal fluid is permitted to flow.Type: ApplicationFiled: August 20, 2015Publication date: February 23, 2017Applicant: NOVABAY PHARMACEUTICALS, INC.Inventor: Charles Francavilla
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Patent number: 9248117Abstract: The present application describes compounds of Formula I: which are antimicrobial agents, including antibacterial, disinfectant, antifungal, germicidal and/or antiviral agents.Type: GrantFiled: October 18, 2011Date of Patent: February 2, 2016Assignee: NOVABAY PHARMACEUTICALS, INC.Inventors: Rakesh K. Jain, Timothy Shiau, Charles Francavilla, Eddy Low, Eric Douglas Turtle, Donogh John Roger O'Mahony
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Publication number: 20150118108Abstract: The present invention relates generally to systems and methods for cleaning and disinfecting contact lenses. In various respects, the invention is directed to an insulated system that reduces heat loss from catalyzed neutralization of a disinfecting solution resulting in an increased temperature of the disinfection solution during the disinfection process and neutralization of the disinfection solution. The increased temperature increases the kill rate (i.e., better reduction) of microorganisms present on the lenses, and increases the neutralization rate of the disinfection solution. Increase of the kill rate allows better reduction of microorganisms resistant to elimination using previous systems and methods, (e.g., Acanthamoeba cysts), and decreases the amount of time as compared to previous systems and methods necessary to reduce microorganisms to acceptable levels.Type: ApplicationFiled: October 31, 2014Publication date: April 30, 2015Applicant: NovaBay Pharmaceuticals, Inc.Inventors: Charles Francavilla, David Stroman
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Publication number: 20150007860Abstract: The invention monitors the neutralization process involving hydrogen peroxide solution and a hydrogen peroxide neutralization catalyst and compares measured values with theoretical values. The system monitors the chemical reaction and notifies the user of the neutralization status. In an exemplary embodiment, the initial hydrogen peroxide solution concentration is neutralized with a palladium catalyst after a period of time. A microcontroller analyzes the measurements and displays the neutralization process results using colored LED lights and/or text or images on a LCD display. In one embodiment, an apparatus adapted for use with a cleaning solution used to clean a medical device may include a trigger, a processing device in communication with the trigger, and a display device. The processing device provides a trigger count and the display device communicates with the processing device and displays a message based on the count.Type: ApplicationFiled: September 2, 2014Publication date: January 8, 2015Inventors: Charles Francavilla, Ramin Najafi, Eddy Low, Timothy Shiau, Eric Douglas, Donogh John Roger O'Mahony
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Patent number: 8851091Abstract: The invention monitors the neutralization process involving hydrogen peroxide solution and a hydrogen peroxide neutralization catalyst and compares measured values with theoretical values. The system monitors the chemical reaction and notifies the user of the neutralization status. In an exemplary embodiment, the initial hydrogen peroxide solution concentration is neutralized with a palladium catalyst after a period of time. A microcontroller analyzes the measurements and displays the neutralization process results using colored LED lights and/or text or images on a LCD display. In one embodiment, an apparatus adapted for use with a cleaning solution used to clean a medical device may include a trigger, a processing device in communication with the trigger, and a display device. The processing device provides a trigger count and the display device communicates with the processing device and displays a message based on the count.Type: GrantFiled: February 23, 2012Date of Patent: October 7, 2014Assignee: NovaBay Pharmaceuticals, IncInventors: Charles Francavilla, Ramin Najafi, Eddy Low, Timothy Shiau, Eric Douglas Turtle, Donogh John Roger O'Mahony
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Patent number: 8729112Abstract: This application describes compounds useful as anti-microbial agents, including as antibacterial, disinfectant, antifungal, germicidal or antiviral agents.Type: GrantFiled: November 14, 2012Date of Patent: May 20, 2014Assignee: Novabay Pharmaceuticals, Inc.Inventors: Timothy Shiau, Charles Francavilla, Eddy Low, Eric Douglas Turtle, Donogh John Roger O'Mahony, Rakesh K. Jain
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Patent number: 8722715Abstract: The present application relates to N-chlorinated oxazolidinone, hydantoin and imidazolidinone compounds of Formula I or pharmaceutically acceptable salts thereof, and associated compositions and methods of use as antimicrobial agents.Type: GrantFiled: November 4, 2009Date of Patent: May 13, 2014Assignee: NovaBay PharmaceuticalsInventors: Rakesh K. Jain, Eddy Low, Charles Francavilla, Timothy P. Shiau, Bum Kim, Satheesh K. Nair
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Publication number: 20140094495Abstract: This application describes compounds useful as anti-microbial agents, including as antibacterial, disinfectant, antifungal, germicidal or antiviral agents.Type: ApplicationFiled: November 14, 2012Publication date: April 3, 2014Applicant: NovaBay Pharmaceuticals, Inc.Inventors: Timothy K. Shiau, Charles Francavilla, Eddy Low, Eric Douglas Turtle, Donogh John Roger O'Mahony, Rakesh K. Jain
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Patent number: 8278482Abstract: The present application relates to N-chlorinated cationic compounds of Formula I or a salt thereof, and associated compositions and methods of use as antimicrobial agents.Type: GrantFiled: November 6, 2009Date of Patent: October 2, 2012Assignee: Novabay Pharmaceuticals, Inc.Inventors: Rakesh K. Jain, Eddy Low, Charles Francavilla, Timothy P. Shiau, Satheesh K. Nair
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Publication number: 20120211027Abstract: The invention monitors the neutralization process involving hydrogen peroxide solution and a hydrogen peroxide neutralization catalyst and compares measured values with theoretical values. The system monitors the chemical reaction and notifies the user of the neutralization status. In an exemplary embodiment, the initial hydrogen peroxide solution concentration is neutralized with a palladium catalyst after a period of time. A microcontroller analyzes the measurements and displays the neutralization process results using colored LED lights and/or text or images on a LCD display. In one embodiment, an apparatus adapted for use with a cleaning solution used to clean a medical device may include a trigger, a processing device in communication with the trigger, and a display device. The processing device provides a trigger count and the display device communicates with the processing device and displays a message based on the count.Type: ApplicationFiled: February 23, 2012Publication date: August 23, 2012Inventors: Charles Francavilla, Ramin Najafi, Eddy Low, Timothy Shiau, Eric Douglas Turtle, Donogh John Roger O'Mahony
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Publication number: 20120129793Abstract: The present application describes compounds of Formula I and Formula IA and as disclosed herein, that are useful as anti-microbial agents, including as antibacterial, disinfectant, antifungal, germicidal or antiviral agents.Type: ApplicationFiled: October 18, 2011Publication date: May 24, 2012Inventors: Rakesh K. Jain, Timothy Shiau, Charles Francavilla, Eddy Low, Eric Douglas Turtle, Donogh John Roger O'Mahony
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Patent number: 8088804Abstract: Described herein are N-hydroxyamide antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical compositions compound of Formula (I): or a salt, solvate ti hydrate thereof, wherein A is (a) each indicates a point of attachment.Type: GrantFiled: December 4, 2006Date of Patent: January 3, 2012Assignee: Pfizer Inc.Inventors: Rakesh Kumar Jain, Mikhail Fedorovich Gordeev, Jason Gustaf Lewis, Charles Francavilla
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Patent number: 8044199Abstract: Novel N-formyl hydroxylamine compounds of formula I: wherein R1 is hydrogen, alkyl, heteroaryl, heterocycloalkyl, aryl, heteroaryl or cycloalkyl; R3 is hydrogen, halogen or alkoxy; R4 is pyridazinyl; n is 0 to 3; and wherein one or more of the ring nitrogen heteroatoms of said pyridazinyl is optionally oxidized and their derivatives are disclosed. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and use of the compounds are also disclosed.Type: GrantFiled: June 2, 2009Date of Patent: October 25, 2011Assignee: Vicuron Holdings LLCInventors: Kathryn Rene Bracken, Simon Bushell, Karl Dean, Charles Francavilla, Rakesh K. Jain, Kwangho Lee, Mohindra Seepersaud, Lei Shu, Arathi Sundaram, Zhengyu Yuan
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Publication number: 20110151025Abstract: Disclosed herein are methods and compositions for the treatment or prophylaxis, in a mammal, of bronchopulmonary infections, obstructive pulmonary disease, cystic fibrosis, and ventilator-associated infections. The methods and compositions include a therapeutically effective amount of one or more N-halogenated or N,N-dihalogenated amines, and their analogues, derivatives, or pharmaceutically acceptable salts and esters.Type: ApplicationFiled: April 10, 2009Publication date: June 23, 2011Inventors: Waldemar Gottardi, Markus Nagl, Ramin Najafi, Lu Wang, Rakesh K. Jain, Timothy Shiau, Eddy Low, Charles Francavilla
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Publication number: 20100158818Abstract: The present application relates to N-chlorinated cationic compounds of Formula I or a salt thereof, and associated compositions and methods of use as antimicrobial agents.Type: ApplicationFiled: November 6, 2009Publication date: June 24, 2010Inventors: Rakesh K. Jain, Eddy Low, Charles Francavilla, Timothy P. Shiau, Satheesh K. Nair
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Publication number: 20100137349Abstract: The present application relates to N-chlorinated oxazolidinone, hydantoin and imidazolidinone compounds of Formula I or pharmaceutically acceptable salts thereof, and associated compositions and methods of use as antimicrobial agents.Type: ApplicationFiled: November 4, 2009Publication date: June 3, 2010Inventors: Rakesh K. Jain, Eddy Low, Charles Francavilla, Timothy P. Shiau, Bum Kim, Satheesh K. Nair
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Publication number: 20100063278Abstract: Novel N-formyl hydroxylamine compounds and their derivatives are discloses. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and use of the compounds are also disclosed.Type: ApplicationFiled: June 2, 2009Publication date: March 11, 2010Applicants: Novartis AG, Vicuron Pharmaceuticals, Inc.Inventors: Kathryn Rene Bracken, Simon Bushell, Karl Dean, Charles Francavilla, Rakesh K. Jain, Kwangho Lee, Mohindra Seepersaud, Lei Shu, Arathi Sundaram, Zhengyu Yuan