Abstract: A valve stem for use in an aerosol valve such as a metered dose medicinal aerosol valve is described. The valve stem includes a flattened area around the side hole. The flattened area helps reduce damage to the diaphragm aperture upon repeated actuation of the metered dose inhaler. Also described is a metered dose valve and a metered dose inhaler, each including the flattened valve stem of the present invention.

Abstract: Gaskets for use in a metering valve are described herein. The gaskets include one or more gasket-protective components that are designed to limit the likelihood and extent to which the gasket can intrude into an opening such as the channel opening of a valve stem. The one or more gasket protective-components also limit the likelihood and extent of damage caused by repeated use of the metering valve.

Abstract: A valve stem for use in an aerosol valve such as a metered dose medicinal aerosol valve is described. The valve stem includes a flattened area around the side hole. The flattened area helps reduce damage to the diaphragm aperture upon repeated actuation of the metered dose inhaler. Also described is a metered dose valve and a metered dose inhaler, each including the flattened valve stem of the present invention.

Abstract: A novel powdered medicament dispenser is disclosed. The powder medicament dispenser includes a novel agglomerator for loading the powder from a reservoir to a dispensing mechanism. In another aspect of the invention, a disposable cartridge is disclosed for use with a medicament dispenser having pressurization and actuator assemblies. A novel method of dispensing a powdered medicament, as well as inhalation activated and transmission assemblies are also disclosed.

Abstract: A novel powdered medicament dispenser is disclosed. The powder medicament dispenser includes a novel agglomerator for loading the powder from a reservoir to a dispensing mechanism. In another aspect of the invention, a disposable cartridge is disclosed for use with a medicament dispenser having pressurization and actuator assemblies. A novel method of dispensing a powdered medicament, as well as inhalation activated and transmission assemblies are also disclosed.

Abstract: Metered dose dispensing valves providing good dosage reproducibility with formulations having a propensity to cream and with low concentration formulations. Valves having a tank retaining cup have a small inlet aperture of no more than 0.7 mm and preferably the tank retaining cup follows the configuration of the end of the valve stem. Valves having a bottle emptier attached to the valve stem have a filling channel in the valve stem which protrudes only slightly from the metering chamber when the valve is in its inoperative position.

Abstract: The present invention relates to metering valves and methods for repeatedly delivering a precise amount of a pressurized fluid such as an aerosol. Each metering valve is configured such that the metering chamber exists only upon actuation of the valve stem to dispense a dosage. Thus, the metering chamber is created, filled with aerosol formulation, and emptied during the brief moment that the valve stem is depressed and subsequently released by the user to dispense a dosage. Alternative embodiments of the present invention also include mechanisms for pressure filling an aerosol container through such a metering valve.

Abstract: Microfibrous heparin salts, nonwoven webs of such fibers, a process for preparing the fibers and the use of the webs for the rapid heparinization of blood are disclosed.

Abstract: Microfibrous heparin salts, nonwoven webs of such fibers, a process for preparing the fibers and the use of the webs for the rapid heparinization of blood are disclosed.

Abstract: An aerosol composition capable of dispensing dry particles uniformly in a very fine particle size, comprising solid particles coated with a dry coating of a perfluorinated surfactant, suspended in a propellant. The propellant utilized may be of the perfluorinated environmentally preferred type.

Abstract: A system is disclosed for injecting dry medicaments in a gaseous suspension into the trachea of an animal. The system comprises: needle means for insertion into the trachea and having a passageway for directing the medicament into the trachea; medicament dispenser for dispensing the medicament into the needle means; a mask formed from substantially gas inpermeable material and shaped to fit over the mouth and nose of the animal having an opening for the movement of gas thereto; and regulator means adapted for connection to a supply of compressed gas connected to the mask and the needle means to time the discharge of compressed gas to the mask and the needle means to coincide with the animal's inhalation.