Abstract: An endoscope has an improved chip-on-tip configuration that includes both a first configuration of source illumination fibers and a second plurality of source illumination fibers, along with a camera chip. The combination of the camera chip and the source illumination fibers on the tip of the endoscope results in endoscopes with reduced size and weight.

Abstract: An endoscope has an improved chip-on-tip configuration that includes both a first configuration of source illumination fibers and a second plurality of source illumination fibers, along with a camera chip. The combination of the camera chip and the source illumination fibers on the tip of the endoscope results in endoscopes with reduced size and weight.

Abstract: The present disclosure provides systems and methods for determining the presence of a target material in a sample. In general terms, the system and method disclosed herein provide collecting interacted photons from a sample having a target material. The interacted photons are passed through a tunable filter to a VIS-NIR detector where the VIS-NIR detector generates a VIS-NIR hyperspectral image representative of the filtered interacted photons. The hyperspectral image of the filtered interacted photons is analyzed by comparing the hyperspectral image of the filtered interacted photons to known hyperspectral images to identify the presence of a target material in a sample. The systems and methods disclosed herein provide easy identification of the presence of a target material in a sample.

Abstract: The present disclosure provides systems and methods for determining the presence of a target material in a sample. In general terms, the system and method disclosed herein provide collecting interacted photons from a sample having a target material. The interacted photons are passed through a tunable filter to a VIS-NIR detector where the VIS-NIR detector generates a VIS-NIR hyperspectral image representative of the filtered interacted photons. The hyperspectral image of the filtered interacted photons is analyzed by comparing the hyperspectral image of the filtered interacted photons to known hyperspectral images to identify the presence of a target material in a sample. The systems and methods disclosed herein provide easy identification of the presence of a target material in a sample.

Abstract: The present disclosure provides for a system and method for analyzing a sample comprising at least one unknown material. A first location may be scanned to generate a SWIR hyperspectral image. The SWIR hyperspectral image may be generated using dual polarization techniques. The SWIR hyperspectral image may be analyzed to target a second location comprising the unknown material. This second location may be further analyzed using Raman spectroscopic techniques and a Raman data set may be generated. The Raman data set may be further analyzed to associate the unknown material with a know material.

Abstract: It is important to be able to drag a large animal through the woods after it has been killed. This device will allow the hunter to lift the animal's head above the ground as well as the legs in a pair of openings that will elevate the head of the animal off the ground surface so that the animal may be dragged. The handle may also telescope and will allow more than one hunter to grab the device in order to safely pull the animal through the woods.

Abstract: The present disclosure provides systems and methods for determining the presence of a contaminate in a food sample. Interacted photons from a food sample having a contaminate of interest are collected. The interacted photons are passed through a tunable filter to a hyperspectral detector that generates a hyperspectral image representative of the filtered interacted photons. The hyperspectral image is analyzed by comparing the hyperspectral image obtained from the food sample to known hyperspectral images to identify a contaminate in the food sample. The systems and methods disclosed herein provide an easy and non-destructive tool for identifying contaminates in a food sample.

Abstract: The present disclosure provides systems and methods for determining the presence of a target material in a sample. In general terms, the system and method disclosed herein provide collecting interacted photons from a sample having a target material. The interacted photons are passed through a tunable filter to a VIS-NIR detector where the VIS-NIR detector generates a VIS-NIR hyperspectral image representative of the filtered interacted photons. The hyperspectral image of the filtered interacted photons is analyzed by comparing the hyperspectral image of the filtered interacted phtons to known hyperspectral images to identify the presence of a target material in a sample. The systems and methods disclosed herein provide easy identification of the presence of a target material in a sample.

Abstract: A first location comprising an unknown material may be scanned using SWIR hyperspectral imaging in a dual polarization configuration. Surveying may also be applied to thereby determine whether or not a human is present. This surveying may be achieved my assessing LWIR data, data acquired from motion sensors, and combinations thereof. If no human is present, a second location may be interrogated using Raman spectroscopic techniques to thereby obtain a Raman data set representative of the region of interest. This Raman data set may be assessed to associate an unknown material with a known material. This assessment may be achieved by comparing the Raman data set to one or more reference data sets in a reference database, where each reference data set is associated with a known material.

Abstract: The present disclosure provides for a system and method for analyzing a sample comprising at least one unknown material. A first location may be scanned to generate a SWIR hyperspectral image. The SWIR hyperspectral image may be generated using dual polarization techniques. The SWIR hyperspectral image may be analyzed to target a second location comprising the unknown material. This second location may be further analyzed using Raman spectroscopic techniques and a Raman data set may be generated. The Raman data set may be further analyzed to associate the unknown material with a know material.

Abstract: A method for detecting unknown materials, such as drugs. A first location is surveyed using a video capture device to identify a second location comprising an unknown material. The second location is interrogated using SWIR spectroscopic and/or imaging methods to generate a SWIR hyperspectral image. The SWIR hyperspectral image is analyzed to associate the unknown material with a known drug material. A system for detecting unknown materials, such as drugs comprising a first collection lens for collecting interacted photons from a first location and a visible imaging device for generating a visible image. A second collection lens may collect a plurality of interacted photons from a second location and a tunable filter may filter the interacted photons. A spectroscopic imaging device may detect the interacted photons and generate a SWIR hyperspectral image. A processor may analyze the SWIR hypespectral image to associate an unknown material with a known material.

Abstract: A system and method for detecting environmental conditions using SWIR hyperspectral imaging. A method may comprise collecting a plurality of interacted photons from at least one location and passing the interacted photons through a tunable filter, filtering the interacted photons into a plurality of wavelength bands. These filtered photons may be detected and analyzed to determine the presence or absence of an environmental condition. A system may comprise at least one collection lens configured to collect at least one plurality of interacted photons from at least one location and a tunable filter for filtering the interacted photons into a plurality of wavelength bands. The system may further comprise a detector configured to detect the filtered photons and generate at least one hyperspectral image representative of the location. The system may further comprise a processor for analyzing the hyperspectral data set and determining the presence or absence of an environmental condition.

Abstract: The present invention is directed to a substituted pyrimidine compound of formula (I) or an enantiomer thereof, or a prodrug or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising such a compound. The invention also includes a method of treatment of a patient by the administration of a pharmaceutically effective amount of such a compound.

Abstract: A system and method for depositing a sample of a threat agent is deposited onto a substrate. A first optical collection device collects at least one of the following: elastic scattered light produced by the threat agent, and Raman scattered light produced by the threat agent. A second optical collection device collects Raman scattered light produced by the threat agent, wherein the second optical collection device comprises a two dimensional non-linear array of optical fibers drawn into a one dimensional fiber stack that converts a non-linear field of view into a linear field of view, wherein the one dimensional fiber stack is coupled to an entrance slit of a Raman imaging spectrometer. The threat agent deposited on the substrate is identified.

Abstract: A system and method for depositing a sample of a threat agent onto a substrate. A single illumination source illuminates the threat agent deposited on the substrate with a plurality of photons to thereby produce elastic scattered photons and Raman scattered photons. The threat agent on the substrate is identified. The system and method operate in a trigger mode that detects the presence or absence of the threat agent, and an identification mode that identifies the threat agent.

Abstract: A system method for depositing a sample of a threat agent is deposited onto a substrate. The threat agent is illuminated via an illumination source along an optical path with a plurality of photons to thereby produce photons transmitted, reflected, emitted or Raman scattered by the threat agent. An optical system collects elastic scatter photons produced by the threat agent and at least one of photons transmitted, reflected, emitted or Raman scattered by the threat agent, wherein said illumination source is located along an optical path, and said substrate is located along a plane wherein the optical path is at an angle other than 90° with respect to the substrate plane. The depth of field of the optical system is extended by passing at least one of the following through a phase mask: elastic scattered photons, and photons transmitted, reflected, emitted or Raman scattered by the threat agent.

Abstract: A container for holding a sample and a system and method for a handheld spectrometer using the container is disclosed. In one embodiment, the container includes a vial with an optical window at the base of the vial. A sample may be placed in the vial. A hollow plunger may be slidably inserted into the vial which seals the gap between the plunger and the walls of the vial. The plunger includes a filter element. When the plunger is inserted into the vial, the sample is forced against the optical window and the filter element vents liquid and/or gas that is in the vial into the hollow plunger. A portable or handheld system for detecting, for example, biothreat agents makes use of the container in order to determine a spectrum of the sample. The optical window of the container is preferably substantially transparent to photons illuminating the sample and to photons produced due to the interaction of the illuminating photons and the sample.

Abstract: A chaotic communication system employs transmitting and receiving chaotic oscillating circuits. One improvement to first-generation systems is the ability to modulate a nonreactive element in the transmitting circuit, thus increasing modulation bandwidth. Other features include insertion of a gain control amplifier in a chaotic receiver; signal filtering in chaotic transmitters and receivers; use of chaotic modulation techniques for cellular telephony applications; dual-transmitter and receiver systems; a dual receiver synchronization detector; interfaces to communication systems; analog chaotic signal modulation; use of multiple chaotic transmitters and receivers; digital algorithm improvement using a cube-law nonlinear component; a Gb-only receiver; a Gb-only transmitter; and positive slope transmitter and receiver systems.

Abstract: The present invention is directed to a compound of Formula (I) wherein Cy1, Cy2, L1, L2, and R1 are as defined herein, a pharmaceutical composition comprising a pharmaceutically effective amount of one or more compounds according to Formula (I) in admixture with a pharmaceutically acceptable carrier, and a method of treating a patient suffering from a PGD2-mediated disorder including, but not limited to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ische

Abstract: A container for holding a sample and a system and method for a handheld spectrometer using the container is disclosed. In one embodiment, the container includes a vial with an optical window at the base of the vial. A sample may be placed in the vial. A hollow plunger may be slidably inserted into the vial which seals the gap between the plunger and the walls of the vial. The plunger includes a filter element. When the plunger is inserted into the vial, the sample is forced against the optical window and the filter element vents liquid and/or gas that is in the vial into the hollow plunger. A portable or handheld system for detecting, for example, biothreat agents makes use of the container in order to determine a spectrum of the sample. The optical window of the container is preferably substantially transparent to photons illuminating the sample and to photons produced due to the interaction of the illuminating photons and the sample.