Patents by Inventor Charles Gentile

Charles Gentile has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11944770
    Abstract: An expandable introducer sheath with an interlock dilator. The present technology provides an expandable sheath with a step feature inside its distal opening, and a dilator with an interlock that includes a catch surface configured to engage with the step feature and resist further relative movement so that the body of the dilator is prevented from exiting the distal end of the expandable sheath. This interlocking engagement may allow the dilator to be used to extend and maintain tension on the expandable sheath during insertion into a patient, and then to be retracted from the expandable sheath by pulling the dilator in the opposite direction. The present technology also provides a dilator hub with a spring mechanism configured to achieve and maintain a desired tension on the expandable sheath and to prevent overextension of the expandable sheath when the dilator is being inserted into the expandable sheath.
    Type: Grant
    Filed: April 6, 2023
    Date of Patent: April 2, 2024
    Assignee: Abiomed, Inc.
    Inventors: Christopher N. Korkuch, Robert Fishman, Michael Thomas Finnegan, Charles DeLorenzo, Andrew Gentile, Anne Gabrielle McLoughlin, Robert Swierczek, Matthew D'Agostino, Jonathan Barry
  • Publication number: 20170115241
    Abstract: A method and system for performing material identification and 2D scanning of a room temperature sample using a TES detector.
    Type: Application
    Filed: October 21, 2016
    Publication date: April 27, 2017
    Inventors: Christopher G. Tully, Charles Gentile
  • Patent number: 9318228
    Abstract: A method and apparatus for producing Mo-99 from Mo-100 for the use of the produced Mo-99 in a Tc-99m generator without the use of uranium is presented. Both the method and apparatus employ high energy gamma rays for the transformation of Mo-100 to Mo-99. The high energy gamma rays are produced by exposing a metal target to a moderated neutron output of between 6 MeV and 14 MeV. The resulting Mo-99 spontaneously decays into Tc-99m and can therefore be used in a Tc-99m generator.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: April 19, 2016
    Inventors: Charles A. Gentile, Adam B. Cohen, George Ascione
  • Publication number: 20120275557
    Abstract: A method and apparatus for producing Mo-99 from Mo-100 for the use of the produced Mo-99 in a Tc-99m generator without the use of uranium is presented. Both the method and apparatus employ high energy gamma rays for the transformation of Mo-100 to Mo-99. The high energy gamma rays are produced by exposing a metal target to a moderated neutron output of between 6 MeV and 14 MeV. The resulting Mo-99 spontaneously decays into Tc-99m and can therefore be used in a Tc-99m generator.
    Type: Application
    Filed: April 26, 2012
    Publication date: November 1, 2012
    Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Charles A. Gentile, Adam B. Cohen, George Ascione
  • Publication number: 20110258151
    Abstract: A system for identifying radionuclide emissions is described. The system includes at least one processor for processing output signals from a radionuclide detecting device, at least one training algorithm run by the at least one processor for analyzing data derived from at least one set of known sample data from the output signals, at least one classification algorithm derived from the training algorithm for classifying unknown sample data, wherein the at least one training algorithm analyzes the at least one sample data set to derive at least one rule used by said classification algorithm for identifying at least one radionuclide emission detected by the detecting device.
    Type: Application
    Filed: January 21, 2011
    Publication date: October 20, 2011
    Inventors: Charles A. Gentile, Jason Perry, Stephen W. Langish, Kenneth Silber, William M. Davis, Dana Mastrovito
  • Patent number: 7877340
    Abstract: A system for identifying radionuclide emissions is described. The system includes at least one processor for processing output signals from a radionuclide detecting device, at least one training algorithm run by the at least one processor for analyzing data derived from at least one set of known sample data from the output signals, at least one classification algorithm derived from the training algorithm for classifying unknown sample data, wherein the at least one training algorithm analyzes the at least one sample data set to derive at least one rule used by said classification algorithm for identifying at least one radionuclide emission detected by the detecting device.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: January 25, 2011
    Assignee: Princeton University
    Inventors: Charles A. Gentile, Jason Perry, Stephen W. Langish, Kenneth Silber, William M. Davis, Dana Mastrovito
  • Publication number: 20100280980
    Abstract: A system for identifying radionuclide emissions is described. The system includes at least one processor for processing output signals from a radionuclide detecting device, at least one training algorithm run by the at least one processor for analyzing data derived from at least one set of known sample data from the output signals, at least one classification algorithm derived from the training algorithm for classifying unknown sample data, wherein the at least one training algorithm analyzes the at least one sample data set to derive at least one rule used by said classification algorithm for identifying at least one radionuclide emission detected by the detecting device.
    Type: Application
    Filed: April 16, 2010
    Publication date: November 4, 2010
    Inventors: Charles A. Gentile, Jason Perry, Stephen W. Langish, Kenneth Silber, William M. Davis, Dana Mastrovito
  • Patent number: 7711661
    Abstract: A system for identifying radionuclide emissions is described. The system includes at least one processor for processing output signals from a radionuclide detecting device, at least one training algorithm run by the at least one processor for analyzing data derived from at least one set of known sample data from the output signals, at least one classification algorithm derived from the training algorithm for classifying unknown sample data, wherein the at least one training algorithm analyzes the at least one sample data set to derive at least one rule used by said classification algorithm for identifying at least one radionuclide emission detected by the detecting device.
    Type: Grant
    Filed: May 2, 2007
    Date of Patent: May 4, 2010
    Assignee: The Trustees of Princeton University
    Inventors: Charles A. Gentile, Jason Perry, Stephen W. Langish, Kenneth Silber, William M. Davis, Dana Mastrovito
  • Publication number: 20080061994
    Abstract: A detector for detecting the presence of suspect radionuclides in a target is disclosed. The detector includes a first detection channel for a first detecting neutron emissions in the target and for providing a first output in accordance with the first detecting, a second detection channel for a second detecting x-ray emissions in the target and for providing a second output in accordance with the second detecting, a third detection channel for a third detecting and an identifying of gamma emissions in the target and for providing a third output in accordance with the third detecting and identifying, a signal manipulation electrically coupled to each of the first, second, and third detection channels, the signal manipulation for receiving the first, second and third outputs and for processing those outputs, and at least one processor electrically coupled to the signal manipulation.
    Type: Application
    Filed: May 24, 2007
    Publication date: March 13, 2008
    Inventors: Charles Gentile, Andrew Carpe, Stephen Langish
  • Publication number: 20070294059
    Abstract: A system for identifying radionuclide emissions is described. The system includes at least one processor for processing output signals from a radionuclide detecting device, at least one training algorithm run by the at least one processor for analyzing data derived from at least one set of known sample data from the output signals, at least one classification algorithm derived from the training algorithm for classifying unknown sample data, wherein the at least one training algorithm analyzes the at least one sample data set to derive at least one rule used by said classification algorithm for identifying at least one radionuclide emission detected by the detecting device.
    Type: Application
    Filed: May 2, 2007
    Publication date: December 20, 2007
    Inventors: Charles Gentile, Jason Perry, Stephen Langish, Kenneth Silber, William Davis, Dana Mastrovito
  • Publication number: 20070278415
    Abstract: The present invention is directed toward an apparatus and methods for detection and identification of target radionuclides and threatening radionuclides that may be present in a sample volume. One aspect of the invention discloses a digital computational apparatus that determines similarity or identity to a target radionuclide or a threatening radionuclide. In another aspect, the invention discloses a high throughput apparatus for detection of a target radionuclide in a sample volume, or for identifying a target radionuclide present in a sample volume, or both, that includes a detecting means, an analyzing means, and an identifying means. In a further aspect the invention discloses a high throughput apparatus for communicating the presence of a target radionuclide in a sample volume, the identity of a target radionuclide in a sample volume, or both to appropriate personnel.
    Type: Application
    Filed: March 14, 2007
    Publication date: December 6, 2007
    Inventors: Charles Gentile, Andrew Carpe, Stephen Langish
  • Publication number: 20070170368
    Abstract: The present invention is directed toward an apparatus and methods for detection and identification of target radionuclides and threatening radionuclides that may be present in a sample volume. One aspect of the invention discloses a digital computational apparatus that determines similarity or identity to a target radionuclide or a threatening radionuclide. In another aspect, the invention discloses a high throughput apparatus for detection of a target radionuclide in a sample volume, or for identifying a target radionuclide present in a sample volume, or both, that includes a detecting means, an analyzing means, and an identifying means. In a further aspect the invention discloses a high throughput apparatus for communicating the presence of a target radionuclide in a sample volume, the identity of a target radionuclide in a sample volume, or both to appropriate personnel.
    Type: Application
    Filed: January 31, 2006
    Publication date: July 26, 2007
    Inventors: Charles Gentile, Andrew Carpe, Stephen Langish
  • Patent number: 7244948
    Abstract: The present invention is directed toward an apparatus and methods for detection and identification of target radionuclides and threatening radionuclides that may be present in a sample volume. One aspect of the invention provides a digital computational apparatus that determines similarity or identity to a target radionuclide or a threatening radionuclide. In another aspect, the invention provides a high throughput apparatus for detection of a target radionuclide in a sample volume, or for identifying a target radionuclide present in a sample volume. In a further aspect the invention provides a high throughput apparatus for communicating the presence of a target radionuclide in a sample volume, the identity of a target radionuclide in a sample volume, or both to appropriate personnel.
    Type: Grant
    Filed: January 31, 2006
    Date of Patent: July 17, 2007
    Assignee: Princeton University
    Inventors: Charles A. Gentile, Andrew F. Carpe, Stephen W. Langish
  • Patent number: 6994831
    Abstract: The Oxidative Tritium Decontamination System, OTDS, provides a method and apparatus for reduction of tritium surface contamination on various items. The OTDS employs ozone gas as oxidizing agent to convert elemental tritium to tritium oxide. Tritium oxide vapor and excess ozone gas is purged from the OTDS, for discharge to atmosphere or transport to further process. An effluent stream is subjected to a catalytic process for the decomposition of excess ozone to diatomic oxygen. One of two configurations of the OTDS is employed: dynamic apparatus equipped with agitation mechanism and large volumetric capacity for decontamination of light items, or static apparatus equipped with pressurization and evacuation capability for decontamination of heavier, delicate, and/or valuable items.
    Type: Grant
    Filed: October 23, 2002
    Date of Patent: February 7, 2006
    Assignee: The United States of America as represented by the United States Department of Energy
    Inventors: Charles A. Gentile, Gregory L. Guttadora, John J. Parker
  • Publication number: 20050205799
    Abstract: A detector for detecting the presence of suspect radionuclides in a target is disclosed. The detector includes a first detection channel for a first detecting neutron emissions in the target and for providing a first output in accordance with the first detecting, a second detection channel for a second detecting x-ray emissions in the target and for providing a second output in accordance with the second detecting, a third detection channel for a third detecting and an identifying of gamma emissions in the target and for providing a third output in accordance with the third detecting and identifying, a signal manipulation electrically coupled to each of the first, second, and third detection channels, the signal manipulation for receiving the first, second and third outputs and for processing those outputs, and at least one processor electrically coupled to the signal manipulation.
    Type: Application
    Filed: December 20, 2004
    Publication date: September 22, 2005
    Inventors: Charles Gentile, Lewis Meixler, Stephen Langish
  • Publication number: 20040240509
    Abstract: The present invention is directed toward a window or foil that transmits incident radiation with high efficiency and that is coupled to a cooling means to dissipate heat from radiation losses occurring within the window. In one aspect the invention provides an energy-transmitting system that includes a nonmetallic window and means for cooling the window. In a second aspect the invention provides a laser assembly including a laser cavity enclosed by a wall that has one or more surfaces, wherein at least one surface includes an actively cooled window of the invention. In various embodiments of both the energy-transmitting system and the laser assembly the window includes a dielectric material, or a semiconducting material such as silicon. In addition a corrosion-resistant coating may be deposited on at least one surface of the window.
    Type: Application
    Filed: May 10, 2004
    Publication date: December 2, 2004
    Applicant: Princeton University
    Inventors: Robert Parsells, Charles Gentile
  • Publication number: 20040178339
    Abstract: The present invention is directed toward an apparatus and methods for detection and identification of target radionuclides and threatening radionuclides that may be present in a sample volume. One aspect of the invention discloses a digital computational apparatus that determines similarity or identity to a target radionuclide or a threatening radionuclide. In another aspect, the invention discloses a high throughput apparatus for detection of a target radionuclide in a sample volume, or for identifying a target radionuclide present in a sample volume, or both, that includes a detecting means, an analyzing means, and an identifying means. In a further aspect the invention discloses a high throughput apparatus for communicating the presence of a target radionuclide in a sample volume, the identity of a target radionuclide in a sample volume, or both to appropriate personnel.
    Type: Application
    Filed: March 6, 2003
    Publication date: September 16, 2004
    Applicant: The Trustees of Princeton University
    Inventors: Charles Gentile, George Ascione, Andrew Carpe, Stephen Langish, John Parker