Patents by Inventor Charles Gentile
Charles Gentile has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11944770Abstract: An expandable introducer sheath with an interlock dilator. The present technology provides an expandable sheath with a step feature inside its distal opening, and a dilator with an interlock that includes a catch surface configured to engage with the step feature and resist further relative movement so that the body of the dilator is prevented from exiting the distal end of the expandable sheath. This interlocking engagement may allow the dilator to be used to extend and maintain tension on the expandable sheath during insertion into a patient, and then to be retracted from the expandable sheath by pulling the dilator in the opposite direction. The present technology also provides a dilator hub with a spring mechanism configured to achieve and maintain a desired tension on the expandable sheath and to prevent overextension of the expandable sheath when the dilator is being inserted into the expandable sheath.Type: GrantFiled: April 6, 2023Date of Patent: April 2, 2024Assignee: Abiomed, Inc.Inventors: Christopher N. Korkuch, Robert Fishman, Michael Thomas Finnegan, Charles DeLorenzo, Andrew Gentile, Anne Gabrielle McLoughlin, Robert Swierczek, Matthew D'Agostino, Jonathan Barry
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Publication number: 20170115241Abstract: A method and system for performing material identification and 2D scanning of a room temperature sample using a TES detector.Type: ApplicationFiled: October 21, 2016Publication date: April 27, 2017Inventors: Christopher G. Tully, Charles Gentile
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Patent number: 9318228Abstract: A method and apparatus for producing Mo-99 from Mo-100 for the use of the produced Mo-99 in a Tc-99m generator without the use of uranium is presented. Both the method and apparatus employ high energy gamma rays for the transformation of Mo-100 to Mo-99. The high energy gamma rays are produced by exposing a metal target to a moderated neutron output of between 6 MeV and 14 MeV. The resulting Mo-99 spontaneously decays into Tc-99m and can therefore be used in a Tc-99m generator.Type: GrantFiled: April 26, 2012Date of Patent: April 19, 2016Inventors: Charles A. Gentile, Adam B. Cohen, George Ascione
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Publication number: 20120275557Abstract: A method and apparatus for producing Mo-99 from Mo-100 for the use of the produced Mo-99 in a Tc-99m generator without the use of uranium is presented. Both the method and apparatus employ high energy gamma rays for the transformation of Mo-100 to Mo-99. The high energy gamma rays are produced by exposing a metal target to a moderated neutron output of between 6 MeV and 14 MeV. The resulting Mo-99 spontaneously decays into Tc-99m and can therefore be used in a Tc-99m generator.Type: ApplicationFiled: April 26, 2012Publication date: November 1, 2012Applicant: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Charles A. Gentile, Adam B. Cohen, George Ascione
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Publication number: 20110258151Abstract: A system for identifying radionuclide emissions is described. The system includes at least one processor for processing output signals from a radionuclide detecting device, at least one training algorithm run by the at least one processor for analyzing data derived from at least one set of known sample data from the output signals, at least one classification algorithm derived from the training algorithm for classifying unknown sample data, wherein the at least one training algorithm analyzes the at least one sample data set to derive at least one rule used by said classification algorithm for identifying at least one radionuclide emission detected by the detecting device.Type: ApplicationFiled: January 21, 2011Publication date: October 20, 2011Inventors: Charles A. Gentile, Jason Perry, Stephen W. Langish, Kenneth Silber, William M. Davis, Dana Mastrovito
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Patent number: 7877340Abstract: A system for identifying radionuclide emissions is described. The system includes at least one processor for processing output signals from a radionuclide detecting device, at least one training algorithm run by the at least one processor for analyzing data derived from at least one set of known sample data from the output signals, at least one classification algorithm derived from the training algorithm for classifying unknown sample data, wherein the at least one training algorithm analyzes the at least one sample data set to derive at least one rule used by said classification algorithm for identifying at least one radionuclide emission detected by the detecting device.Type: GrantFiled: April 16, 2010Date of Patent: January 25, 2011Assignee: Princeton UniversityInventors: Charles A. Gentile, Jason Perry, Stephen W. Langish, Kenneth Silber, William M. Davis, Dana Mastrovito
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Publication number: 20100280980Abstract: A system for identifying radionuclide emissions is described. The system includes at least one processor for processing output signals from a radionuclide detecting device, at least one training algorithm run by the at least one processor for analyzing data derived from at least one set of known sample data from the output signals, at least one classification algorithm derived from the training algorithm for classifying unknown sample data, wherein the at least one training algorithm analyzes the at least one sample data set to derive at least one rule used by said classification algorithm for identifying at least one radionuclide emission detected by the detecting device.Type: ApplicationFiled: April 16, 2010Publication date: November 4, 2010Inventors: Charles A. Gentile, Jason Perry, Stephen W. Langish, Kenneth Silber, William M. Davis, Dana Mastrovito
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Patent number: 7711661Abstract: A system for identifying radionuclide emissions is described. The system includes at least one processor for processing output signals from a radionuclide detecting device, at least one training algorithm run by the at least one processor for analyzing data derived from at least one set of known sample data from the output signals, at least one classification algorithm derived from the training algorithm for classifying unknown sample data, wherein the at least one training algorithm analyzes the at least one sample data set to derive at least one rule used by said classification algorithm for identifying at least one radionuclide emission detected by the detecting device.Type: GrantFiled: May 2, 2007Date of Patent: May 4, 2010Assignee: The Trustees of Princeton UniversityInventors: Charles A. Gentile, Jason Perry, Stephen W. Langish, Kenneth Silber, William M. Davis, Dana Mastrovito
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Publication number: 20080061994Abstract: A detector for detecting the presence of suspect radionuclides in a target is disclosed. The detector includes a first detection channel for a first detecting neutron emissions in the target and for providing a first output in accordance with the first detecting, a second detection channel for a second detecting x-ray emissions in the target and for providing a second output in accordance with the second detecting, a third detection channel for a third detecting and an identifying of gamma emissions in the target and for providing a third output in accordance with the third detecting and identifying, a signal manipulation electrically coupled to each of the first, second, and third detection channels, the signal manipulation for receiving the first, second and third outputs and for processing those outputs, and at least one processor electrically coupled to the signal manipulation.Type: ApplicationFiled: May 24, 2007Publication date: March 13, 2008Inventors: Charles Gentile, Andrew Carpe, Stephen Langish
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Publication number: 20070294059Abstract: A system for identifying radionuclide emissions is described. The system includes at least one processor for processing output signals from a radionuclide detecting device, at least one training algorithm run by the at least one processor for analyzing data derived from at least one set of known sample data from the output signals, at least one classification algorithm derived from the training algorithm for classifying unknown sample data, wherein the at least one training algorithm analyzes the at least one sample data set to derive at least one rule used by said classification algorithm for identifying at least one radionuclide emission detected by the detecting device.Type: ApplicationFiled: May 2, 2007Publication date: December 20, 2007Inventors: Charles Gentile, Jason Perry, Stephen Langish, Kenneth Silber, William Davis, Dana Mastrovito
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Publication number: 20070278415Abstract: The present invention is directed toward an apparatus and methods for detection and identification of target radionuclides and threatening radionuclides that may be present in a sample volume. One aspect of the invention discloses a digital computational apparatus that determines similarity or identity to a target radionuclide or a threatening radionuclide. In another aspect, the invention discloses a high throughput apparatus for detection of a target radionuclide in a sample volume, or for identifying a target radionuclide present in a sample volume, or both, that includes a detecting means, an analyzing means, and an identifying means. In a further aspect the invention discloses a high throughput apparatus for communicating the presence of a target radionuclide in a sample volume, the identity of a target radionuclide in a sample volume, or both to appropriate personnel.Type: ApplicationFiled: March 14, 2007Publication date: December 6, 2007Inventors: Charles Gentile, Andrew Carpe, Stephen Langish
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Publication number: 20070170368Abstract: The present invention is directed toward an apparatus and methods for detection and identification of target radionuclides and threatening radionuclides that may be present in a sample volume. One aspect of the invention discloses a digital computational apparatus that determines similarity or identity to a target radionuclide or a threatening radionuclide. In another aspect, the invention discloses a high throughput apparatus for detection of a target radionuclide in a sample volume, or for identifying a target radionuclide present in a sample volume, or both, that includes a detecting means, an analyzing means, and an identifying means. In a further aspect the invention discloses a high throughput apparatus for communicating the presence of a target radionuclide in a sample volume, the identity of a target radionuclide in a sample volume, or both to appropriate personnel.Type: ApplicationFiled: January 31, 2006Publication date: July 26, 2007Inventors: Charles Gentile, Andrew Carpe, Stephen Langish
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Patent number: 7244948Abstract: The present invention is directed toward an apparatus and methods for detection and identification of target radionuclides and threatening radionuclides that may be present in a sample volume. One aspect of the invention provides a digital computational apparatus that determines similarity or identity to a target radionuclide or a threatening radionuclide. In another aspect, the invention provides a high throughput apparatus for detection of a target radionuclide in a sample volume, or for identifying a target radionuclide present in a sample volume. In a further aspect the invention provides a high throughput apparatus for communicating the presence of a target radionuclide in a sample volume, the identity of a target radionuclide in a sample volume, or both to appropriate personnel.Type: GrantFiled: January 31, 2006Date of Patent: July 17, 2007Assignee: Princeton UniversityInventors: Charles A. Gentile, Andrew F. Carpe, Stephen W. Langish
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Patent number: 6994831Abstract: The Oxidative Tritium Decontamination System, OTDS, provides a method and apparatus for reduction of tritium surface contamination on various items. The OTDS employs ozone gas as oxidizing agent to convert elemental tritium to tritium oxide. Tritium oxide vapor and excess ozone gas is purged from the OTDS, for discharge to atmosphere or transport to further process. An effluent stream is subjected to a catalytic process for the decomposition of excess ozone to diatomic oxygen. One of two configurations of the OTDS is employed: dynamic apparatus equipped with agitation mechanism and large volumetric capacity for decontamination of light items, or static apparatus equipped with pressurization and evacuation capability for decontamination of heavier, delicate, and/or valuable items.Type: GrantFiled: October 23, 2002Date of Patent: February 7, 2006Assignee: The United States of America as represented by the United States Department of EnergyInventors: Charles A. Gentile, Gregory L. Guttadora, John J. Parker
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Publication number: 20050205799Abstract: A detector for detecting the presence of suspect radionuclides in a target is disclosed. The detector includes a first detection channel for a first detecting neutron emissions in the target and for providing a first output in accordance with the first detecting, a second detection channel for a second detecting x-ray emissions in the target and for providing a second output in accordance with the second detecting, a third detection channel for a third detecting and an identifying of gamma emissions in the target and for providing a third output in accordance with the third detecting and identifying, a signal manipulation electrically coupled to each of the first, second, and third detection channels, the signal manipulation for receiving the first, second and third outputs and for processing those outputs, and at least one processor electrically coupled to the signal manipulation.Type: ApplicationFiled: December 20, 2004Publication date: September 22, 2005Inventors: Charles Gentile, Lewis Meixler, Stephen Langish
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Publication number: 20040240509Abstract: The present invention is directed toward a window or foil that transmits incident radiation with high efficiency and that is coupled to a cooling means to dissipate heat from radiation losses occurring within the window. In one aspect the invention provides an energy-transmitting system that includes a nonmetallic window and means for cooling the window. In a second aspect the invention provides a laser assembly including a laser cavity enclosed by a wall that has one or more surfaces, wherein at least one surface includes an actively cooled window of the invention. In various embodiments of both the energy-transmitting system and the laser assembly the window includes a dielectric material, or a semiconducting material such as silicon. In addition a corrosion-resistant coating may be deposited on at least one surface of the window.Type: ApplicationFiled: May 10, 2004Publication date: December 2, 2004Applicant: Princeton UniversityInventors: Robert Parsells, Charles Gentile
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Publication number: 20040178339Abstract: The present invention is directed toward an apparatus and methods for detection and identification of target radionuclides and threatening radionuclides that may be present in a sample volume. One aspect of the invention discloses a digital computational apparatus that determines similarity or identity to a target radionuclide or a threatening radionuclide. In another aspect, the invention discloses a high throughput apparatus for detection of a target radionuclide in a sample volume, or for identifying a target radionuclide present in a sample volume, or both, that includes a detecting means, an analyzing means, and an identifying means. In a further aspect the invention discloses a high throughput apparatus for communicating the presence of a target radionuclide in a sample volume, the identity of a target radionuclide in a sample volume, or both to appropriate personnel.Type: ApplicationFiled: March 6, 2003Publication date: September 16, 2004Applicant: The Trustees of Princeton UniversityInventors: Charles Gentile, George Ascione, Andrew Carpe, Stephen Langish, John Parker