Abstract: The smart canister systems disclosed herein enables missile population to increase while minimizing the need for additional interface hardware. Particularly, multiplexing and demultiplexing functions and conversion flexibility enable the system to be adaptable to different types of missile characteristics and hardware. A redundant, bi-directional bus architecture with a distributed and dynamically reconfigurable control as well as enhanced built-in-test, fault monitoring and display capability enable the smart canister systems to provide a faster response time and higher launcher availability in a multifarious missile environment.

Abstract: cDNA clones containing the entire genome of Japanese encephalitis virus (JEV) were used to produce infectious, recombinant JEV particles with diverse virulence properties. Certain viruses retained the immunogenicity of JEV, but lacked the ability to cause encephalitis. The mutation associated with this loss of neurovirulence was localized to a nucleotide substitution in the codon encoding the 138th amino acid of the envelop protein, resulting in a mutation of an acidic amino acid to a basic amino acid. Attenuated viruses containing this mutation form the basis of a greatly improved, molecularly defined vaccine for the prevention of Japanese encephalitis in humans.