Patents by Inventor Charles H. Phoebe, JR.
Charles H. Phoebe, JR. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11965863Abstract: A liquid chromatography system includes a solvent delivery system, a sample manager including a sample delivery system in fluidic communication with the solvent delivery system, the sample delivery system configured to inject a sample from a sample-vial into a chromatographic flow stream, a liquid chromatography column located downstream from the sample delivery system, and a detector located downstream from the liquid chromatography column. The sample delivery system further includes a first needle drive including a first sample needle configured to extract the sample from the sample-vial and deliver the sample to the liquid chromatography column, and a first syringe in communication with the first sample needle configured to meter extraction of the sample from the sample-vial. The sample manager further includes a sample automation system that includes a second needle drive including a second sample needle configured to add a volume of reagent to the sample-vial.Type: GrantFiled: November 29, 2022Date of Patent: April 23, 2024Assignee: Waters Technologies CorporationInventors: Sylvain Gilles Cormier, Joseph D. Antocci, Francis Patrick Tracey, Charles H. Phoebe, Jr.
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Publication number: 20230094740Abstract: A liquid chromatography system includes a solvent delivery system, a sample manager including a sample delivery system in fluidic communication with the solvent delivery system, the sample delivery system configured to inject a sample from a sample-vial into a chromatographic flow stream, a liquid chromatography column located downstream from the sample delivery system, and a detector located downstream from the liquid chromatography column. The sample delivery system further includes a first needle drive including a first sample needle configured to extract the sample from the sample-vial and deliver the sample to the liquid chromatography column, and a first syringe in communication with the first sample needle configured to meter extraction of the sample from the sample-vial. The sample manager further includes a sample automation system that includes a second needle drive including a second sample needle configured to add a volume of reagent to the sample-vial.Type: ApplicationFiled: November 29, 2022Publication date: March 30, 2023Inventors: Sylvain Gilles Cormier, Joseph D. Antocci, Francis Patrick Tracey, Charles H. Phoebe, JR.
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Patent number: 11573211Abstract: A liquid chromatography system includes a solvent delivery system, a sample manager including a sample delivery system in fluidic communication with the solvent delivery system, the sample delivery system configured to inject a sample from a sample-vial into a chromatographic flow stream, a liquid chromatography column located downstream from the sample delivery system, and a detector located downstream from the liquid chromatography column. The sample delivery system further includes a first needle drive including a first sample needle configured to extract the sample from the sample-vial and deliver the sample to the liquid chromatography column, and a first syringe in communication with the first sample needle configured to meter extraction of the sample from the sample-vial. The sample manager further includes a sample automation system that includes a second needle drive including a second sample needle configured to add a volume of reagent to the sample-vial.Type: GrantFiled: March 23, 2021Date of Patent: February 7, 2023Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Sylvain Gilles Cormier, Joseph D. Antocci, Francis Patrick Tracey, Charles H. Phoebe, Jr.
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Publication number: 20220260532Abstract: Described are an interface module for two-dimensional chromatography and a method of performing a chromatographic separation that may use the interface module. The interface module includes a valve module, a collection needle, a modifier module and a sample storage element. The valve module has a first port configured to receive an eluent from a first chromatography system, a second port configured to provide a fraction obtained from the eluent, a third port and a fourth port. The collection needle and the modifier module are in fluidic communication with the valve module at the third and fourth ports, respectively. The modifier module includes a source of a modifier solvent. The sample storage element is in fluidic communication with the valve module and is configured to receive a volume of the fraction for injection as a sample into a second chromatography system.Type: ApplicationFiled: April 29, 2022Publication date: August 18, 2022Inventors: Sylvain Gilles Cormier, Charles H. Phoebe, JR.
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Patent number: 11360056Abstract: Described are an interface module for two-dimensional chromatography and a method of performing a chromatographic separation that may use the interface module. The interface module includes a valve module, a collection needle, a modifier module and a sample storage element. The valve module has a first port configured to receive an eluent from a first chromatography system, a second port configured to provide a fraction obtained from the eluent, a third port and a fourth port. The collection needle and the modifier module are in fluidic communication with the valve module at the third and fourth ports, respectively. The modifier module includes a source of a modifier solvent. The sample storage element is in fluidic communication with the valve module and is configured to receive a volume of the fraction for injection as a sample into a second chromatography system.Type: GrantFiled: August 30, 2019Date of Patent: June 14, 2022Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Sylvain Gilles Cormier, Charles H. Phoebe, Jr.
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Publication number: 20210302395Abstract: A liquid chromatography system includes a solvent delivery system, a sample manager including a sample delivery system in fluidic communication with the solvent delivery system, the sample delivery system configured to inject a sample from a sample-vial into a chromatographic flow stream, a liquid chromatography column located downstream from the sample delivery system, and a detector located downstream from the liquid chromatography column. The sample delivery system further includes a first needle drive including a first sample needle configured to extract the sample from the sample-vial and deliver the sample to the liquid chromatography column, and a first syringe in communication with the first sample needle configured to meter extraction of the sample from the sample-vial. The sample manager further includes a sample automation system that includes a second needle drive including a second sample needle configured to add a volume of reagent to the sample-vial.Type: ApplicationFiled: March 23, 2021Publication date: September 30, 2021Inventors: Sylvain Gilles Cormier, Joseph D. Antocci, Francis Patrick Tracey, Charles H. Phoebe, JR.
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Patent number: 11079360Abstract: Methods of chromatographic detection are provided that include the step of providing a chromatography instrument without an autosampler, an external device, a pressurized sample injection device and a chromatographic data system. The chromatographic instrument has a sample valve, a column manager and a solvent manager. The present methods further include the steps: injecting sample into the sample valve with a pressurized sample injection device; transmitting a signal from the chromatographic data system to the external device, receiving the signal by the external device, producing an event output with the external device, discharging solvent from the solvent manager into the sample valve, and discharging sample into the column for chromatographic detection.Type: GrantFiled: September 24, 2018Date of Patent: August 3, 2021Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Aaron D. Phoebe, Sylvain G. Cormier, Charles H. Phoebe, Jr.
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Publication number: 20200072800Abstract: Described are an interface module for two-dimensional chromatography and a method of performing a chromatographic separation that may use the interface module. The interface module includes a valve module, a collection needle, a modifier module and a sample storage element. The valve module has a first port configured to receive an eluent from a first chromatography system, a second port configured to provide a fraction obtained from the eluent, a third port and a fourth port. The collection needle and the modifier module are in fluidic communication with the valve module at the third and fourth ports, respectively. The modifier module includes a source of a modifier solvent. The sample storage element is in fluidic communication with the valve module and is configured to receive a volume of the fraction for injection as a sample into a second chromatography system.Type: ApplicationFiled: August 30, 2019Publication date: March 5, 2020Inventors: Sylvain Gilles Cormier, Charles H. Phoebe, JR.
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Publication number: 20200064313Abstract: Described are stator arrays for multi-valve systems used in different chromatographic applications. Also described is a mounting assembly for a multi-valve system that includes the stator array. Each stator array has a stator body having a first stator surface and a second stator surface. Each stator surface has a plurality of stator ports and is configured to engage a rotor surface of a rotary valve actuator. A fluid channel inside the stator body couples one of the stator ports of the first stator surface to one of the stator ports of the second stator surface. The fluid channel may be a microfluidic channel. A solid-state diffusion bonding process in which two or more parallel layers of material are joined together may be used to fabricate the stator body. Complex fluid channel networks may be formed using many fluid channels formed in multiple layers within the stator body.Type: ApplicationFiled: August 20, 2019Publication date: February 27, 2020Inventors: Sylvain Gilles Cormier, Charles H. Phoebe, Jr., Jason F. Hill, James P. Murphy, III
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Publication number: 20190366325Abstract: Described are systems and methods for online sample management. An online sample manager for a liquid chromatography system may include a process valve. The process valve may include a sample drawing position permitting fluidic passage between a process line and a sample syringe. The process valve may further include a storage position permitting fluidic passage between the sample syringe and at least one of a sample storage vessel and a wash component.Type: ApplicationFiled: May 28, 2019Publication date: December 5, 2019Inventors: Sylvain Gilles Cormier, Charles H. Phoebe, JR.
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Patent number: 10488373Abstract: Automated sampling and reaction systems and methods of using the same are provided. The automated sampling and reaction system has a microreactor in fluidic communication with an external sampling valve. The external sampling valve is connected to a priming valve and can be configured to draw sample from a reactor or a reactor stream. The microreactor is connected to a reagent valve and an injection valve. The reagent valve can be configured to draw reagent from a reagent reservoir and discharge reagent to the microreactor to react with sample. The priming valve can be configured to draw wash from a wash reservoir and discharge wash to the external sampling valve to move sample from the external sampling valve to the microreactor. The injection valve is in fluidic communication with a column or detector and discharges the secondary sample into a solvent composition stream.Type: GrantFiled: December 21, 2017Date of Patent: November 26, 2019Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Hillary B. Hewitson, Sylvain G. Cormier, Charles H. Phoebe, Jr., Aaron D. Phoebe
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Publication number: 20190101513Abstract: Methods of chromatographic detection are provided that include the step of providing a chromatography instrument without an autosampler, an external device, a pressurized sample injection device and a chromatographic data system. The chromatographic instrument has a sample valve, a column manager and a solvent manager. The present methods further include the steps: injecting sample into the sample valve with a pressurized sample injection device; transmitting a signal from the chromatographic data system to the external device, receiving the signal by the external device, producing an event output with the external device, discharging solvent from the solvent manager into the sample valve, and discharging sample into the column for chromatographic detection.Type: ApplicationFiled: September 24, 2018Publication date: April 4, 2019Inventors: Aaron D. Phoebe, Sylvain G. Cormier, Charles H. Phoebe, JR.
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Publication number: 20190092800Abstract: The present invention provides a novel, simple and reliable method for the separation of carbohydrate tautomers. The method comprises steps of chromatographically separating a sample using a chromatographic device. The method can be used to separate mono- and disaccharides tautomeric species including arabinose, xylose, fructose, mannose, galactose, glucose, lactose, and maltose.Type: ApplicationFiled: September 26, 2018Publication date: March 28, 2019Inventors: Charles H. Phoebe, Jr., Aaron D. Phoebe
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Publication number: 20180149625Abstract: Automated sampling and reaction systems and methods of using the same are provided. The automated sampling and reaction system has a microreactor in fluidic communication with an external sampling valve. The external sampling valve is connected to a priming valve and can be configured to draw sample from a reactor or a reactor stream. The microreactor is connected to a reagent valve and an injection valve. The reagent valve can be configured to draw reagent from a reagent reservoir and discharge reagent to the microreactor to react with sample. The priming valve can be configured to draw wash from a wash reservoir and discharge wash to the external sampling valve to move sample from the external sampling valve to the microreactor. The injection valve is in fluidic communication with a column or detector and discharges the secondary sample into a solvent composition stream.Type: ApplicationFiled: December 21, 2017Publication date: May 31, 2018Inventors: Hillary B. Hewitson, Sylvain G. Cormier, Charles H. Phoebe, JR., Aaron D. Phoebe
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Patent number: 9857339Abstract: Automated sampling and reaction systems and methods of using the same are provided. The automated sampling and reaction system has a microreactor in fluidic communication with an external sampling valve. The external sampling valve is connected to a priming valve and can be configured to draw sample from a reactor or a reactor stream. The microreactor is connected to a reagent valve and an injection valve. The reagent valve can be configured to draw reagent from a reagent reservoir and discharge reagent to the microreactor to react with sample. The priming valve can be configured to draw wash from a wash reservoir and discharge wash to the external sampling valve to move sample from the external sampling valve to the microreactor. The injection valve is in fluidic communication with a column or detector and discharges the secondary sample into a solvent composition stream.Type: GrantFiled: December 22, 2015Date of Patent: January 2, 2018Assignee: WATERS TECHNOLOGIES CORPORATIONInventors: Hillary B Hewitson, Sylvain G Cormier, Charles H. Phoebe, Jr., Aaron D Phoebe
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Publication number: 20160195564Abstract: Automated sampling and reaction systems and methods of using the same are provided. The automated sampling and reaction system has a microreactor in fluidic communication with an external sampling valve. The external sampling valve is connected to a priming valve and can be configured to draw sample from a reactor or a reactor stream. The microreactor is connected to a reagent valve and an injection valve. The reagent valve can be configured to draw reagent from a reagent reservoir and discharge reagent to the microreactor to react with sample. The priming valve can be configured to draw wash from a wash reservoir and discharge wash to the external sampling valve to move sample from the external sampling valve to the microreactor. The injection valve is in fluidic communication with a column or detector and discharges the secondary sample into a solvent composition stream.Type: ApplicationFiled: December 22, 2015Publication date: July 7, 2016Applicant: Waters Technologies CorporationInventors: Hillary B. Hewitson, Sylvain G. Cormier, Charles H. Phoebe, JR., Aaron D. Phoebe
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Patent number: 9024635Abstract: A device for performing chromatographic separations and nuclear magnetic resonance analysis has trapping means for holding a separated sample and to form a held separated sample and placing said held separated sample in said nuclear magnetic resonance assembly. One preferred trapping means forms a held separated sample and a passed separated sample. The passed separated sample is discharged from the device. Preferred trapping means comprise a trapping column or a separated sample loop.Type: GrantFiled: October 4, 2011Date of Patent: May 5, 2015Assignee: Waters Technologies CorporationInventors: Theodore A. Dourdeville, Charles H. Phoebe, Jr.
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Publication number: 20120262178Abstract: A device for performing chromatographic separations and nuclear magnetic resonance analysis has trapping means for holding a separated sample and to form a held separated sample and placing said held separated sample in said nuclear magnetic resonance assembly. One preferred trapping means forms a held separated sample and a passed separated sample. The passed separated sample is discharged from the device. Preferred trapping means comprise a trapping column or a separated sample loop.Type: ApplicationFiled: October 4, 2011Publication date: October 18, 2012Applicant: WATERS TECHNOLOGIES CORPORATIONInventors: Theodore A. Dourdeville, Charles H. Phoebe, JR.