Patents by Inventor Charles H. Spilman

Charles H. Spilman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrazoloazepino substituted oximes useful as anti-atherosclerosis and anti-hypercholesterolemic agents
    Patent number: 5597816
    Abstract: Pyrazoloazepino-substituted oximes, having the formula ##STR1## wherein R is ##STR2## where R.sup.5 is --(CH.sub.2).sub.c -- and c is 3-6 are disclosed. These compounds are useful for the treatment of atherosclerosis and hypercholesterolemia.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 28, 1997
    Assignee: The Upjohn Company
    Inventors: Scott D. Larsen, Charles H. Spilman
  • Pyridino substituted oximes useful as anti-atherosclerosis and anti-hypercholesterolemic agents
    Patent number: 5565468
    Abstract: Imidazopyridino- and pyrazolopyridino- substituted oximes are disclosed having the formulas ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and a are as described in the claims. for the treatment of atherosclerosis and hypercholesterolemia.
    Type: Grant
    Filed: September 27, 1994
    Date of Patent: October 15, 1996
    Assignee: The Upjohn Company
    Inventors: Scott D. Larsen, Charles H. Spilman
  • Pyrrolidino-substituted oximes useful as anti-atherosclerosis and anti-hypercholesterolemic agents
    Patent number: 5523318
    Abstract: Pyrrolidinopyrazole-substituted oximes having the formula ##STR1## are disclosed wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and a are as described in the claims for the treatment of atherosclerosis and hypercholesterolemia.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 4, 1996
    Assignee: The Upjohn Company
    Inventors: Scott D. Larsen, Charles H. Spilman
  • Fine-milled colestipol hydrochloride
    Patent number: 5520932
    Abstract: The present invention provides a novel fine milled form of a known pharmaceutical composition, colestipol hydrochloride. This fine milled form of colestipol hydrochloride yields pharmaceutically elegant dosage forms exhibiting increased potency, including non-gritty oral powders and high dose oral tablets (e.g., 1000 mg tablets). Conventional colestipol hydrochloride was heretofore available in spherical granules which produced less elegant (gritty) oral suspensions and oral tablets with substantially lower doses of drug (e.g., ca 500 mg).
    Type: Grant
    Filed: August 3, 1994
    Date of Patent: May 28, 1996
    Assignee: The Upjohn Company
    Inventors: Vincent E. McCurdy, Charles H. Spilman
  • Lipophilic polyamines useful for treating hypercholesterolemia
    Patent number: 5192798
    Abstract: This invention relates to novel lipophilic polyamines of formula I, the method of using these compounds to treat hypercholesterolemia, and intermediates thereto.Z.sub.1 --(CH.sub.2).sub.n --Y.sub.1 --X.sub.1 --R.sub.
    Type: Grant
    Filed: August 16, 1990
    Date of Patent: March 9, 1993
    Assignee: The Upjohn Company
    Inventors: James W. Aiken, Charles H. Spilman, Edward W. Thomas