Patents by Inventor Charles H. Vite

Charles H. Vite has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12359181
    Abstract: This invention relates to polynucleotides comprising optimized GALC open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a GALC gene or aberrant activity of a GALC gene product in the subject, such as Krabbe disease (i.e., globoid cell leukodystrophy (GLD)).
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: July 15, 2025
    Assignees: The University of North Carolina at Chapel Hill, The Trustees of the University of Pennsylvania
    Inventors: Steven James Gray, Erik Lykken, Charles H. Vite, Allison Bradbury
  • Publication number: 20210395712
    Abstract: This invention relates to polynucleotides comprising optimized GALC open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a GALC gene or aberrant activity of a GALC gene product in the subject, such as Krabbe disease (i.e., globoid cell leukodystrophy (GLD)).
    Type: Application
    Filed: December 20, 2019
    Publication date: December 23, 2021
    Inventors: Steven James Gray, Erik Lykken, Charles H. Vite, Allison Bradbury