Abstract: Described herein are drug delivery systems for delivering biologically active agents comprising primary or secondary amines, or a ring nitrogen atom of an azaheteroaryl ring, pharmaceutically acceptable salts thereof, drug delivery reagents related thereto, pharmaceutical compositions comprising the drug delivery systems, and the use of the drug delivery systems as sustained release therapeutics.

Abstract: Described herein are drug delivery systems for delivering biologically active agents comprising primary or secondary amines, or a ring nitrogen atom of an azaheteroaryl ring, pharmaceutically acceptable salts thereof, drug delivery reagents related thereto, pharmaceutical compositions comprising the drug delivery systems, and the use of the drug delivery systems as sustained release therapeutics.

Abstract: A sealable container assembly with an internal, removable panel and a spout. The container assembly has a simplified construction that includes a container, a panel with a spout that is removably positionable inside an interior volume of the container and a lid that is removably attachable to the container to seal the interior volume of the container with the panel and spout positioned in the interior volume of the container.

Abstract: The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.

Abstract: Described herein are drug delivery systems for delivering biologically active agents comprising primary or secondary amines, or a ring nitrogen atom of an azaheteroaryl ring, pharmaceutically acceptable salts thereof, drug delivery reagents related thereto, pharmaceutical compositions comprising the drug delivery systems, and the use of the drug delivery systems as sustained release therapeutics.

Abstract: The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.

Abstract: The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.

Abstract: An antenna is disclosed. The antenna can include an aerodynamic surface and an antenna component comprising a structure configured to extend from the aerodynamic surface. The structure and at least a portion of the aerodynamic surface can form an antenna, such as a half double-ridge horn antenna or a half Vivaldi antenna. In one aspect, the structure can be configured to support a pod, thus integrating the antenna with a mechanical mounting structure for the pod.

Abstract: Provided is a modular construction kit adapted to construct a raised temporary platform, the modular construction kit comprising one or more floor elements (1), wherein the floor element (1) comprises a monocoque structure (6) forming a floor section (21) and a flange section (3), wherein the flange section (3) is adapted to strengthen the floor element (1) and is adapted to be attached to a further floor element (1), wherein the floor elements (1) are load bearing and cooperate together to bear the load of the platform so as to form a self-supporting floor, without the requirement for a supporting floor frame.

Abstract: The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.

Abstract: The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.

Abstract: A feed-forward cancellation system includes a transmitting element and a receiving element. The transmitting element is in electrical communication with a transmitting line. The transmitting element is configured output a transmission signal to the transmitting line. The receiving element is in electrical communication with a receiving line. The receiving element is configured to process a response signal that is generated in response to the transmission signal and that is delivered to the receiving line. At least one antenna is configured to transmit the transmission signal, receive the response signal generated based on the transmission signal, and deliver the response signal to the receiving line. The feed-forward cancellation system further includes an electronic cancellation unit configured to generate a cancellation signal based on the transmission signal. The cancellation signal eliminates saturation from at least one of the response signal and the receiving line.

Abstract: A wideband radio frequency (RF) interference cancellation system includes an electronic channel canceller configured to split an electronic reference signal output from an electronic transmitting element into a plurality of band signals. At least one electronic band pass filter is configured to receive a respective band signal delivered to a respective channel. The wideband RF interference cancellation system further includes at least one electronic tunable cancellation element configured to tune the respective channel such that reflections are canceled before being input to receiving element.

Abstract: A wideband radio frequency (RF) interference cancellation system includes an electronic channel canceller configured to split an electronic reference signal output from an electronic transmitting element into a plurality of band signals. At least one electronic band pass filter is configured to receive a respective band signal delivered to a respective channel. The wideband RF interference cancellation system further includes at least one electronic tunable cancellation element configured to tune the respective channel such that reflections are canceled before being input to receiving element.

Abstract: A feed-forward cancellation system includes a transmitting element and a receiving element. The transmitting element is in electrical communication with a transmitting line. The transmitting element is configured output a transmission signal to the transmitting line. The receiving element is in electrical communication with a receiving line. The receiving element is configured to process a response signal that is generated in response to the transmission signal and that is delivered to the receiving line. At least one antenna is configured to transmit the transmission signal, receive the response signal generated based on the transmission signal, and deliver the response signal to the receiving line. The feed-forward cancellation system further includes an electronic cancellation unit configured to generate a cancellation signal based on the transmission signal. The cancellation signal eliminates saturation from at least one of the response signal and the receiving line.

Abstract: A miniature interrogator antenna assembly including: a housing; a first miniature horn antenna in the housing having a first aperture; a second miniature horn antenna in the housing having a second aperture. The first and second miniature horn antennas are arranged in a canted configuration and are joint at a front of the assembly to form combined apertures at the front of the assembly. The antenna assembly further includes: a splitter/combiner having a matching portion, where the matching portion is positioned in the housing in such a way that an apex of the matching portion points to the front of the assembly; a plurality of annular grooves formed around the combined apertures at the front of the assembly; a sum input port coupled to a first waveguide with an H-plane bend feeding the splitter/combiner; and a difference input port coupled to a second waveguide feeding the splitter/combiner directly.

Abstract: The present invention provides pyridin-oxadiazole/thiadiazole derivatives of Formula I wherein A is N or CR 4a; and (ii) or (iii) which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: The present invention provides pyridin-oxadiazole/thiadiazole derivatives of Formula I wherein A is N or CR 4a; and (ii) or (iii) which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: Provided is a modular construction kit adapted to construct a raised temporary platform, the modular construction kit comprising one or more floor elements, wherein the floor element comprises a monocoque structure forming a floor section and a flange section, wherein the flange section is adapted to strengthen the floor element and is adapted to be attached to a further element to form a self-supporting floor, without the requirement for a supporting floor frame.

Abstract: A method of preparing a diorganodihalosilane, the method comprising the following separate and consecutive steps: (i) treating a preformed metal silicide with a mixture comprising hydrogen gas and a silicon tetrahalide at a temperature from 300 to 1400° C. to form a treated metal silicide, wherein the preformed metal silicide comprises a metal selected from at least one of Ni, Pd, or Pt; and (ii) reacting the treated metal silicide with an organohalide according to the formula RX at a temperature from 250 to 700° C. to form a diorganodihalosilane, wherein R is C1-C10 hydrocarbyl and X is halo.