Abstract: A static mixing apparatus for mixing a fluid, preferably a liquid is provided. The mixer comprises a plurality of chambers in series, the first chamber of the series comprising a fluid inlet, and the final chamber of the series comprising a fluid outlet, each chamber except the final chamber including orifices defining a flow path from the fluid inlet and into each chamber in series and to the fluid outlet and the final chamber including a gas outlet located at the opposite end of the static mixing apparatus to the fluid inlet and fluid outlet.

Abstract: Apparatus for processing a liquid comprising a target substance, preferably a biomolecule, is provided.

Abstract: Apparatus for processing a liquid comprising a target substance, preferably a biomolecule, is provided.

Abstract: A method of concentration of a liquid comprising a biomolecule is provided. The method comprises passing the liquid through a tangential flow filtration device under pressure, wherein the pressure applied is varied between at least a higher pressure and a lower pressure. Preferably, the variation in pressure is delivered by the use of a variable flow-controller, such as a valve.

Abstract: A process for purifying a composition comprising water, a target substance, impurities and optionally cells, the process comprising the steps (A) and (B): (A) preparing a liquid feedstock by performing step (Ai) and/or (Aii) on the composition: (Ai) removing at least some of the cells from the composition; (Aii) concentrating the composition by removing water therefrom; and (B) passing the liquid feedstock through an apparatus comprising at least two processing units, each such unit producing a product stream containing purified target substance and optionally a waste stream comprising at least some of the impurities, wherein each unit comprises specified components (i) to (v). The units may be essentially the same except for a device they contain, leading to advantages in terms of simplicity, cost and ease of operation, lower risk of operator error, easier maintenance and lower inventory of spare parts.

Abstract: Apparatus for purifying a liquid comprising a target substance comprising at least two units arranged in series such that the feed stream of the second and any subsequent units comprises the product stream from a downstream unit, wherein each unit comprises specified components (i) to (vi), including a a switchable bypass assembly. Also claimed are the units and a flowpath assembly. The units may be essentially the same except for a device they contain, leading to advantages in terms of simplicity, cost and ease of operation, lower risk of operator error, easier maintenance and lower inventory of spare parts.

Abstract: Apparatus for in-line liquid exchanging a biomolecule-containing liquid is provided. The apparatus comprises a means for mixing at least two liquids comprising a multiple inlet flow-controller, the means for mixing also comprising an outlet in fluid connection with a tangential flow filtration device configured in single-pass mode.

Abstract: A process for purifying a liquid feedstock comprising a monoclonal antibody and impurities, the process comprising passing the liquid feedstock through an apparatus comprising at least two processing units, each such unit producing a product stream containing purified monoclonal antibody and optionally a waste stream comprising at least some of the impurities, wherein each unit comprises specified components (i) to (v) which include a multiple inlet flow-controller comprising two or more variable flow inlet valves for in situ production of a bioprocessing liquid by combining at least two liquids in a desired ratio. One of the units performs chromatography and another performs viral inactivation. The units may be essentially the same except for a device they contain, leading to advantages in terms of simplicity, cost and ease of operation, lower risk of operator error, easier maintenance and lower inventory of spare parts.

Abstract: A static mixing apparatus for mixing a fluid, preferably a liquid is provided. The mixer comprises a plurality of chambers (5, 8, 12, 15) in series, the first chamber (5) of the series comprising a fluid inlet (4), and the final chamber (15) of the series comprising a fluid outlet (16), each chamber other than the final chamber in the series being in fluid connection with a subsequent chamber, the fluid connection comprising a plurality of orifices (7, 10, 11, 14) dispersed along a direction of flow, the nearest point to the fluid inlet of each subsequent orifice to the inlet overlapping with the furthest point from the fluid inlet of the previous orifice, and being off-set along the direction of flow from the previous orifice.

Abstract: A method of concentration of a liquid comprising a biomolecule is provided. The method comprises passing the liquid through a tangential flow filtration device under pressure, wherein the pressure applied is varied between at least a higher pressure and a lower pressure. Preferably, the variation in pressure is delivered by the use of a variable flow-controller, such as a valve.

Abstract: A method of concentration of a liquid comprising a biomolecule is provided. The method comprises passing the liquid through a tangential flow filtration device under pressure, wherein the pressure applied is varied between at least a higher pressure and a lower pressure. Preferably, the variation in pressure is delivered by the use of a variable flow-controller, such as a valve.

Abstract: Apparatus for processing a liquid comprising a target substance, preferably a biomolecule, is provided.

Abstract: Apparatus for in-line liquid exchanging a biomolecule-containing liquid is provided. The apparatus comprises a means for mixing at least two liquids comprising a multiple inlet flow-controller, the means for mixing also comprising an outlet in fluid connection with a tangential flow filtration device configured in single-pass mode.

Abstract: Apparatus for in-line liquid exchanging a biomolecule-containing liquid is provided. The apparatus comprises a means (3) for mixing at least two liquids comprising a multiple inlet flow-controller (2), the means for mixing also comprising an outlet in fluid connection with a tangential flow filtration device (1) configured in single-pass mode.

Abstract: A method of concentration of a liquid comprising a biomolecule is provided. The method comprises passing the liquid through a tangential flow filtration device under pressure, wherein the pressure applied is varied between at least a higher pressure and a lower pressure. Preferably, the variation in pressure is delivered by the use of a variable flow-controller, such as a valve.

Abstract: Apparatus for in-line liquid exchanging a biomolecule-containing liquid is provided. The apparatus comprises a means (3) for mixing at least two liquids comprising a multiple inlet flow-controller (2), the means for mixing also comprising an outlet in fluid connection with a tangential flow filtration device (1) configured in single-pass mode.

Abstract: In one embodiment, a method includes storing code defining access control rules for an object, the code defining each of the access control rules as a set of operations that each returns (1) when resolved, a predetermined result, and (2) when not resolved, a not definitive result indicating that it should be skipped if it is not necessary for determining the access control rule; compiling the code; compiling and loading the code; receiving a query for the object; executing the code to evaluate the corresponding operations; determining, for each access control rule, a rule-result comprising a value representing a true or a false value; determining a final result based on the one or more rule-results of the one or more access control rules, the final result indicating an allow-result or a deny-result; and sending the object when the final result evaluates to an allow-result.

Abstract: In one embodiment, a method includes receiving a request for an object; retrieving one or more rules to evaluate whether to allow or deny access to the object, wherein a first rule is of an allow-type or a deny-type; evaluating the first rule by executing one or more of its operations, wherein when any of the executed operations of the first rule returns a result that is not definitive, if the first rule is of the allow-type, assigning a final result as an indication to skip evaluation of the rule, and if the rule is of the deny-type, assigning the final result to the first rule as an indication to deny access to the object; determining final results for the one or more rules; and based on the final results, allowing or denying access to the object.

Abstract: In one embodiment, a method includes receiving a request for an object; retrieving one or more rules to evaluate whether to allow or deny access to the object, wherein a first rule is of an allow-type or a deny-type; evaluating the first rule by executing one or more of its operations, wherein when any of the executed operations of the first rule returns a result that is not definitive, if the first rule is of the allow-type, assigning a final result as an indication to skip evaluation of the rule, and if the rule is of the deny-type, assigning the final result to the first rule as an indication to deny access to the object; determining final results for the one or more rules; and based on the final results, allowing or denying access to the object.

Abstract: Systems and methods for protecting the privacy of users by controlling access to the users' data. In particular, some embodiments provide for a higher-level declarative language for expressing privacy policies which can be verified using a computer-aided verification tool. The verification tool uses the expressed privacy policies along with language-level assumptions and assertions in the verification process. For example, high-level models of the privacy policies can be reduced to a simpler verification representation (e.g., a Boolean representation) based on a set of assertions. This verification representation can then be submitted to a constraint solver (e.g., Satisfiability Modulo Theories solver) for verification.