Abstract: A controlled release potassium chloride tablet is disclosed which is comprised of potassium chloride crystals having a mesh size of about 30 to about 50 mesh which are coated with a coating material comprised of ethylcellulose and hydroxypropylcellulose. The coated crystals form micro pellets which then can be compressed into tablets. The tablets disintegrate rapidly in an aqueous environment thus assuring a more uniform dissolution of the active component as compared with other types of controlled release potassium chloride dosage formulations. The distribution of the potassium chloride micro pellets over a wide surface area in the gastrointestinal mucosa aids in reducing the risk of gastrointestinal lesions. The formation of the coated micro pellets which disperse quickly upon contact with aqueous environment allow for the repeated chronic oral administration of a relatively large dose of potassium chloride (20 mEq).

Abstract: A sustained release oral dosage form is provided comprising a tablet core containing a pharmaceutically effective amount of quinidine. The tablet core is coated with a sustained release polymeric coating which contains about 5 to about 20 percent by weight polyethylene glycol component having a molecular weight of from about 500 to about 200, and from about 80 to 95 percent by weight polyvinylalcohol component. The polyvinylalcohol component comprises from about one to about ten parts by weight of a partially hydrolyzed polyvinylalcohol subcomponent having a degree of hydrolysis of from about 75 to about 92 percent and about one part by weight of a substantially completely hydrolyzed polyvinylalcohol subcomponent having a degree of hydrolysis in excess of 95%.