Abstract: According to some embodiments, a system for fractionally treating tissue includes: an electromagnetic radiation (EMR) source configured to generate an EMR beam having a transverse ring energy profile; an optic configured to converge the EMR beam to a focal region located within a tissue; and, a window assembly located down-beam from the optic configured to cool the tissue when placed in contact with an outer surface of the tissue.

Abstract: The present disclosure relates to compounds of Formula (Ia) and (Ib): or a pharmaceutically acceptable salt thereof, which are useful in the treatment of an HIV infection in heavily treatment-experienced patients with multidrug resistant HIV infection.

Abstract: Systems and methods are provided for the generation of synthetic repeatable data. In an illustrative implementation, an exemplary data environment comprises at least one computing application for the management, manipulation, and generation of data. The computing application operates on a predefined set of rules to generate a data set, having N elements, using a deterministic generator function which when executed always produces the same set of data. The seed is used to position the generator to a particular point in its sequence. To regenerate any particular entry in the data set, the generator, using the seed as an input, is executed and the desired data is re-generated. The illustrative implementation also contemplates that the generation of data may be parallelizable as each element is generated independently of any others.

Abstract: Systems and methods are provided for the generation of synthetic repeatable data. In an illustrative implementation, an exemplary data environment comprises at least one computing application for the management, manipulation, and generation of data. The computing application operates on a predefined set of rules to generate a data set, having N elements, using a deterministic generator function which when executed always produces the same set of data. The seed is used to position the generator to a particular point in its sequence. To regenerate any particular entry in the data set, the generator, using the seed as an input, is executed and the desired data is re-generated. The illustrative implementation also contemplates that the generation of data may be parallelizable as each element is generated independently of any others.

Abstract: A developer composition comprising (1) electroscopic toner particles (2) a friction-reducing material of a hardness less than said toner and having greater fricton-reducing characteristics than said toner material, and (3) a finely divided nonsmearable abrasive material of a hardness greater than said friction-reducing and toner materials. An imaging and development process utilizing the above-identified composition including the step of maintaining the buildup of friction-reducing material on an imaging surface in the submicron range without completely removing or preventing said buildup, by the combined action of a cleaning force wiping at least any residual developed image from at least a portion of said imaging surface.