Patents by Inventor Charles J. Link, Jr.

Charles J. Link, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Differential inactivation of nucleic acids by chemical modification
    Patent number: 5843459
    Abstract: Disclosed herein is the method for dramatically reducing cytotoxicity of viral vectors such as Herpes simplex viral while retaining gene expression. The method of the invention virtually eliminates the concern of possible recombination during virus propagation and contamination of wild-type virus and virus stock. The invention comprises use of photochemical crosslinking causing differential inactivation of viruses.
    Type: Grant
    Filed: January 19, 1996
    Date of Patent: December 1, 1998
    Assignee: Human Gene Therapy Research Institute
    Inventors: Suming Wang, Charles J. Link, Jr.
  • Herpes simplex virus amplicon mini-vector gene transfer system
    Patent number: 5830727
    Abstract: A novel HSV mini viral vector is disclosed. The vector comprises HSV and EBV genes which allow it to remain in episomal state, to have very high transfection and infection, and to tolerate up to 140 kb of foreign DNA. Techniques and genetic constructs for producing the vectors, for constructing the vectors and transfection and infection to recipient cells are disclosed.
    Type: Grant
    Filed: December 26, 1995
    Date of Patent: November 3, 1998
    Assignee: Human Gene Therapy Research Institute
    Inventors: Suming Wang, Charles J. Link, Jr.