Abstract: A multi-layer (multi-lamellar) coated nanoparticle is provided wherein the nanoparticle comprises a first coat comprising a positively charged polymer or a positively charged lipd bilayer and a second coat comprising an anionic bilayer and optionally one or more distinct cargo molecules, one or more distinct targeting moieties, or any combination thereof, as well as methods of making and using the nanoparticle.

Abstract: The present disclosure is directed to protocells or nanoparticles, which are optionally coated with a lipid bilayer, which can be used for targeting bone tissue for the delivery of bioactive agents useful in the treatment and/or diagnosis of bone cancer, often metastatic bone cancer which often occurs secondary to a primary cancer such as prostate cancer, breast cancer, lung cancer and ovarian cancer, among numerous others. These protocells or nanoparticles target bone cancer especially metastatic bone cancer with bioactive agents including anticancer agents and/or diagnostic agents for purposes of treating, diagnosing and/or monitoring the therapy of the bone cancer. Osteotropic protocells or nanoparticles, pharmaceutical compositions comprising a population of osteotropic protocells or nanoparticles and methods of diagnosing, treating and/or monitoring therapy of bone cancer are representative aspects.

Abstract: A luminaire includes a light source positioned at a first level within a luminaire housing. The luminaire also includes a trim component positioned at a second level of the luminaire housing different from the first level. The trim component extends into a room from a ceiling surface and includes an aperture antenna that receives wireless signals and transmits wireless signals. Further, the luminaire includes a communication module that communicates wirelessly with one or more devices remote from the luminaire by controlling excitation of the aperture antenna.

Abstract: A wireless controller system includes a cradle device and a wireless controller. The cradle device includes a power input that receives power from a power source, a first communication module that communicates wirelessly with one or more devices remote from the cradle device, and a first electrical interface that provides a charging power to the wireless controller. The wireless controller includes a display device that displays lighting system control features. The wireless controller also includes a second communication module that communicates wirelessly with the first communication module of the cradle device. Additionally, the wireless controller includes a microphone that receives a voice input to interact with at least one voice assistant, and a second electrical interface that generates a power link with the first electrical interface of the cradle device to receive the charging power from the cradle device.

Abstract: In one aspect, the disclosure provides mesoporous silica nanoparticles (MSNPs), monodisperse populations of MSNPs and related protocells which exhibit cell binding specificity. For example, MSNPs and protocells of the disclosure may be used to target specific delivery of therapeutic agents to CD19 or EGFR expressing cancer cells, or target specific delivery of therapeutic agents to other cell types. Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.

Abstract: A lighting system includes a first luminaire. The first luminaire includes a first light source that generates a first light output. The first luminaire also includes a first visual feedback response source that generates a first visual feedback response output. Additionally, the first luminaire includes a first speaker that generates a first audio output. Further, the lighting system includes a second luminaire. The second luminaire includes a second light source that generates a second light output and a second visual feedback response source that generates a second visual feedback response output. Furthermore, the second luminaire includes a second speaker that generates a second audio output. The second audio output is different from the first audio output such that the first speaker and the second speaker output different audio components of a multichannel audio protocol output.

Abstract: A mixing tee assembly suitable for phosphate acid attack reaction is described. The mixing tee assembly comprises an outer pipe having a mixing end and a tee end, wherein a tee structure is formed near the tee end to connect with additional piping; an inner pipe comprising a nozzle end connected to a nozzle and a open end; wherein the inner pipe is lined with a corrosion-resistant material on its inside surface; wherein when the inner pipe is assembled within the outer pipe, the nozzle extends beyond the mixing end of the outer pipe by at least ? of the inside diameter of the outer pipe.

Abstract: Disclosed are compositions and methods relating to prostate cancer. In particular, disclosed are bivalent targeting ligands that specifically bind prostate specific membrane antigen and gastrin-releasing peptide receptor. Bivalent binding agents disclosed herein can be used to image a tissue in a subject in need thereof and to diagnose prostate cancer in a subject in need thereof. Bivalent binding agents disclosed herein can be used to treat prostate cancer in a subject in need thereof.

Abstract: A luminaire includes a first light source positioned at a first level of a luminaire housing. The first light source generates a light output. The luminaire also includes a trim component positioned at a second level of the luminaire housing different from the first level, The trim component includes a visual feedback element that emits a visual feedback response. Further, the luminaire includes a control circuit positioned at the second level within the trim component. The control circuit controls operation of the visual feedback element.

Abstract: A luminaire includes a speaker positioned at a first depth within a luminaire housing and capable of generating an audio output from a speaker diaphragm. The luminaire also includes a light source that generates a light output. Further, the luminaire includes a light guide assembly positioned at a second depth within the luminaire housing different from the first depth. The light guide assembly includes an acoustically transparent area positioned along a sound path from the speaker diaphragm, and the light guide assembly extracts the light output from the light source and directs the light output away from the luminaire.

Abstract: The present disclosure is directed to methods of producing star-like mesoporous silica nanoparticles (SMSNPs) and protocells SMSNPs and their use for targeted drug delivery formulations and systems and for biomedical applications. Also provided are methods of producing monosized protocells from monodisperse SMSNPs and their use for targeted drug delivery formulations and systems and for biomedical applications.

Abstract: The present disclosure is directed to methods of producing lipid coated nanoparticles useful for biomedical applications, e.g., vaccines, adjuvants. The present disclosure is also directed in part to, e.g., multilamellar or unilamellar, protocell vaccines.

Abstract: Provided are polymer-aerogel composite coatings, devices and articles including polymer-aerogel composite coatings, and methods for preparing the polymer-aerogel composite. The exemplary article can include a surface, wherein the surface includes at least one region and a polymer-aerogel composite coating disposed over the at least one region, wherein the polymer-aerogel composite coating has a water contact angle of at least about 140° and a contact angle hysteresis of less than about 1°. The polymer-aerogel composite coating can include a polymer and an ultra high water content catalyzed polysilicate aerogel, the polysilicate aerogel including a three dimensional network of silica particles having surface functional groups derivatized with a silylating agent and a plurality of pores.

Abstract: A porous protocell is provided comprising one or more non-integrating vectors comprising nucleic acid encoding a non-nucleolytic fusion protein comprising a protein sequence that specifically binds a sequence in a double strand nucleic acid molecule linked to a protein sequence that is a transcriptional mediator, and optionally guide RNA or a vector for expression of guide RNA, and methods of using the protocells.

Abstract: Disclosed are compositions and methods relating to prostate cancer. In particular, disclosed are bivalent targeting ligands that specifically bind prostate specific membrane antigen and gastrin-releasing peptide receptor. Bivalent binding agents disclosed herein can be used to image a tissue in a subject in need thereof and to diagnose prostate cancer in a subject in need thereof. Bivalent binding agents disclosed herein can be used to treat prostate cancer in a subject in need thereof.

Abstract: A downlight fixture includes an optic housing, a light-emitting diode (LED) array, and a lens-less reflector. The LED array emits directional light rays in a downward direction towards an illuminated target. The reflector is mounted within the optic housing and adjacent to the LED array. The reflector has a hyperbolic wall continuously extending between a narrow neck and a wide bell. The light rays are spread into a light beam within the reflector upon making contact solely with the hyperbolic wall.

Abstract: A luminaire includes a first light source positioned at a first level of a luminaire housing. The first light source generates a light output. The luminaire also includes a trim component positioned at a second level of the luminaire housing different from the first level, The trim component includes a visual feedback element that emits a visual feedback response. Further, the luminaire includes a control circuit positioned at the second level within the trim component. The control circuit controls operation of the visual feedback element.

Abstract: A luminaire includes a speaker positioned at a first depth within a luminaire housing and capable of generating an audio output from a speaker diaphragm. The luminaire also includes a light source that generates a light output. Further, the luminaire includes a light guide assembly positioned at a second depth within the luminaire housing different from the first depth. The light guide assembly includes an acoustically transparent area positioned along a sound path from the speaker diaphragm, and the light guide assembly extracts the light output from the light source and directs the light output away from the luminaire.

Abstract: A luminaire includes a light source positioned at a first level within a luminaire housing. The luminaire also includes a trim component positioned at a second level of the luminaire housing different from the first level. The trim component extends into a room from a ceiling surface and includes an aperture antenna that receives wireless signals and transmits wireless signals. Further, the luminaire includes a communication module that communicates wirelessly with one or more devices remote from the luminaire by controlling excitation of the aperture antenna.