Patents by Inventor Charles John Sih

Charles John Sih has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicycloalkyl derivatives of prostaglandins PGE.sub.1 alcohols
    Patent number: 4115453
    Abstract: Novel bicycloalkyl analogues or derivatives of prostaglandin A, E and F are useful modifiers of smooth muscle activity. The compounds have valuable pharmacological properties as platelet antiaggregating agents and gastric antisecretory agents. The compounds are also valuable pharmacological agents for increasing femoral blood flow and decreasing blood pressure and heart rate.
    Type: Grant
    Filed: July 22, 1977
    Date of Patent: September 19, 1978
    Assignee: Miles Laboratories, Inc.
    Inventors: Warren Dexter Woessner, Charles John Sih, Harold Clinton Kluender, Henry Clifford Arndt, William Gerard Biddlecom
  • Bicycloalkyl derivatives of prostaglandins 11-deoxy-PGE.sub.2 acids and esters
    Patent number: 4115438
    Abstract: Novel bicycloalkyl analogues or derivatives of prostaglandin A, E and F are useful modifiers of smooth muscle activity. The compounds have valuable pharmacological properties as platelet antiaggregating agents and gastric antisecretory agents. The compounds are also valuable pharmacological agents for increasing femoral blood flow and decreasing blood pressure and heart rate.
    Type: Grant
    Filed: July 21, 1977
    Date of Patent: September 19, 1978
    Assignee: Miles Laboratories, Inc.
    Inventors: Warren Dexter Woessner, Charles John Sih, Harold Clinton Kluender, Henry Clifford Arndt, William Gerard Biddlecom
  • Bicycloalkyl derivatives of prostaglandins: 11-deoxy-PGE.sub.1 acids and esters
    Patent number: 4108892
    Abstract: Novel bicycloalkyl analogues or derivatives of prostaglandin A, E, and F are useful modifiers of smooth muscle activity. The compounds have valuable pharmacological properties as platelet antiaggregating agents and gastric antisecretory agents. The compounds are also valuable pharmacological agents for increasing femoral blood flow and decreasing blood pressure and heart rate.
    Type: Grant
    Filed: July 22, 1977
    Date of Patent: August 22, 1978
    Assignee: Miles Laboratories, Inc.
    Inventors: Warren Dexter Woessner, Charles John Sih, Harold Clinton Kluender, Henry Clifford Arndt, William Gerard Biddlecom
  • Bicycloalkyl derivatives of prostaglandins
    Patent number: 4074063
    Abstract: Novel bicycloalkyl analogues or derivatives of prostaglandin A, E and F are useful modifiers of smooth muscle activity. The compounds have valuable pharmacological properties as platelet antiaggregating agents and gastric antisecretory agents. The compounds are also valuable pharmacological agents for increasing femoral blood flow and decreasing blood pressure and heart rate.
    Type: Grant
    Filed: February 11, 1976
    Date of Patent: February 14, 1978
    Assignee: Miles Laboratories, Inc.
    Inventors: Warren Dexter Woessner, Charles John Sih, Harold Clinton Kluender, Henry Clifford Arndt, William Gerard Biddlecom
  • Cycloalkenyl analogues of prostaglandins E
    Patent number: 4066834
    Abstract: Analogues of prostaglandins A, E, and F in which the C.sub.13 -C.sub.20 chain of the natural prostaglandins is replaced by a cycloalkenyl or a hydroxycycloalkenyl moiety such that vinylene radical and the hydroxyl group of the ring respectively retain their natural sequential positions at C.sub.13 -C.sub.14 and C.sub.15, inhibit aggregation of platelets in vitro and exhibit useful cardiovascular activity in vivo.
    Type: Grant
    Filed: October 20, 1975
    Date of Patent: January 3, 1978
    Assignee: Miles Laboratories, Inc.
    Inventors: Warren Dexter Woessner, William Gerard Biddlecom, Henry Clifford Arndt, George Peter Peruzzotti, Charles John Sih
  • Cycloalkylidenol analogues of prostaglandins E and F
    Patent number: 4029698
    Abstract: Analogues of prostaglandins E and F, in which the C.sub.15 hydroxyl group is incorporated into a cycloalkylidene moiety, stimulate smooth muscle.
    Type: Grant
    Filed: October 31, 1975
    Date of Patent: June 14, 1977
    Assignee: Miles Laboratories, Inc.
    Inventors: Warren Dexter Woessner, William Gerard Biddlecom, Henry Clifford Arndt, George Peter Peruzzotti, Charles John Sih
  • 11-Substitute d-11-desoxy-pge analogues
    Patent number: 3989744
    Abstract: 11-Substituted-11-desoxy-PGE and -PGF analogues, in which the 11-substituent may be phenyl, (substituted)phenyl, cycloalkyl, spiroalkyl, branched or linear alkyl and alkenyl, and 3-hydroxy-alkenyl, stimulate smooth muscle.
    Type: Grant
    Filed: July 30, 1973
    Date of Patent: November 2, 1976
    Assignee: Miles Laboratories, Inc.
    Inventors: Warren Dexter Woessner, Henry Clifford Arndt, William Gerard Biddlecom, George Peter Peruzzotti, Charles John Sih