Abstract: The disclosure is directed in non-limiting embodiments to compounds, compositions, and methods of treating conditions and diseases associated with activation of the gonadotropin GnRH receptor (GnRHR), particularly those involving GnRHR activating autoantibodies (GnRHR AAbs). In one non-limiting embodiment, the disease is Polycystic Ovary Syndrome (PCOS). The therapeutic compounds in at least certain embodiments include peptides which at least partially comprise D-amino acids, such as retro-inverso D-amino acid (RID) peptides, which are able to bind with high affinity to GnRHR AAbs.

Abstract: The disclosure is directed in non-limiting embodiments to compounds, compositions, and methods of treating conditions and diseases associated with activation of the gonadotropin GnRH receptor (GnRHR), particularly those involving GnRHR activating autoantibodies (GnRHR AAbs). In one non-limiting embodiment, the disease is Polycystic Ovary Syndrome (PCOS). The therapeutic compounds in at least certain embodiments include peptides which at least partially comprise D-amino acids, such as retro-inverso D-amino acid (RID) peptides, which are able to bind with high affinity to GnRHR AAbs.

Abstract: A firearm training safety device includes a cartridge loaded into the firearm, a rod to fit in the barrel of the firearm, a releasable fastening element which fastens the first end of the rod to the cartridge, and a colored safety indicator at the second end of the rod. The cartridge can be loaded into the firearm, and the rod can be inserted into the barrel and fastened to the cartridge, so that the firearm is rendered inoperable and the safety indicator extends from the barrel. The fastening element can be a threaded tunnel and funnel contained within the cartridge, and a threaded stud at the end of the rod.