Patents by Inventor Charles Kunsch
Charles Kunsch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6689360Abstract: The present invention relates to antiproliferative genes. More specifically, isolated nucleic acid molecules are provided encoding the human B-cell translocation genes 2 and 3 (BTG-2 and BTG-3). BTG-2 and BTG-3 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies to BTG-2 and BGT-3.Type: GrantFiled: April 30, 2001Date of Patent: February 10, 2004Assignee: Human Genome Sciences, Inc.Inventors: Charles A. Kunsch, Arvind Chopra, Craig A. Rosen
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Publication number: 20040023233Abstract: This invention is in the area of regulatory DNA sequences and their methods of use. Specifically, DNA sequences found in the regulatory region of cytoprotective genes are described that are termed cytoprotective response elements. DNA constructs also are provided that include cytoprotective response elements operably linked to heterologous protein coding sequence, as well as cells and non-human organisms that include the cytoprotective response elements optionally operably linked to a heterologous protein coding sequence, and a method for screening for a compound that increases mRNA or protein regulated by a cytoprotective response element. It has been discovered that the cytoprotective response elements mediate the coordinate activation of certain genes that protect cells from damaging effects of oxidative stress, and that they do so, for example during conditions of hemodynamic shear stress.Type: ApplicationFiled: October 16, 2002Publication date: February 5, 2004Inventors: Jayraz Luchoomun, Xilin Chen, Charles Kunsch, Signe E. Varner
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Patent number: 6593114Abstract: The present invention provides polynucleotide sequences of the genome of Staphylococcus aureus, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.Type: GrantFiled: October 20, 1997Date of Patent: July 15, 2003Assignee: Human Genome Sciences, Inc.Inventors: Charles A. Kunsch, Gil H. Choi, Steven Barash, Patrick J. Dillon, Michael R. Fannon, Craig A. Rosen
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Patent number: 6573082Abstract: The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.Type: GrantFiled: March 28, 2000Date of Patent: June 3, 2003Assignee: Human Genome Sciences, Inc.Inventors: Gil H. Choi, Charles A. Kunsch, Steven C. Barash, Patrick J. Dillon, Brian Dougherty, Michael R. Fannon, Craig A. Rosen
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Publication number: 20030054436Abstract: The present invention provides polynucleotide sequences of the genome of Staphylococcus aureus, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.Type: ApplicationFiled: January 3, 1997Publication date: March 20, 2003Inventors: CHARLES A. KUNSCH, GIL A. CHOI, STEVEN C. BARASH, PATRICK J. DILLON, MICHAEL R. FANNON, CRAIG A. ROSEN
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Publication number: 20030022312Abstract: A human hepatoma derived growth factor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the stimulation of tissue repair and tissue growth. Antagonists against such polypeptides and their use as a therapeutic to retard tumor growth and scarring is also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.Type: ApplicationFiled: November 15, 2001Publication date: January 30, 2003Applicant: Human Genome Sciences, Inc.Inventors: Charles A. Kunsch, Craig A. Rosen
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Publication number: 20030017495Abstract: The present invention relates to novel genes from E. faecalis and the polypeptides they encode. Also provided as are vectors, host cells, antibodies and methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of E. faecalis polypeptide activity. The invention additionally relates to diagnostic methods for detecting Enterococcus nucleic acids, polypeptides and antibodies in a biological sample. The present invention further relates to novel vaccines for the prevention or attenuation of infection by Enterococcus.Type: ApplicationFiled: July 29, 2002Publication date: January 23, 2003Applicant: Human Genome Sciences, Inc.Inventors: Gil H. Choi, Camella Bailey, Alex Hromockyj, Charles A. Kunsch
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Patent number: 6448043Abstract: The present invention relates to a novel gene from E. faecalis, EF040, and the encoded polypeptides. Also provided are vectors, host cells, antibodies and methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of E. faecalis EF040 polypeptide activity. The invention additionally relates to diagnostic methods for detecting Enterococcus EF040 nucleic acids, encoded polypeptides and anti-EF040 antibodies in a biological sample. The present invention further relates to novel vaccines for the prevention or attenuation of infection by Enterococcus.Type: GrantFiled: May 4, 1998Date of Patent: September 10, 2002Assignee: Human Genome Sciences, Inc.Inventors: Gil H. Choi, Camella Bailey, Alex Hromockyj, Charles A. Kunsch
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Publication number: 20020120116Abstract: The present invention provides polynucleotide sequences of the genome of Enterococcus faecalis, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.Type: ApplicationFiled: May 4, 1998Publication date: August 29, 2002Inventors: CHARLES A. KUNSCH, PATRICK J. DILLON, STEVEN BARASH
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Publication number: 20020106678Abstract: Nucleic acid molecules encoding human &ggr;2, &ggr;3, &ggr;4, &ggr;5, &ggr;7, &ggr;10 and &ggr;11 subunits are provided. Subunit polypeptides are also provided. In addition, method of detecting mutated forms of human &ggr; subunit and altered levels of human &ggr; subunit are provided. Methods of identifying antagonists and agonists of the interaction of a &bgr;&ggr; ligand with its receptor are also provided.Type: ApplicationFiled: October 22, 2001Publication date: August 8, 2002Inventors: Janet D. Robishaw, Charles A. Kunsch
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Patent number: 6420135Abstract: The present invention provides polynucleotide sequences of the genome of Streptococcus pneumoniae, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.Type: GrantFiled: October 30, 1997Date of Patent: July 16, 2002Assignee: Human Genome Sciences, Inc.Inventors: Charles A. Kunsch, Gil H. Choi, Patrick S. Dillon, Craig A. Rosen, Steven C. Barash, Michael R. Fannon, Brian A. Dougherty
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Publication number: 20020061545Abstract: The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.Type: ApplicationFiled: January 22, 2001Publication date: May 23, 2002Inventors: Gil H. Choi, Charles A. Kunsch, Steven C. Barash, Patrick J. Dillon, Brian Dougherty, Michael R. Fannon, Craig A. Rosen
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Publication number: 20020045737Abstract: The present invention relates to novel genes from E. faecalis and the polypeptides they encode. Also provided as are vectors, host cells, antibodies and methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of E. faecalis polypeptide activity. The invention additionally relates to diagnostic methods for detecting Enterococcus nucleic acids, polypeptides and antibodies in a biological sample. The present invention further relates to novel vaccines for the prevention or attenuation of infection by Enterococcus.Type: ApplicationFiled: May 4, 1998Publication date: April 18, 2002Applicant: HUMAN GENOME SCIENCES, INC.Inventors: GIL H. CHOI, CAMELLA BAILEY, ALEX HROMOCKYJ, CHARLES A. KUNSCH
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Publication number: 20020042362Abstract: The present invention relates to novel antiproliferative genes. More specifically, isolated nucleic acid molecules are provided encoding the human B-cell translocation genes 2 and 3 (BTG-2 and BTG-3). BTG-2 and BTG-3 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same.Type: ApplicationFiled: April 30, 2001Publication date: April 11, 2002Applicant: Human Genome Sciences, Inc.Inventors: Charles A. Kunsch, Arvind Chopra, Craig A. Rosen
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Publication number: 20020032323Abstract: The present invention provides polynucleotide sequences of the genome of Streptococcus pneumoniae, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.Type: ApplicationFiled: October 30, 1997Publication date: March 14, 2002Inventors: CHARLES A. KUNSCH, GIL H. CHOI, PATRICK J. DILLON, CRAIG A. ROSEN, STEVEN C. BARASH, MICHAEL R. FANNON, BRIAN A. DOUGHERTY
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Publication number: 20010010934Abstract: The present invention relates to a novel human protein called Prostate Derived Ets Factor, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.Type: ApplicationFiled: July 31, 1998Publication date: August 2, 2001Inventors: TOWIA ARON LIBERMANN, JOERG PETER OETTGEN, CHARLES A. KUNSCH, GREGORY A. ENDRESS, CRAIG A. ROSEN
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Patent number: 6258777Abstract: The present invention relates to novel antiproliferative genes. More specifically, isolated nucleic acid molecules are provided encoding the human B-cell translocation genes 2 and 3 (BTG-2 and BTG-3). BTG-2 and BTG-3 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same.Type: GrantFiled: December 29, 1998Date of Patent: July 10, 2001Assignee: Human Genome Sciences, Inc.Inventors: Charles A. Kunsch, Arvind Chopra, Craig A. Rosen
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Patent number: 6159469Abstract: The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.Type: GrantFiled: October 30, 1997Date of Patent: December 12, 2000Assignee: Human Genome Sciences, Inc.Inventors: Gil H. Choi, Charles A. Kunsch, Steven C. Barash, Patrick J. Dillon, Brian Dougherty, Michael R. Fannon, Craig A. Rosen
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Patent number: 6013469Abstract: The present invention relates to novel antiproliferative genes. More specifically, isolated nucleic acid molecules are provided encoding the human B-cell translocation genes 2 and 3 (BTG-2 and BTG-3). BTG-2 and BTG-3 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same.Type: GrantFiled: September 18, 1996Date of Patent: January 11, 2000Assignee: Human Genome Sciences, Inc.Inventors: Charles A. Kunsch, Arvind Chopra, Craig A. Rosen
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Patent number: 5721113Abstract: Isolated nucleic acids encoding human lymphoid-specific transcription factors NERF-1 and NERF-2, proteins obtainable from the nucleic acids, recombinant host cells transformed with the nucleic acids and use of the proteins and nucleic acid sequences are dislcosed.Type: GrantFiled: January 3, 1995Date of Patent: February 24, 1998Assignee: Human Genome Sciences, Inc.Inventors: Towia Aron Libermann, Joerg Peter Oettgen, Charles A. Kunsch