Patents by Inventor Charles L. Bevins

Charles L. Bevins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BETA-DEFENSIN 2 GENETIC VARIATION PREDICTS H. PYLORI SUSCEPTIBILITY
    Publication number: 20120214705
    Abstract: The present invention relates to correlating high gene copy number and/or the overexpression of ?-defensin 2 (“BD2”) with susceptibility to disease conditions resulting from, associated with or mediated by Helicobacter pylori infection, for example, susceptibility to peptic ulcer, non-ulcer dyspepsia, gastric cancer (e.g., gastric adenocarcinoma), and mucosa associated lymphoid tissue (MALT) lymphoma.
    Type: Application
    Filed: September 27, 2010
    Publication date: August 23, 2012
    Applicant: The Regents Of The University Of California Office of Technology,
    Inventors: Charles L. Bevins, Jay V. Solnick, Michael J. Hornsby, Robert J. Kays
  • INFERTILITY ASSOCIATED DEFB-126 DELETION POLYMORPHISM
    Publication number: 20120077758
    Abstract: The present application provides diagnostic methods for determining the fertility status of a male individual by evaluating his DEFB-126 phenotypic and genotypic status. The present invention relates to a dinucleotide deletion polymorphism in the protein coding sequence of a DEFB-126 nucleic acid. The amino acid sequence of this variant has a significantly altered the carboxyl terminal, carbohydrate-containing domain of DEFB-126 in comparison to a wild-type DEFB-126 polypeptide. This variant results in aberrant protein function and structure, leading to reduced sperm function and fertility. The present invention provides methods for analyzing the genotype of individuals with respect to the gene encoding DEFB-126 in order to determine whether that individual has reduced fertility. Such determination will provide an individual knowledge of whether their genotype is associated with a risk of reduced fertility and to allow that individual to receive appropriate fertility treatment options.
    Type: Application
    Filed: February 26, 2010
    Publication date: March 29, 2012
    Applicants: Board of Trustees of the University of Illinois, The Regents of the University of California
    Inventors: Charles L. Bevins, Tsang Lau, Gary N. Cherr, Ashley I. Yudin, Theodore L. Tollner, James W. Overstreet, Scott Venners, Xiping Xu
  • Gastrointestinal defensins, cDNA sequences and method for the production and use thereof
    Patent number: 5641497
    Abstract: This invention provides gastrointestinal peptides useful as antimicrobial and anti-inflammatory agents. This invention also provides methods for producing peptides, pharmaceutical compositions containing the gastrointestinal defensin peptides, and methods of use thereof. Methods of diagnosing gastrointestinal disorders are also provided.
    Type: Grant
    Filed: November 24, 1993
    Date of Patent: June 24, 1997
    Assignee: Children's Hospital Of Philadelphia
    Inventors: Charles L. Bevins, Douglas E. Jones
  • DNA encoding tracheal antimicrobial peptides
    Patent number: 5432270
    Abstract: The present invention provides a new class of polypeptides with antimicrobial activity, termed "tracheal antimicrobial peptides," DNA and cDNA sequences encoding for the peptides and methods for the production and use thereof.
    Type: Grant
    Filed: May 11, 1993
    Date of Patent: July 11, 1995
    Inventors: Michael A. Zasloff, Charles L. Bevins, Gill Diamond
  • Tracheal antimicrobial peptides, DNA sequences and methods for the production and use thereof
    Patent number: 5202420
    Abstract: The present invention provides a new class of polypeptides with antimicrobial activity, termed "tracheal antimicrobial peptides," cDNA sequences encoding for the peptides and methods for the production and use thereof.
    Type: Grant
    Filed: October 25, 1990
    Date of Patent: April 13, 1993
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Michael A. Zasloff, Charles L. Bevins, Gill Diamond