Patents by Inventor Charles L. Ginther

Charles L. Ginther has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Moesin, caveolin 1 and yes associated protein 1 as predictive markers of response to dasatinib in breast cancers
    Patent number: 8007995
    Abstract: The invention described herein relates to methods and compositions useful in the diagnosis, treatment and management of cancers that express particular genes, including the moesin, caveolin 1, and/or yes-associated protein 1 genes.
    Type: Grant
    Filed: November 10, 2006
    Date of Patent: August 30, 2011
    Assignees: Bristol-Myers Squibb Company, The Regents of the University of California
    Inventors: Richard S. Finn, Judy Dering, Dennis J. Slamon, Charles L. Ginther, Edwin A. Clark
  • IDENTIFICATION OF PREDICTIVE MARKERS OF RESPONSE TO DASATINIB IN HUMAN COLON CANCER
    Publication number: 20110166154
    Abstract: Methods and compositions are provided useful in the diagnosis, treatment and management of cancers wherein cancer cells express certain polynucleotides and/or polypeptides that are differentially expressed in colon cancer subtypes that are sensitive to therapy with abl kinase inhibitors and src kinase inhibitors. In particular, PTK-7, PLK-2 and PLK-3 could be identified as markers for determining the responsiveness of cancer to dasatinib.
    Type: Application
    Filed: January 23, 2009
    Publication date: July 7, 2011
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Dennis J. Slamon, Richard S. Finn, Judy Dering, J. Randolph Hecht, Zev A. Wainberg, Edwin A. Clark, Charles L. Ginther
  • MOESIN, CAVEOLIN 1 AND YES ASSOCIATED PROTEIN 1 AS PREDICTIVE MARKERS OF RESPONSE TO DASATINIB IN BREAST CANCERS
    Publication number: 20090170866
    Abstract: The invention described herein relates to methods and compositions useful in the diagnosis, treatment and management of cancers that express particular genes, including the moesin, caveolin 1, and/or yes-associated protein 1 genes.
    Type: Application
    Filed: November 10, 2006
    Publication date: July 2, 2009
    Applicants: Bristol-Myers Squibb Pharma Company, The Regents of the University of California
    Inventors: Richard S. Finn, Judy Dering, Dennis J. Slamon, Charles L. Ginther, Edwin A. Clark
  • Amplified and overexpressed gene in colorectal cancers
    Patent number: 7537905
    Abstract: This invention relates to methods to diagnose colon cancer and other proliferative diseases. Gene 26#77 is identified herein as a novel oncogene. Methods are provided for diagnosing and treating a disease or disorder characterized by amplification of the 26#77 gene and/or overexpression of 26#77 gene products. The 26#77 gene is located on chromosome 20q13.2, a region whose amplification is associated with a poor cancer prognosis. The 26#77 gene is amplified and 26#77 RNA and protein are overexpressed in 60% of colorectal cancers.
    Type: Grant
    Filed: January 15, 2003
    Date of Patent: May 26, 2009
    Assignee: The Regents of the University of California
    Inventors: Dennis J. Slamon, Lee A. Anderson, Charles L. Ginther
  • Amplified and overexpressed gene in colorectal cancers
    Publication number: 20040137442
    Abstract: This invention relates to methods to diagnose colon cancer and other proliferative diseases. Gene 26#77 is identified herein as a novel oncogene. Methods are provided for diagnosing and treating a disease or disorder characterized by amplification of the 26#77 gene and/or overexpression of 26#77 gene products. The 26#77 gene is located on chromosome 20q13.2, a region whose amplification is associated with a poor cancer prognosis. The 26#77 gene is amplified and 26#77 RNA and protein are overexpressed in 60% of colorectal cancers.
    Type: Application
    Filed: January 15, 2003
    Publication date: July 15, 2004
    Applicant: REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Dennis J. Slamon, Lee A. Anderson, Charles L. Ginther