Abstract: This document provides materials and methods for treating a damaged optic nerve in a mammal to restore visual function comprising administering a population of induced pluripotent stem cell-derived oligodendrocyte precursor cells. This document also provides materials and methods for determining a remyelination potential quotient of a population of induced pluripotent stem cell-derived oligodendrocyte precursor cells. This document also provides materials and methods for screening factors that enhance maturation or myelination efficiency of an induced pluripotent stem cell-derived oligodendrocyte precursor cell or cells.

Abstract: Materials and methods for identifying subjects as being likely or not likely to respond to an interleukin-1? receptor antagonist (IL-1RA) therapy for a seizure disorder, as well as materials and methods for treating subjects identified as being likely to respond to an IL-1RA therapy for a seizure disorder, are provided herein.

Abstract: This document provides materials and methods for treating a damaged optic nerve in a mammal to restore visual function comprising administering a population of induced pluripotent stem cell-derived oligodendrocyte precursor cells. This document also provides materials and methods for determining a remyelination potential quotient of a population of induced pluripotent stem cell-derived oligodendrocyte precursor cells. This document also provides materials and methods for screening factors that enhance maturation or myelination efficiency of an induced pluripotent stem cell-derived oligodendrocyte precursor cell or cells.

Abstract: Methods of treating neurological inflammatory disease or seizures caused by neuroinflammation by administering cPMP are described. Treating neuroinflammatory and neurometabolic diseases with cPMP is described so as to override dyshomeostasis in the MoCo synthesis pathway and control synaptic inhibition in the gephyrin-GABAR pathway. This is a novel strategy for preventing neural circuit dyshomeostasis by stabilizing inhibitory synapses.

Abstract: Provided herein are methods for transporting an infectious agent (e.g., a virus) across the blood-brain barrier (BBB). For example, the methods provided herein can be used to make a non-human animal model of an infectious brain disease. In some embodiments, the methods provided herein can be used to make a mouse model of multiple sclerosis.

Abstract: Apparatus for constructing a temporary, removable tennis court on a paved vehicle parking lot are described. Provisions are made for two contrasting types of pavement markings, and for two sets of socket holes in the pavement which receive complementary posts for nets and fencing, allowing quick and easy change from parking lot use to tennis court use and back again.