Patents by Inventor Charles L. Sawyers

Charles L. Sawyers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diarylhydantoin compounds
    Patent number: 7709517
    Abstract: The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.
    Type: Grant
    Filed: May 15, 2006
    Date of Patent: May 4, 2010
    Assignee: The Regents of the University of California
    Inventors: Charles L. Sawyers, Michael E. Jung, Charlie D. Chen, Samedy Ouk, Derek Welsbie, Chris Tran, John Wongvipat, Dongwon Yoo
  • Mutations in the BCR-ABL tyrosine kinase associated with resistance to ST1-571
    Publication number: 20100055687
    Abstract: The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
    Type: Application
    Filed: March 11, 2009
    Publication date: March 4, 2010
    Inventors: Charles L. Sawyers, Mercedes E. Gorre, Neil Pravin Shah, John Nicoll
  • T315A AND F317I MUTATIONS OF BCR-ABL KINASE DOMAIN
    Publication number: 20100029676
    Abstract: The present invention relates to mutant BCR-ABL kinase proteins, and to diagnostic and therapeutic methods and compositions useful in the management of disorders, for example cancers, involving cells that express such mutant BCR-ABL kinase proteins.
    Type: Application
    Filed: November 3, 2006
    Publication date: February 4, 2010
    Inventors: Charles L. Sawyers, Michael Burgess, Neil Pravin Shah, Francis Y. Lee, John S. Tokarski, Herbert E. Klei
  • Mouse models of human prostate cancer
    Patent number: 7595431
    Abstract: The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
    Type: Grant
    Filed: September 12, 2006
    Date of Patent: September 29, 2009
    Assignee: The Regents of the University of California
    Inventors: Charles L. Sawyers, Karen A. Klein, Owen N. Witte, Robert E. Reiter
  • Methods of Identifying and Treating Individuals Exhibiting Complex Karyotypes
    Publication number: 20090197893
    Abstract: The invention described herein relates to diagnostic and therapeutic methods and compositions useful in the management of disorders, for example cancers, involving cells that harbor complex karyotypes. The present invention also related to mutant BCR-ABL kinase proteins, and to diagnostic and therapeutic methods and compositions useful in the management of disorders, for example cancers, involving cells that express such mutant BCR-ABL kinase proteins.
    Type: Application
    Filed: November 30, 2006
    Publication date: August 6, 2009
    Inventors: Francis Y. Lee, Charles L. Sawyers, Neil P. Shah
  • Mutations in the BCR-ABL tyrosine kinase associated with resistance to STI-571
    Publication number: 20090155787
    Abstract: The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
    Type: Application
    Filed: April 4, 2008
    Publication date: June 18, 2009
    Inventors: Charles L. Sawyers, Mercedes E. Gorre, Neil Pravin Shah, John Nicoll
  • DIARYLHYDANTOIN COMPOUNDS
    Publication number: 20090111864
    Abstract: The present invention relates to diarylhydantoin compounds and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.
    Type: Application
    Filed: October 24, 2008
    Publication date: April 30, 2009
    Applicant: The Regents of the University of California
    Inventors: MICHAEL E. JUNG, Dongwon Yoo, Charles L. Sawyers, Chris Tran
  • Mutations in the Bcr-Abl tyrosine kinase associated with resistance to STI-571
    Patent number: 7521175
    Abstract: The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: April 21, 2009
    Assignee: The Regents of the University of California
    Inventors: Charles L. Sawyers, Mercedes E. Gorre, Neil Pravin Shah, John Nicoll
  • Biomarker for Sensitivity to mTOR Inhibitor Therapy in Kidney Cancer
    Publication number: 20090098537
    Abstract: The invention disclosed herein provides methods for the examination and/or quantification of biochemical pathways that are disregukted in pathologies such as cancer and to reagents and kits adapted for performing such methods. For example a correlation between VHL loss and mTOR inhibitor sensitivity in human kidney cancer cells is disclosed, indicating that VHL loss confers autonomous and angiogenic competitive advantages to such cells.
    Type: Application
    Filed: March 17, 2006
    Publication date: April 16, 2009
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Charles L. Sawyers, George V. Thomas
  • Methods and Materials for Examining the P13k/Akt Pathway in Gliomas and Prostate Cancers
    Publication number: 20080299589
    Abstract: The invention disclosed herein provides methods for the examination and/or quantification of the PI3K/Akt and Ras/MAPK biochemical pathways that are disregulated in pathologies such as cancers of the prostate and gliomas. The invention disclosed herein further provides reagents and kits adapted for performing such methods.
    Type: Application
    Filed: November 8, 2004
    Publication date: December 4, 2008
    Applicant: The Regents of the University of California
    Inventors: Charles L. Sawyers, George V. Thomas
  • Mouse models of human prostate cancer
    Patent number: 7122714
    Abstract: The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
    Type: Grant
    Filed: February 4, 2002
    Date of Patent: October 17, 2006
    Assignee: The Regents of the University of California
    Inventors: Charles L. Sawyers, Karen A. Klein, Owen N. Witte, Robert E. Reiter
  • Mouse models of human prostate cancer progression
    Patent number: 7053263
    Abstract: The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
    Type: Grant
    Filed: December 14, 2001
    Date of Patent: May 30, 2006
    Assignee: The Regents of the University of California
    Inventors: Charles L. Sawyers, Karen A. Klein, Owen N. Witte, Robert E. Reiter
  • E25A protein, methods for producing and use thereof
    Patent number: 7030232
    Abstract: The invention provides a human E25a protein which is upregulated in cancerous cells, including those of hormone refractory prostate cancer, colon cancer, breast cancer or other cancers of epithelial origin. The invention also provides nucleic acid molecules encoding E25a protein, nucleic acid probes which hybridize with nucleic acid molecules encoding E25a protein, and antibodies which bind E25a protein. E25a protein and its related molecules can be useful as diagnostic markers of cancer, including hormone refractory prostate cancer, and as specific therapeutic targets in this disease. The invention also provides methods for diagnosing cancer, including hormone refractory prostate cancer.
    Type: Grant
    Filed: November 29, 1999
    Date of Patent: April 18, 2006
    Assignee: The Regents of the University of California
    Inventors: Robert E. Reiter, Owen N. Witte, Charles L. Sawyers
  • Mice models of human prostate cancer progression
    Patent number: 6956145
    Abstract: The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
    Type: Grant
    Filed: January 30, 2002
    Date of Patent: October 18, 2005
    Assignee: The Regents of the University of California
    Inventors: Charles L Sawyers, Karen A. Klein, Owen N. Witte, Robert E Reiter
  • Methods of assessing the effect of a gene of interest on human prostate cancer progression
    Patent number: 6949690
    Abstract: The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
    Type: Grant
    Filed: January 30, 2002
    Date of Patent: September 27, 2005
    Assignee: The Regents of the University of California
    Inventors: Charles L. Sawyers, Karen A. Klein, Owen N Witte, Robert E. Reiter
  • Mice models of human prostate cancer
    Patent number: 6828471
    Abstract: The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
    Type: Grant
    Filed: January 30, 2002
    Date of Patent: December 7, 2004
    Assignee: The Regents of the University of California
    Inventors: Charles L. Sawyers, Karen A. Klein, Owen N. Witte, Robert E. Reiter
  • Methods of simulating human prostate cancer progression
    Patent number: 6815574
    Abstract: The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
    Type: Grant
    Filed: January 30, 2002
    Date of Patent: November 9, 2004
    Assignee: The Regents of the University of California
    Inventors: Charles L. Sawyers, Karen A. Klein, Owen N. Witte, Robert E. Reiter
  • Methods and materials for examining pathways associated with glioblastoma progression
    Publication number: 20040106141
    Abstract: The invention disclosed herein provides methods for the examination and/or quantification of biochemical pathways that are disregulated in pathologies such as cancer and to reagents and kits adapted for performing such methods.
    Type: Application
    Filed: November 5, 2003
    Publication date: June 3, 2004
    Applicant: The Regents of the University of California
    Inventors: Paul S. Mischel, Charles L. Sawyers, Bradley L. Smith, Katherine Crosby
  • Mutations in the Bcr-Abl tyrosine kinase associated with resistance to STI-571
    Publication number: 20030158105
    Abstract: The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
    Type: Application
    Filed: June 14, 2002
    Publication date: August 21, 2003
    Inventors: Charles L. Sawyers, Mercedes E. Gorre, Neil Pravin Shah, John Nicoll
  • Purified human prostate cancer cells
    Publication number: 20020144301
    Abstract: The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
    Type: Application
    Filed: February 4, 2002
    Publication date: October 3, 2002
    Applicant: The Regents of the University of California
    Inventors: Charles L. Sawyers, Karen A. Klein, Owen N. Witte, Robert E. Reiter