Patents by Inventor Charles L. Sentman

Charles L. Sentman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHIMERIC NK RECEPTOR AND METHODS FOR TREATING CANCER
    Publication number: 20120029063
    Abstract: The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif. Methods for using the chimeric receptors are further provided.
    Type: Application
    Filed: June 8, 2011
    Publication date: February 2, 2012
    Applicant: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: TONG ZHANG, CHARLES L. SENTMAN
  • Chimeric NK receptor and methods for treating cancer
    Patent number: 7994298
    Abstract: The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif. Methods for using the chimeric receptors are further provided.
    Type: Grant
    Filed: August 31, 2005
    Date of Patent: August 9, 2011
    Assignee: Trustees of Dartmouth College
    Inventors: Tong Zhang, Charles L. Sentman
  • Female Reproductive Tract and Anal Prophylaxes
    Publication number: 20110104121
    Abstract: The present invention provides methods for boosting mucosal immunity in the female reproductive tract of pre- and post-menopausal women using a TGF-beta inhibitor, a Selective Estrogen Receptor Modulator, and/or a recombinant commensal bacterium that expresses endogenous microbicides into the intestinal tract or reproductive tract of a subject. It also provides methods for boosting innate and adaptive immunity by providing a glucocorticoid. Methods for preventing sexually transmitted infections including HIV infection are also provided.
    Type: Application
    Filed: May 21, 2009
    Publication date: May 5, 2011
    Inventors: Charles R. Wira, John V. Fahey, Charles L. Sentman, Paul M. Guyre
  • Chimeric NK Receptor and Methods for Treating Cancer
    Publication number: 20100029749
    Abstract: The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif. Methods for using the chimeric receptors are further provided.
    Type: Application
    Filed: August 31, 2005
    Publication date: February 4, 2010
    Inventors: Tong Zhang, Charles L. Sentman
  • Chimeric NK receptor and methods for treating cancer
    Publication number: 20090202501
    Abstract: The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif. Methods for using the chimeric receptors are further provided.
    Type: Application
    Filed: March 19, 2009
    Publication date: August 13, 2009
    Inventors: Tong Zhang, Charles L. Sentman