Abstract: Provided herein are E. coli host strains with improved capacity for producing recombinant proteins.

Abstract: Provided herein are E. coli host strains with improved capacity for producing recombinant proteins.

Abstract: Provided herein are methods for the improved production of periplasmic-targeted recombinant proteins in E. coli host strains. Also provided are E. coli host strains with improved capacity for producing recombinant proteins.

Abstract: A cooling system used in an X-ray generator having a cathode and anode that includes a target having a focal spot, wherein heat is generated in the anode and focal spot during operation of the X-ray generator. The system includes a heat transfer element attached to the anode wherein the heat transfer element includes a plurality of fin elements that transfer heat from the anode to surrounding air to cool the anode. The system also includes a liquid channel formed in the anode, wherein the liquid channel includes a cooling liquid. The liquid channel is located adjacent the target wherein heat from the focal spot is transferred to the cooling liquid to cool the focal spot wherein the heat transfer element, liquid channel and anode are unistructurally formed. Further, the cooling system includes a circulation pump that moves the cooling liquid in the liquid channel.

Abstract: A patient support mechanism that supports a patient during scanning of the patient by a medical scanner. The support mechanism includes a shoulder support rotatably attached to a head support. The head support receives the patient's head and the shoulder support receives an upper portion of the patient's body wherein the shoulder support includes a downwardly extending attachment device. The support mechanism also includes an attachment mechanism having a post section that is attached to the medical scanner. Further, the attachment mechanism includes a bracket element for receiving the attachment device wherein the shoulder support is attached to the bracket element by positioning the shoulder support above the bracket element and moving the shoulder support downward to attach the attachment device to the bracket element while the patient is lying in bed.

Abstract: A cooling system used in an X-ray generator having a cathode and anode that includes a target having a focal spot, wherein heat is generated in the anode and focal spot during operation of the X-ray generator. The system includes a heat transfer element attached to the anode wherein the heat transfer element includes a plurality of fin elements that transfer heat from the anode to surrounding air to cool the anode. The system also includes a liquid channel formed in the anode, wherein the liquid channel includes a cooling liquid. The liquid channel is located adjacent the target wherein heat from the focal spot is transferred to the cooling liquid to cool the focal spot wherein the heat transfer element, liquid channel and anode are unistructurally formed. Further, the cooling system includes a circulation pump that moves the cooling liquid in the liquid channel.

Abstract: The present invention relates to the use of redox agents for purification of the CRM 197 variant of diphtheria toxin. The invention further relates to multi-step purification of CRM 197 from bacterial fermentates.

Abstract: Provided herein are methods for the improved production of periplasmic-targeted recombinant proteins in E. coli host strains. Also provided are E. coli host strains with improved capacity for producing recombinant proteins.

Abstract: The present invention relates to the use of redox agents for purification of the CRM 197 variant of diphtheria toxin. The invention further relates to multi-step purification of CRM 197 from bacterial fermentates.

Abstract: A computed tomography system has an x-ray source, x-ray detector, a gantry, and a controller configured to automatically initiate an air-calibration using the source and detector with air in an air space and to determine gain values for channels of the detector from the automatically initiated air-calibration. A computed tomography system having a patient bore, a controller, an x-ray source, and a detector is calibrated by receiving a setting for a medical scan to be performed by the computed tomography system for a particular patient, the setting being one of a plurality of optional values, scanning air and not the patient in the patient bore with the source and the detector using the setting, determining a gain value based on the scanning with the setting and not the other optional values, and scanning the patient with the source and the detector using the setting and the gain value.

Abstract: A computed tomography system has an x-ray source, x-ray detector, a gantry, and a controller configured to automatically initiate an air-calibration using the source and detector with air in an air space and to determine gain values for channels of the detector from the automatically initiated air-calibration. A computed tomography system having a patient bore, a controller, an x-ray source, and a detector is calibrated by receiving a setting for a medical scan to be performed by the computed tomography system for a particular patient, the setting being one of a plurality of optional values, scanning air and not the patient in the patient bore with the source and the detector using the setting, determining a gain value based on the scanning with the setting and not the other optional values, and scanning the patient with the source and the detector using the setting and the gain value.

Abstract: A jumpseat for an emergency transport vehicle having a patient compartment that includes a medical scanning device and a patient stretcher having a stretcher axis. The jumpseat includes a post element rotatably attached to a floor portion of the patient compartment, wherein the floor portion is located in a clearance space between the scanning device and a head end of the stretcher. The jumpseat also includes a seating element rotatably attached to the post element. The post and seating elements are moveable between a stowed position wherein the post element and seating element are substantially horizontal and a deployed position wherein the post element is substantially vertical and the seating element is substantially horizontal and located in the clearance space and in-line with a patient's body axis.

Abstract: A jumpseat for an emergency transport vehicle having a patient compartment that includes a medical scanning device and a patient stretcher having a stretcher axis. The jumpseat includes a post element rotatably attached to a floor portion of the patient compartment, wherein the floor portion is located in a clearance space between the scanning device and a head end of the stretcher. The jumpseat also includes a seating element rotatably attached to the post element. The post and seating elements are moveable between a stowed position wherein the post element and seating element are substantially horizontal and a deployed position wherein the post element is substantially vertical and the seating element is substantially horizontal and located in the clearance space and in-line with a patient's body axis.

Abstract: Methods for prophylaxis or treatment of sepsis in a subject are provided comprising administering to the subject a therapeutically effective dose of multiple deletion strain bacteria.

Abstract: Methods for prophylaxis or treatment of sepsis in a subject are provided comprising administering to the subject a therapeutically effective dose of multiple deletion strain bacteria.

Abstract: An integrated energy hub facility capable of bringing together all aspects of hydrocarbon and other fluid product movement under controlled conditions applicable to the reception, storage, processing, collection and transmission downstream is provided. Input to the energy hub includes natural gas and crude from a pipeline or a carrier, LNG from a carrier, CNG from a carrier, and carrier-regassed LNG, as well as other products from a pipeline or a carrier. Storage can be above surface, in salt caverns or in subterranean formations and cavities, and include petroleum crude, natural gas, LPG, NGL, GTL and other fluids. Transmission downstream may be carried out by a vessel or other type of carrier and/or by means of a pipeline system. Cryogenic fluids are offloaded and sent to the energy hub surface holding tank, then pumped to the energy hub vaporizers and sent to underground storage and/or distribution.

Abstract: An integrated energy hub facility capable of bringing together all aspects of hydrocarbon and other fluid product movement under controlled conditions applicable to the reception, storage, processing, collection and transmission downstream is provided. Input to the energy hub includes natural gas and crude from a pipeline or a carrier, LNG from a carrier, CNG from a carrier, and carrier-regassed LNG, as well as other products from a pipeline or a carrier. Storage can be above surface, in salt caverns or in subterranean formations and cavities, and include petroleum crude, natural gas, LPG, NGL, GTL and other fluids. Transmission downstream may be carried out by a vessel or other type of carrier and/or by means of a pipeline system. Cryogenic fluids are offloaded and sent to the energy hub surface holding tank, then pumped to the energy hub vaporizers and sent to underground storage and/or distribution.

Abstract: An integrated energy hub facility capable of bringing together all aspects of hydrocarbon and other fluid product movement under controlled conditions applicable to the reception, storage, processing, collection and transmission downstream is provided. Input to the energy hub includes natural gas and crude from a pipeline or a carrier, LNG from a carrier, CNG from a carrier, and carrier-regassed LNG, as well as other products from a pipeline or a carrier. Storage can be above surface, in salt caverns or in subterranean formations and cavities, and include petroleum crude, natural gas, LPG, NGL, GTL and other fluids. Transmission downstream may be carried out by a vessel or other type of carrier and/or by means of a pipeline system. Cryogenic fluids are offloaded and sent to the energy hub surface holding tank, then pumped to the energy hub vaporizers and sent to underground storage and/or distribution.

Abstract: A method and a system are provided for the safe berthing of marine vessels in the high seas and other unprotected open waters. The invention allows a large vessel to be berthed alongside in close enough proximity to a marine structure so that conventional loading arm equipment may be used to load and unload the vessel under most environmental conditions. One or more floating dolphins moored to the bottom of the sea and provided with fendering means are used for berthing the vessel alongside to the marine structure. The preferred type of floating dolphin is a triangular semi-submersible moored buoyant structure comprising three buoyant column members, or “caissons”, arranged invertical fashion, three buoyant hull segments, or “pontoons”, that support and separate the column members and provide heave damping to the moored buoyant structure, and three horizontal bracing members that retain the tops of the column members in place.

Abstract: A method is provided for simultaneously developing caverns while depositing wastes or other materials in them. A well is first drilled into a salt formation and the development of a salt cavern by means of solution mining is initiated. When the development of the cavern has been carried out to an extent sufficient to accommodate the injection of a prescribed amount of wastes or other materials, injection of the wastes or other materials through the well is started while continuing to develop the cavern by solution mining. The injection of the wastes or other materials may be carried out continuously or intermittently. The proportion and rates of wastes or other materials and mining water injected into the well are monitored and regulated so that cavern development continues at a rate that allows the cavern to reach an intended prescribed size while the wastes or other materials are injected and deposited into the cavern.