Patents by Inventor Charles Large

Charles Large has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulators of Kv3 channels to treat pain
    Patent number: 11944623
    Abstract: The present invention provides a modulator of Kv3.1 and/or Kv3.2 and/or Kv3.3 channels for use in the prophylaxis or treatment of pain.
    Type: Grant
    Filed: September 10, 2021
    Date of Patent: April 2, 2024
    Assignee: AUTIFONY THERAPEUTICS LIMITED
    Inventors: Charles Large, Giuseppe Alvaro
  • Hydantoin derivatives useful as Kv3 inhibitors
    Patent number: 11583527
    Abstract: The disclosure provides compounds of formula (I): said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Grant
    Filed: November 2, 2021
    Date of Patent: February 21, 2023
    Assignee: AUTIFONY THERAPEUTICS LIMITED
    Inventors: Giuseppe Alvaro, Paolo Dambruoso, Simona Tommasi, Anne Decor, Charles Large, Agostino Marasco
  • MODULATORS OF KV3 CHANNELS TO TREAT PAIN
    Publication number: 20220071998
    Abstract: The present invention provides a modulator of Kv3.1 and/or Kv3.2 and/or Kv3.3 channels for use in the prophylaxis or treatment of pain.
    Type: Application
    Filed: September 10, 2021
    Publication date: March 10, 2022
    Inventors: Charles LARGE, Giuseppe ALVARO
  • HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS
    Publication number: 20220054490
    Abstract: The disclosure provides compounds of formula (I): said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Application
    Filed: November 2, 2021
    Publication date: February 24, 2022
    Inventors: Giuseppe Alvaro, Paolo Dambruoso, Simona Tommasi, Anne Decor, Charles Large, Agostino Marasco
  • Hydantoin derivatives useful as Kv3 inhibitors
    Patent number: 11197859
    Abstract: The disclosure provides compounds of formula (I): said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Grant
    Filed: August 4, 2020
    Date of Patent: December 14, 2021
    Assignee: AUTIFONY THERAPEUTICS LIMITED
    Inventors: Giuseppe Alvaro, Paolo Dambruoso, Simona Tommasi, Anne Decor, Charles Large, Agostino Marasco
  • Modulators of KV3 channels to treat pain
    Patent number: 11147813
    Abstract: The present invention provides a modulator of Kv3.1 and/or Kv3.2 and/or Kv3.3 channels for use in the prophylaxis or treatment of pain. Modulators for use in the prophylaxis or treatment of pain include compounds of formula (I) or a pharmaceutically acceptable salt and/or solvate thereof and/or derivative thereof: (I).
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: October 19, 2021
    Assignee: Autifony Therapeutics Limited
    Inventors: Charles Large, Giuseppe Alvaro
  • HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS
    Publication number: 20200360379
    Abstract: The disclosure provides compounds of formula (I): said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Application
    Filed: August 4, 2020
    Publication date: November 19, 2020
    Inventors: Giuseppe ALVARO, Paolo DAMBRUOSO, Simona TOMMASI, Anne DECOR, Charles LARGE, Agostino MARASCO
  • IMIDAZOLIDINEDIONE DERIVATIVES
    Publication number: 20200163964
    Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.
    Type: Application
    Filed: January 30, 2020
    Publication date: May 28, 2020
    Inventors: Giuseppe ALVARO, Anne DECOR, Stefano FONTANA, Dieter HAMPRECHT, Charles LARGE, Agostino MARASCO
  • Imidazolidinedione derivatives
    Patent number: 10632118
    Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: April 28, 2020
    Assignee: AUTIFONY THERAPEUTICS LIMITED
    Inventors: Giuseppe Alvaro, Anne Decor, Stefano Fontana, Dieter Hamprecht, Charles Large, Agostino Marasco
  • HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS
    Publication number: 20190192516
    Abstract: The disclosure provides compounds of formula (I): said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Application
    Filed: February 26, 2019
    Publication date: June 27, 2019
    Inventors: Giuseppe ALVARO, Paolo DAMBRUOSO, Simona TOMMASI, Anne DECOR, Charles LARGE, Agostino MARASCO
  • Hydantoin derivatives useful as Kv3 inhibitors
    Patent number: 10265316
    Abstract: The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: April 23, 2019
    Assignee: AUTIFONY THERAPEUCTICS LIMITED
    Inventors: Giuseppe Alvaro, Paolo Dambruoso, Simona Tommasi, Anne Decor, Charles Large, Agostino Marasco
  • MODULATORS OF KV3 CHANNELS TO TREAT PAIN
    Publication number: 20190000848
    Abstract: The present invention provides a modulator of Kv3.1 and/or Kv3.2 and/or Kv3.3 channels for use in the prophylaxis or treatment of pain. Modulators for use in the prophylaxis or treatment of pain include compounds of formula (I) or a pharmaceutically acceptable salt and/or solvate thereof and/or derivative thereof: (I).
    Type: Application
    Filed: December 9, 2016
    Publication date: January 3, 2019
    Inventors: Charles LARGE, Giuseppe ALVARO
  • IMIDAZOLIDINEDIONE DERIVATIVES
    Publication number: 20180338974
    Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.
    Type: Application
    Filed: July 30, 2018
    Publication date: November 29, 2018
    Inventors: Giuseppe ALVARO, Anne Decor, Stefano fontana, Dieter Hamprecht, Charles Large, Agostino Marasco
  • Imidazolidinedione derivatives
    Patent number: 10058551
    Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: August 28, 2018
    Assignee: Autifony Therapeutics Limited
    Inventors: Giuseppe Alvaro, Anne Decor, Stefano Fontana, Dieter Hamprecht, Charles Large, Agostino Marasco
  • IMIDAZOLIDINEDIONE DERIVATIVES
    Publication number: 20180021336
    Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.
    Type: Application
    Filed: October 2, 2017
    Publication date: January 25, 2018
    Inventors: Giuseppe ALVARO, Anne DECOR, Stefano FONTANA, Dieter HAMPRECHT, Charles LARGE, Agostino MARASCO
  • Imidazolidinedione derivatives
    Patent number: 9849131
    Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: December 26, 2017
    Assignee: AUTIFONY THERAPEUTICS LIMITED
    Inventors: Giuseppe Alvaro, Anne Decor, Stefano Fontana, Dieter Hamprecht, Charles Large, Agostino Marasco
  • HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS
    Publication number: 20170273981
    Abstract: The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Application
    Filed: June 13, 2017
    Publication date: September 28, 2017
    Inventors: Giuseppe ALVARO, Paolo DAMBRUOSO, Simona TOMMASI, Anne DECOR, Charles LARGE, Agostino MARASCO
  • Hydantoin derivatives as Kv3 inhibitors
    Patent number: 9669030
    Abstract: The present invention relates to the prophylaxis of acute noise-induced hearing loss by administering a compound of formula (I): wherein: W is group (Wa), group (Wb) or group (Wc):
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: June 6, 2017
    Assignee: AUTIFONY THERAPEUTICS LIMITED
    Inventor: Charles Large
  • IMIDAZOLIDINEDIONE DERIVATIVES
    Publication number: 20170065585
    Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.
    Type: Application
    Filed: November 10, 2016
    Publication date: March 9, 2017
    Inventors: Giuseppe ALVARO, Anne DECOR, Stefano FONTANA, Dieter HAMPRECHT, Charles LARGE, Agostino MARASCO
  • HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS
    Publication number: 20160251340
    Abstract: The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
    Type: Application
    Filed: April 7, 2016
    Publication date: September 1, 2016
    Inventors: Giuseppe ALVARO, Paolo DAMBRUOSO, Simona TOMMASI, Anne DECOR, Charles LARGE, Agostino MARASCO