Abstract: An online life science research environment and virtual community with a focus on design and analysis of biological experiments includes a life sciences laboratory system employing at least one networked computer system that defines a virtual research environment. Users access the system through a portal associated with the networked computer system(s). The virtual research environment has a data coupling mechanism by which the user designates a set of user-specified data for bioinformatics processing. A processor(s) associated with the networked computer system(s) performs bioinformatics services upon the user-specified data. In one embodiment, the data coupling mechanism enables transfer of the user-specified data to a memory space that is mediated or accessed by the processor performing the bioinformatics processing.

Abstract: A client device receives a broadcast content signal containing an interactive identifier over a managed network at a client device. The interactive identifier may be a trigger that is included in a header or embedded within the digital video data. The trigger may have a temporal component, wherein the trigger can expire after a certain period of time. In response to identification of the trigger, the client device sends a user request for interactive content over an unmanaged network. For example, the managed network may be a one-way satellite television network, IP-television network or cable television network and the unmanaged network may be the Internet. The client device switches between receiving data from the managed network to receiving data from the unmanaged network.

Abstract: A computer-implemented method for creating in the encoded domain one or more video frames from a compressed still video image wherein image content in the created video frames is translated in location by panning or scrolling or a combination thereof on a non-block basis (i.e. pixel-level). A new block formed from portions of two other blocks is created by processing the original two blocks with identity matrices based upon the shift amount. By performing the creation process in the encoded domain processing power requirements are reduced and image quality is increased.

Abstract: A system and method for calculating data representative of at least one intermediary transition image between a first image and a second image in the encoded domain is disclosed. Cinematic transitions can be created between encoded still images and frames from video sequences. For each corresponding location within the first and second image, a transform coded value is calculated for the at least one intermediary image using the transform encoded data of the first and second images without transform decoding the transform encoded data. The transform coded values can be fully encoded using a compression protocol and transmitted to a device for decoding and display of the cinematic transition.

Abstract: A client device receives a broadcast content signal containing an interactive identifier over a managed network at a client device. The interactive identifier may be a trigger that is included in a header or embedded within the digital video data. The trigger may have a temporal component, wherein the trigger can expire after a certain period of time. In response to identification of the trigger, the client device sends a user request for interactive content over an unmanaged network. For example, the managed network may be a one-way satellite television network, IP-television network or cable television network and the unmanaged network may be the Internet. The client device switches between receiving data from the managed network to receiving data from the unmanaged network.

Abstract: A computer-implemented method for creating in the encoded domain one or more video frames from a compressed still video image wherein image content in the created video frames is translated in location by panning or scrolling or a combination thereof on a non-block basis (i.e. pixel-level). A new block formed from portions of two other blocks is created by processing the original two blocks with identity matrices based upon the shift amount. By performing the creation process in the encoded domain processing power requirements are reduced and image quality is increased.

Abstract: A client device receives a broadcast content signal containing an interactive identifier over a managed network at a client device. The interactive identifier may be a trigger that is included in a header or embedded within the digital video data. The trigger may have a temporal component, wherein the trigger can expire after a certain period of time. In response to identification of the trigger, the client device sends a user request for interactive content over an unmanaged network. For example, the managed network may be a one-way satellite television network, IP-television network or cable television network and the unmanaged network may be the Internet. The client device switches between receiving data from the managed network to receiving data from the unmanaged network.

Abstract: A system and method for calculating data representative of at least one intermediary transition image between a first image and a second image in the encoded domain is disclosed. Cinematic transitions can be created between encoded still images and frames from video sequences. For each corresponding location within the first and second image, a transform coded value is calculated for the at least one intermediary image using the transform encoded data of the first and second images without transform decoding the transform encoded data. The transform coded values can be fully encoded using a compression protocol and transmitted to a device for decoding and display of the cinematic transition.

Abstract: Disclosed herein are carbonyl compounds of Formula: (I) as described herein. Compounds as modulators of his-tone deacetylase (HDAC), pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.

Abstract: A method of forming a particle mass comprising at least two particle populations arranged in a desired graded relationship, comprising: forming in a container a first layer of dry particles constituting a first particle population having a desired particle size distribution, superimposing on the first layer a second layer of dry particles constituting a second particle population having a desired particle size distribution, the second layer being in direct contact with the first layer at a contact interface, and causing the particle mass in the container to vibrate to cause a desired degree of migration of particles from one or both layers across the contact interface under the influence of force experienced by particles in the mass. The particle populations may have different physical and/or chemical properties, so that the particle mass is functionally graded for subsequent fusion into a functionally graded material such as a ceramic or ceramic/metal composite.

Abstract: Disclosed herein are carbonyl compounds of Formula I as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.

Abstract: Disclosed herein are carbonyl compounds of having the structural formula: or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.

Abstract: An online life science research environment and virtual community with a focus on design and analysis of biological experiments includes a life sciences laboratory system employing at least one networked computer system that defines a virtual research environment. Users access the system through a portal associated with the networked computer system(s). The virtual research environment has a data coupling mechanism by which the user designates a set of user-specified data for bioinformatics processing. A processor(s) associated with the networked computer system(s) performs bioinformatics services upon the user-specified data. In one embodiment, the data coupling mechanism enables transfer of the user-specified data to a memory space that is mediated or accessed by the processor performing the bioinformatics processing.

Abstract: A transceiver for a LAN is capable of communicating multiple bits per signal element to increase the data throughput of the LAN. The transceiver includes a transmitter which receives a multiple bit digital input value originating at a node of the LAN at which the transceiver is present. The transmitter converts the multiple bit digital input signal into a pulse-like analog signal which is amplitude and phase modulated. A receiver of a transceiver at a receiving node the transmitted analog signal converts its amplitude and phase into a corresponding multiple bit digital output value. A time-domain filter of the receiver creates a primary signal from the received analog signal. To sample the primary signal at its maximum amplitude point, a derivative of the primary signal waveform is used to establish the zero derivative point at which the primary signal attains its maximum amplitude, and to establish a fixed sampling point for subsequent signals.