Patents by Inventor Charles Lee Hershberger

Charles Lee Hershberger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ketoreductase gene and protein from yeast
    Patent number: 6531308
    Abstract: The invention provides cloned ketoreductase genes, vectors for expressing same, recombinant host cells that express said vector-borne genes, a method for stereospecifically reducing a ketone using a recombinant ketoreductase, or a recombinant host cell that expresses a cloned ketoreductase gene, as well as a method for generating polynucleotide sequences more conducive to recombinant expression.
    Type: Grant
    Filed: October 8, 1999
    Date of Patent: March 11, 2003
    Assignee: Eli Lilly and Company
    Inventors: Charles Lee Hershberger, Robert Allen Payson
  • KETOREDUCTASE GENE AND PROTEIN FROM YEAST
    Publication number: 20020045233
    Abstract: The invention provides cloned ketoreductase genes, vectors for expressing same, recombinant host cells that express said vector-borne genes, a method for stereospecifically reducing a ketone using a recombinant ketoreductase, or a recombinant host cell that expresses a cloned ketoreductase gene, as well as a method for generating polynucleotide sequences more conducive to recombinant expression.
    Type: Application
    Filed: October 8, 1999
    Publication date: April 18, 2002
    Inventors: CHARLES LEE HERSHBERGER, ROBERT ALLEN PAYSON
  • Methods of reducing the levels of protoporphyrin IX in recombinant hemoglobin preparations
    Patent number: 6136565
    Abstract: The present invention relates to recombinant hemoglobin solutions containing reduced amounts of protoporphyrin IX and to methods of producing such hemoglobin solutions. The methods are accomplished by overexpressing the hemH gene in a suitable host cell or by increasing the production of hemH in a host cell, for example, by integration of the hemH gene into the chromosome of the host cell or by inserting multiple copies of the gene in host cells naturally having a hemH gene.
    Type: Grant
    Filed: October 18, 1999
    Date of Patent: October 24, 2000
    Assignees: Baxter Biotech Technology Sarl, Eli Lilly and Company
    Inventors: Elaine A. Best, Charles Lee Hershberger, Christopher Carl Frye
  • Bovine dipeptidylaminopeptidase 1
    Patent number: 6027911
    Abstract: The present invention provides the cDNA sequence encoding bovine dipeptidylaminopeptidase 1. The invention demonstrates that bovine DAP 1 coded by a single cDNA. The mature protein is derived from a single polypeptide consisting of a signal peptide, and a major polypeptide which is processed to generate the a subunit, b subunit and g subunit.
    Type: Grant
    Filed: April 3, 1998
    Date of Patent: February 22, 2000
    Assignee: Eli Lilly and Company
    Inventors: Christopher Carl Frye, Charles Lee Hershberger, Haichao Zhang
  • Bovine dipeptidylaminopeptidase 1
    Patent number: 6008041
    Abstract: The present invention provides the cDNA sequence encoding bovine dipeptidylaminopeptidase 1. The invention demonstrates that bovine DAP 1 coded by a single cDNA. The mature protein is derived from a single polypeptide consisting of a signal peptide, and a major polypeptide which is processed to generate the a subunit, b subunit and g subunit.
    Type: Grant
    Filed: May 2, 1997
    Date of Patent: December 28, 1999
    Assignee: Eli Lilly and Company
    Inventors: Christopher Carl Frye, Charles Lee Hershberger, Haichao Zhang