Patents by Inventor Charles Lemelin

Charles Lemelin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for preparing immunological adjuvant
    Patent number: 8962857
    Abstract: The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: February 24, 2015
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Francis G. Fang, James E. Foy, Lynn Hawkins, Charles Lemelin, Andre LesCarbeau, Xiang Niu, Kuo-Ming Wu
  • COMPOUNDS FOR PREPARING IMMUNOLOGICAL ADJUVANT
    Publication number: 20140323739
    Abstract: The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates.
    Type: Application
    Filed: May 5, 2014
    Publication date: October 30, 2014
    Applicant: Eisai R&D Management Co.. Ltd.
    Inventors: Francis G. Fang, James E. Foy, Lynn Hawkins, Charles Lemelin, Andre LesCarbeau, Xiang Niu, Kuo-Ming Wu
  • Compounds for preparing immunological adjuvant
    Patent number: 8754236
    Abstract: The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates.
    Type: Grant
    Filed: July 22, 2013
    Date of Patent: June 17, 2014
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Francis G. Fang, James E. Foy, Lynn Hawkins, Charles Lemelin, Andre LesCarbeau, Xiang Niu, Kuo-Ming Wu
  • COMPOUNDS FOR PREPARING IMMUNOLOGICAL ADJUVANT
    Publication number: 20140012011
    Abstract: The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates.
    Type: Application
    Filed: July 22, 2013
    Publication date: January 9, 2014
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Francis G. Fang, James E. Foy, Lynn Hawkins, Charles Lemelin, Andre LesCarbeau, Xiang Niu, Kuo-Ming Wu
  • Compounds for preparing immunological adjuvant
    Patent number: 8519170
    Abstract: The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: August 27, 2013
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Francis G. Fang, James E. Foy, Lynn Hawkins, Charles Lemelin, Andre Lescarbeau, Xiang Niu, Kuo-Ming Wu
  • COMPOUNDS FOR PREPARING IMMUNOLOGICAL ADJUVANT
    Publication number: 20120232298
    Abstract: The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates.
    Type: Application
    Filed: May 10, 2012
    Publication date: September 13, 2012
    Inventors: Francis G. Fang, James E. Foy, Lynn Hawkins, Charles Lemelin, Andre Lescarbeau, Xiang Niu, Kuo-Ming Wu
  • Compounds for preparing immunological adjuvant
    Patent number: 8198474
    Abstract: The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates useful for implementing the inventive methods.
    Type: Grant
    Filed: February 2, 2010
    Date of Patent: June 12, 2012
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Francis G. Fang, James E. Foy, Lynn Hawkins, Charles Lemelin, Andre Lescarbeau, Xiang Niu, Kuo-Ming Wu
  • Reagents and methods for the beta-keto amide synthesis of a synthetic precursor to immunological adjuvant E6020
    Patent number: 8049023
    Abstract: This invention relates to the synthesis for a precursor of E6020, compound 26, via a ?-keto amide alcohol intermediate, compound 22. The synthesis reacts compound 22 with compound 25 and the resultant intermediate is oxidized to produce compound 26, the precursor to E6020. Compounds 22 and 25, and their crystalline forms, represent separate embodiments of the invention. The invention also relates to compounds of formulas (3) and (4) and processes for their preparation. The ?-keto amide alcohol intermediate compound 22 is a compound of formula (3). Compound 25 is a compound of formula (4).
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: November 1, 2011
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Bruce DeCosta, Francis G. Fang, James E. Foy, Lynn Hawkins, Charles Lemelin, Xiang Niu, Kuo-Ming Wu
  • Reagents and methods for the beta-keto amide synthesis of a synthetic precursor to immunological adjuvant E6020
    Patent number: 7919643
    Abstract: This invention relates to the synthesis for a precursor of E6020, compound 26, via a ?-keto amide alcohol intermediate, compound 22. The synthesis reacts compound 22 with compound 25 and the resultant intermediate is oxidized to produce compound 26, the precursor to E6020. Compounds 22 and 25, and their crystalline forms, represent separate embodiments of the invention. The invention also relates to compounds of formulas (3) and (4) and processes for their preparation. The ?-keto amide alcohol intermediate compound 22 is a compound of formula (3). Compound 25 is a compound of formula (4).
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: April 5, 2011
    Assignee: Eisai R & D Management Co., Ltd.
    Inventors: Bruce DeCosta, Francis G. Fang, James E. Foy, Lynn Hawkins, Charles Lemelin, Xiang Niu, Kuo-Ming Wu
  • REAGENTS AND METHODS FOR THE BETA-KETO AMIDE SYNTHESIS OF A SYNTHETIC PRECURSOR TO IMMUNOLOGICAL ADJUVANT E6020
    Publication number: 20110060151
    Abstract: This invention relates to the synthesis for a precursor of E6020, compound 26, via a ?-keto amide alcohol intermediate, compound 22. The synthesis reacts compound 22 with compound 25 and the resultant intermediate is oxidized to produce compound 26, the precursor to E6020. Compounds 22 and 25, and their crystalline forms, represent separate embodiments of the invention. The invention also relates to compounds of formulas (3) and (4) and processes for their preparation. The ?-keto amide alcohol intermediate compound 22 is a compound of formula (3). Compound 25 is a compound of formula (4).
    Type: Application
    Filed: November 15, 2010
    Publication date: March 10, 2011
    Applicant: EISAI R & D MANAGEMENT CO., LTD.
    Inventors: Bruce DECOSTA, Francis G. FANG, James E. FOY, Lynn HAWKINS, Charles LEMELIN, Xiang NIU, Kuo-Ming WU
  • COMPOUNDS FOR PREPARING IMMUNOLOGICAL ADJUVANT
    Publication number: 20100197951
    Abstract: The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates useful for implementing the inventive methods.
    Type: Application
    Filed: February 2, 2010
    Publication date: August 5, 2010
    Applicant: Eisai R & D Management Co., Ltd.
    Inventors: Francis G. FANG, James E. Foy, Lynn Hawkins, Charles Lemelin, Andre Lescarbeau, Xiang Nu, Kuo-Ming Wu
  • Compounds for preparing immunological adjuvant
    Patent number: 7683200
    Abstract: The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates.
    Type: Grant
    Filed: June 30, 2006
    Date of Patent: March 23, 2010
    Assignee: Eisai R & D Management Co., Ltd.
    Inventors: Francis G. Fang, James E. Foy, Lynn Hawkins, Charles Lemelin, Andre Lescarbeau, Xiang Nu, Kuo-Ming Wu
  • REAGENTS AND METHODS FOR THE BETA-KETO AMIDE SYNTHESIS OF A SYNTHETIC PRECURSOR TO IMMUNOLOGICAL ADJUVANT E6020
    Publication number: 20090187038
    Abstract: This invention relates to the synthesis for a precursor of E6020, compound 26, via a ?-keto amide alcohol intermediate, compound 22. The synthesis reacts compound 22 with compound 25 and the resultant intermediate is oxidized to produce compound 26, the precursor to E6020. Compounds 22 and 25, and their crystalline forms, represent separate embodiments of the invention. The invention also relates to compounds of formulas (3) and (4) and processes for their preparation. The ?-keto amide alcohol intermediate compound 22 is a compound of formula (3). Compound 25 is a compound of formula (4).
    Type: Application
    Filed: December 18, 2008
    Publication date: July 23, 2009
    Inventors: Bruce DeCosta, Francis G. Fang, James E. Foy, Lynn Hawkins, Charles Lemelin, Xiang Niu, Kuo-Ming Wu
  • Compounds for preparing immunological adjuvant
    Publication number: 20070082875
    Abstract: The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates.
    Type: Application
    Filed: June 30, 2006
    Publication date: April 12, 2007
    Applicant: Eisai Co., Ltd.
    Inventors: Francis Fang, James Foy, Lynn Hawkins, Charles Lemelin, Andre Lescarbeau, Xiang Niu, Kuo-Ming Wu